A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/60016 |
Resumo: | A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer. |
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A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicinegraphene magnetic nanocompositesdrug deliveryDOX cancerScience & TechnologyA simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.This research was funded by Project POCI-01-0145-FEDER-006984 - Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) - and by national funds through FCT - Fundação para a Ciência e a Tecnologia, and by project NORTE-01-0145-FEDER-029394, RTChip4Theranostics, supported by Programa Operacional Regional do Norte - Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by Fundação para a Ciência e Tecnologia (FCT), IP.R.O.R. acknowledges the Ph.D. scholarship SFRH/BD/97658/2013 granted by FCT. G.D. acknowledges financing by Slovene Research Agency (J2-6754). The authors also would like to acknowledge the financial support provided by COST—European Cooperation in Science and Technology, in the form of a short term scientific mission (STSM) granted by COST Action TD1402: RADIOMAG.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing InstituteUniversidade do MinhoRodrigues, Raquel O.Baldi, GiovanniDoumett, SaerGallo, JuanBañobre-López, ManuelDražić, GoranCalhelha, Ricardo C.Ferreira, Isabel C. F. R.Lima, Rui Alberto Madeira MacedoSilva, Adrián M. T.Gomes, Helder T.2018-10-132018-10-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/60016eng2311-562910.3390/c4040055info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:50Zoai:repositorium.sdum.uminho.pt:1822/60016Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:19.994054Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
title |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
spellingShingle |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine Rodrigues, Raquel O. graphene magnetic nanocomposites drug delivery DOX cancer Science & Technology |
title_short |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
title_full |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
title_fullStr |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
title_full_unstemmed |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
title_sort |
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanoparticles for nanomedicine |
author |
Rodrigues, Raquel O. |
author_facet |
Rodrigues, Raquel O. Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C. F. R. Lima, Rui Alberto Madeira Macedo Silva, Adrián M. T. Gomes, Helder T. |
author_role |
author |
author2 |
Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C. F. R. Lima, Rui Alberto Madeira Macedo Silva, Adrián M. T. Gomes, Helder T. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rodrigues, Raquel O. Baldi, Giovanni Doumett, Saer Gallo, Juan Bañobre-López, Manuel Dražić, Goran Calhelha, Ricardo C. Ferreira, Isabel C. F. R. Lima, Rui Alberto Madeira Macedo Silva, Adrián M. T. Gomes, Helder T. |
dc.subject.por.fl_str_mv |
graphene magnetic nanocomposites drug delivery DOX cancer Science & Technology |
topic |
graphene magnetic nanocomposites drug delivery DOX cancer Science & Technology |
description |
A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-13 2018-10-13T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/60016 |
url |
http://hdl.handle.net/1822/60016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2311-5629 10.3390/c4040055 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132679703101440 |