Do we have a channel solution for ALS?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/53428 |
Resumo: | © 2015 The Author. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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Do we have a channel solution for ALS?© 2015 The Author. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Amyotrophic lateral sclerosis (ALS) is a dreadful degenerative disorder, characterized by rapidly progressing weakness causing respiratory impairment and death, in spite of moderate benefits from non-invasive ventilation, gastrostomy, riluzole treatment and multidisciplinary care (Andersen et al., 2012). Over the years a large of number of drugs have been tested to deal with this disorder, but all trials have been negative except for riluzole. We can observe that different strategies have been explored in the past, from immunosuppression to neuroprotection, from nerve growth factors to antiglutamatergic compounds (de Carvalho et al., 2005). Threshold tracking has been used to investigate axonal excitability in peripheral nerve motor axons in ALS (Vucic and Kiernan, 2006). Increased persistent Na+ conductance and reduced K+ conductance have been described (Vucic and Kiernan, 2006), which tend to become more marked with disease duration and may be a predictor of survival (Cheah et al., 2012). More recently, it has been suggested that motor neurons have an abnormal function of the membrane ion channels, in ALS (Devlin et al., 2015). These observations have opened a new window of opportunity in clinical trials for ALS, for testing drugs that modulate ion channels in order to stabilize membranes.ElsevierRepositório da Universidade de LisboaCarvalho, Mamede2022-06-21T15:35:29Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53428engEBioMedicine. 2015 Dec 3;2(12):1842-184310.1016/j.ebiom.2015.12.0022352-3964info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:59:11Zoai:repositorio.ul.pt:10451/53428Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:22.630475Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Do we have a channel solution for ALS? |
| title |
Do we have a channel solution for ALS? |
| spellingShingle |
Do we have a channel solution for ALS? Carvalho, Mamede |
| title_short |
Do we have a channel solution for ALS? |
| title_full |
Do we have a channel solution for ALS? |
| title_fullStr |
Do we have a channel solution for ALS? |
| title_full_unstemmed |
Do we have a channel solution for ALS? |
| title_sort |
Do we have a channel solution for ALS? |
| author |
Carvalho, Mamede |
| author_facet |
Carvalho, Mamede |
| author_role |
author |
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Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Carvalho, Mamede |
| description |
© 2015 The Author. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| publishDate |
2015 |
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2015 2015-01-01T00:00:00Z 2022-06-21T15:35:29Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/53428 |
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http://hdl.handle.net/10451/53428 |
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eng |
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eng |
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EBioMedicine. 2015 Dec 3;2(12):1842-1843 10.1016/j.ebiom.2015.12.002 2352-3964 |
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openAccess |
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Elsevier |
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Elsevier |
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