A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Raquel O.
Data de Publicação: 2018
Outros Autores: Baldi, Giovanni, Doumett, Saer, Gallo, Juan, Bañobre-López, Manuel, Dražić, Goran, Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Lima, Rui Alberto Madeira Macedo, Silva, Adrián M. T., Gomes, Helder T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/60016
Resumo: A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.
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spelling A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicinegraphene magnetic nanocompositesdrug deliveryDOX cancerScience & TechnologyA simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.This research was funded by Project POCI-01-0145-FEDER-006984 - Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) - and by national funds through FCT - Fundação para a Ciência e a Tecnologia, and by project NORTE-01-0145-FEDER-029394, RTChip4Theranostics, supported by Programa Operacional Regional do Norte - Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by Fundação para a Ciência e Tecnologia (FCT), IP.R.O.R. acknowledges the Ph.D. scholarship SFRH/BD/97658/2013 granted by FCT. G.D. acknowledges financing by Slovene Research Agency (J2-6754). The authors also would like to acknowledge the financial support provided by COST—European Cooperation in Science and Technology, in the form of a short term scientific mission (STSM) granted by COST Action TD1402: RADIOMAG.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing InstituteUniversidade do MinhoRodrigues, Raquel O.Baldi, GiovanniDoumett, SaerGallo, JuanBañobre-López, ManuelDražić, GoranCalhelha, Ricardo C.Ferreira, Isabel C. F. R.Lima, Rui Alberto Madeira MacedoSilva, Adrián M. T.Gomes, Helder T.2018-10-132018-10-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/60016eng2311-562910.3390/c4040055info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:50Zoai:repositorium.sdum.uminho.pt:1822/60016Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:19.994054Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
title A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
spellingShingle A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
Rodrigues, Raquel O.
graphene magnetic nanocomposites
drug delivery
DOX cancer
Science & Technology
title_short A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
title_full A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
title_fullStr A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
title_full_unstemmed A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
title_sort A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
author Rodrigues, Raquel O.
author_facet Rodrigues, Raquel O.
Baldi, Giovanni
Doumett, Saer
Gallo, Juan
Bañobre-López, Manuel
Dražić, Goran
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Lima, Rui Alberto Madeira Macedo
Silva, Adrián M. T.
Gomes, Helder T.
author_role author
author2 Baldi, Giovanni
Doumett, Saer
Gallo, Juan
Bañobre-López, Manuel
Dražić, Goran
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Lima, Rui Alberto Madeira Macedo
Silva, Adrián M. T.
Gomes, Helder T.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Raquel O.
Baldi, Giovanni
Doumett, Saer
Gallo, Juan
Bañobre-López, Manuel
Dražić, Goran
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Lima, Rui Alberto Madeira Macedo
Silva, Adrián M. T.
Gomes, Helder T.
dc.subject.por.fl_str_mv graphene magnetic nanocomposites
drug delivery
DOX cancer
Science & Technology
topic graphene magnetic nanocomposites
drug delivery
DOX cancer
Science & Technology
description A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-13
2018-10-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/60016
url http://hdl.handle.net/1822/60016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2311-5629
10.3390/c4040055
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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