The role of muscle in the susceptibility and progression of axial Spondyloarthritis
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/142590 |
Resumo: | declArAtions ETHICS APPROVAL AND CONSENT TO PARTICIPATE The current study was submitted and approved by the ethical committee of University of Lisbon and Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, EPE (Reference Number: 20170700050). The study will be conducted in accordance with the International Conference on Harmonization Good Clinical Practice (GCP) and the Declaration of Helsinki. Furthermore, voluntary written informed participants’ consent will be obtained from all subjects before the start of the study procedures. FUNDING This study was supported by iNOVA4Health (consortia to create a multidisdiplinary/translational network at the NOVA University, Lisbon, Portugal) and Portuguese Society of Rheumatology grants. |
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The role of muscle in the susceptibility and progression of axial SpondyloarthritisThe MyoSpA Study ProtocolAdolescentAdultAnimalsAxial SpondyloarthritisCross-Sectional StudiesHumansMiceMiddle AgedMusclesSpondylarthritisSpondylitis, AnkylosingYoung AdultBiochemistry, Genetics and Molecular Biology(all)Medicine(all)SDG 3 - Good Health and Well-beingdeclArAtions ETHICS APPROVAL AND CONSENT TO PARTICIPATE The current study was submitted and approved by the ethical committee of University of Lisbon and Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, EPE (Reference Number: 20170700050). The study will be conducted in accordance with the International Conference on Harmonization Good Clinical Practice (GCP) and the Declaration of Helsinki. Furthermore, voluntary written informed participants’ consent will be obtained from all subjects before the start of the study procedures. FUNDING This study was supported by iNOVA4Health (consortia to create a multidisdiplinary/translational network at the NOVA University, Lisbon, Portugal) and Portuguese Society of Rheumatology grants.BACKGROUND: Axial Spondyloarthritis (axSpA) is a chronic, inflammatory rheumatic disease that affects the axial skeleton, causing pain, stiffness, and fatigue. Genetics and environmental factors such as microbiota and microtrauma are known causes of disease susceptibility and progression. Murine models of axSpA found a decisive role for biomechanical stress as an inducer of enthesitis and new bone formation. Here, we hypothesize that muscle properties in axSpA patients are compromised and influenced by genetic background. OBJECTIVES: To improve our current knowledge of axSpA physiopathology, we aim to characterize axial and peripheral muscle properties and identify genetic and protein biomarker that might explain such properties. METHODS: A cross-sectional study will be conducted on 48 participants aged 18-50 years old, involving patients with axSpA (according to ASAS classification criteria, symptoms duration < 10 years) and healthy controls matched by gender, age, and levels of physical activity. We will collect epidemiological and clinical data and perform a detailed, whole body and segmental, myofascial characterization (focusing on multifidus, brachioradialis and the gastrocnemius lateralis) concerning: a) Physical Properties (stiffness, tone and elasticity), assessed by MyotonPRO®; b) Strength, by a dynamometer; c) Mass, by bioimpedance; d) Performance through gait speed and 60-second sit-to-stand test; e) Histological and cellular/ molecular characterization through ultrasound-guided biopsies of multifidus muscle; f) Magnetic Resonance Imaging (MRI) characterization of paravertebral muscles. Furthermore, we will perform an integrated transcriptomics and proteomics analysis of peripheral blood samples. DISCUSSION: The innovative and multidisciplinary approaches of this project rely on the elucidation of myofascial physical properties in axSpA and also on the establishment of a biological signature that relates to specific muscle properties. This hitherto unstudied link between gene/protein signatures and muscle properties may enhance our understanding of axSpA physiopathology and reveal new and useful diagnostic and therapeutic targets.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Instituto de Higiene e Medicina Tropical (IHMT)Instituto de Tecnologia Química e Biológica António Xavier (ITQB)Global Health and Tropical Medicine (GHTM)TB, HIV and opportunistic diseases and pathogens (THOP)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaCEFAGE (Pólo FCT/NOVA) - Centro de Estudos e Formação Avançada em Gestão e EconomiaRUNSardoo, Atlas MashayekhiNeto, AgnaPinheiro Torres, RitaRodrigues-Manica, SantiagoDomingues, LúciaLage Crespo, CarolinaLagoas-Gomes, JoãoMascarenhas, VascoMendes, César SGalzerano, AntonioFernandes de Almeida, SérgioSepriano, AlexandreRamiro, SofiaMasi, Alfonse TNair, KalyaniCosta, JuliaAlexandre, Bruno MiguelVassilevskaia, TatianaCunha, Celso VladimiroSobral, DanielBranco, Jaime CunhaGomes-Alves, PatríciaPimentel-Santos, Fernando M2022-07-28T22:22:32Z2021-12-292021-12-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/142590eng0303-464XPURE: 36375569info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:20:22Zoai:run.unl.pt:10362/142590Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:24.469293Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis The MyoSpA Study Protocol |
| title |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis |
| spellingShingle |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis Sardoo, Atlas Mashayekhi Adolescent Adult Animals Axial Spondyloarthritis Cross-Sectional Studies Humans Mice Middle Aged Muscles Spondylarthritis Spondylitis, Ankylosing Young Adult Biochemistry, Genetics and Molecular Biology(all) Medicine(all) SDG 3 - Good Health and Well-being |
| title_short |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis |
| title_full |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis |
| title_fullStr |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis |
| title_full_unstemmed |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis |
| title_sort |
The role of muscle in the susceptibility and progression of axial Spondyloarthritis |
| author |
Sardoo, Atlas Mashayekhi |
| author_facet |
Sardoo, Atlas Mashayekhi Neto, Agna Pinheiro Torres, Rita Rodrigues-Manica, Santiago Domingues, Lúcia Lage Crespo, Carolina Lagoas-Gomes, João Mascarenhas, Vasco Mendes, César S Galzerano, Antonio Fernandes de Almeida, Sérgio Sepriano, Alexandre Ramiro, Sofia Masi, Alfonse T Nair, Kalyani Costa, Julia Alexandre, Bruno Miguel Vassilevskaia, Tatiana Cunha, Celso Vladimiro Sobral, Daniel Branco, Jaime Cunha Gomes-Alves, Patrícia Pimentel-Santos, Fernando M |
| author_role |
author |
| author2 |
Neto, Agna Pinheiro Torres, Rita Rodrigues-Manica, Santiago Domingues, Lúcia Lage Crespo, Carolina Lagoas-Gomes, João Mascarenhas, Vasco Mendes, César S Galzerano, Antonio Fernandes de Almeida, Sérgio Sepriano, Alexandre Ramiro, Sofia Masi, Alfonse T Nair, Kalyani Costa, Julia Alexandre, Bruno Miguel Vassilevskaia, Tatiana Cunha, Celso Vladimiro Sobral, Daniel Branco, Jaime Cunha Gomes-Alves, Patrícia Pimentel-Santos, Fernando M |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Instituto de Higiene e Medicina Tropical (IHMT) Instituto de Tecnologia Química e Biológica António Xavier (ITQB) Global Health and Tropical Medicine (GHTM) TB, HIV and opportunistic diseases and pathogens (THOP) UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida CEFAGE (Pólo FCT/NOVA) - Centro de Estudos e Formação Avançada em Gestão e Economia RUN |
| dc.contributor.author.fl_str_mv |
Sardoo, Atlas Mashayekhi Neto, Agna Pinheiro Torres, Rita Rodrigues-Manica, Santiago Domingues, Lúcia Lage Crespo, Carolina Lagoas-Gomes, João Mascarenhas, Vasco Mendes, César S Galzerano, Antonio Fernandes de Almeida, Sérgio Sepriano, Alexandre Ramiro, Sofia Masi, Alfonse T Nair, Kalyani Costa, Julia Alexandre, Bruno Miguel Vassilevskaia, Tatiana Cunha, Celso Vladimiro Sobral, Daniel Branco, Jaime Cunha Gomes-Alves, Patrícia Pimentel-Santos, Fernando M |
| dc.subject.por.fl_str_mv |
Adolescent Adult Animals Axial Spondyloarthritis Cross-Sectional Studies Humans Mice Middle Aged Muscles Spondylarthritis Spondylitis, Ankylosing Young Adult Biochemistry, Genetics and Molecular Biology(all) Medicine(all) SDG 3 - Good Health and Well-being |
| topic |
Adolescent Adult Animals Axial Spondyloarthritis Cross-Sectional Studies Humans Mice Middle Aged Muscles Spondylarthritis Spondylitis, Ankylosing Young Adult Biochemistry, Genetics and Molecular Biology(all) Medicine(all) SDG 3 - Good Health and Well-being |
| description |
declArAtions ETHICS APPROVAL AND CONSENT TO PARTICIPATE The current study was submitted and approved by the ethical committee of University of Lisbon and Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, EPE (Reference Number: 20170700050). The study will be conducted in accordance with the International Conference on Harmonization Good Clinical Practice (GCP) and the Declaration of Helsinki. Furthermore, voluntary written informed participants’ consent will be obtained from all subjects before the start of the study procedures. FUNDING This study was supported by iNOVA4Health (consortia to create a multidisdiplinary/translational network at the NOVA University, Lisbon, Portugal) and Portuguese Society of Rheumatology grants. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-12-29 2021-12-29T00:00:00Z 2022-07-28T22:22:32Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/142590 |
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http://hdl.handle.net/10362/142590 |
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eng |
| language |
eng |
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0303-464X PURE: 36375569 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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8 application/pdf |
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