Orchestrating mitochondria in neurons: Cytoskeleton as the conductor

Detalhes bibliográficos
Autor(a) principal: Cardanho-Ramos, Carlos
Data de Publicação: 2020
Outros Autores: Faria-Pereira, Andreia, Morais, Vanessa A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49563
Resumo: © 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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spelling Orchestrating mitochondria in neurons: Cytoskeleton as the conductorDockingMitochondriaNeuronal cytoskeletonSynapseTransport© 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca2+ homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub-compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post-mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.The authors are supported by Fundação para a Ciência e Tecnologia, Grant references for CCRPD/BD/135521/2018, AFP PD/BD/114113/2015, VAM IF/01693/2014, Funding reference: UID/BIM/50005/2019, project funded by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado; by European Research Council, grant ERC-StG-679168; and European Molecular Biology Organization, grant EMBO-IG/3309.John Wiley & Sons, Inc.Repositório da Universidade de LisboaCardanho-Ramos, CarlosFaria-Pereira, AndreiaMorais, Vanessa A.2021-09-21T15:29:14Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49563engCytoskeleton (Hoboken). 2020 Mar;77(3-4):65-751949-358410.1002/cm.215851949-3592info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:27Zoai:repositorio.ul.pt:10451/49563Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:11.579805Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
title Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
spellingShingle Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
Cardanho-Ramos, Carlos
Docking
Mitochondria
Neuronal cytoskeleton
Synapse
Transport
title_short Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
title_full Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
title_fullStr Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
title_full_unstemmed Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
title_sort Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
author Cardanho-Ramos, Carlos
author_facet Cardanho-Ramos, Carlos
Faria-Pereira, Andreia
Morais, Vanessa A.
author_role author
author2 Faria-Pereira, Andreia
Morais, Vanessa A.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cardanho-Ramos, Carlos
Faria-Pereira, Andreia
Morais, Vanessa A.
dc.subject.por.fl_str_mv Docking
Mitochondria
Neuronal cytoskeleton
Synapse
Transport
topic Docking
Mitochondria
Neuronal cytoskeleton
Synapse
Transport
description © 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-09-21T15:29:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49563
url http://hdl.handle.net/10451/49563
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cytoskeleton (Hoboken). 2020 Mar;77(3-4):65-75
1949-3584
10.1002/cm.21585
1949-3592
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons, Inc.
publisher.none.fl_str_mv John Wiley & Sons, Inc.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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