A new piezoelectric actuator induces bone formation in vivo: a preliminary study
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/7008 https://doi.org/10.1155/2012/613403 |
Resumo: | This in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, throughMasson’s trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase. After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls. Bone deposition rate was also significantly higher in the mechanically stimulated areas. In these areas, osteopontin increased expression was observed. The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth. |
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A new piezoelectric actuator induces bone formation in vivo: a preliminary studyBoneosteoblastsPiezoelectric ActuatorsheepThis in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, throughMasson’s trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase. After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls. Bone deposition rate was also significantly higher in the mechanically stimulated areas. In these areas, osteopontin increased expression was observed. The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.Hindawi Publishing Corporation2013-01-03T11:57:15Z2013-01-032012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/7008http://hdl.handle.net/10174/7008https://doi.org/10.1155/2012/613403engReis J, Frias C, Canto e Castro C, Botelho ML, Marques AT, Simões JA, Capela e Silva F, Potes J. A new piezoelectric actuator induces bone formation in vivo: a preliminary study. Journal of Biomedicine and Biotechnology 2012; Article ID 613403, doi:10.1155/2012/6134037Volume 2012Journal of Biomedicine and BiotechnologyICAAM, MVTjmfcr@uevora.ptndndndndndfcs@uevora.ptjacpotes@uevora.pt232Reis, JFrias, CCanto e Castro, CBotelho, MLMarques, ATSimões JA, JACapela e Silva, FPotes, Jinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:46:51Zoai:dspace.uevora.pt:10174/7008Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:01:38.897420Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
title |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
spellingShingle |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study Reis, J Bone osteoblasts Piezoelectric Actuator sheep |
title_short |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
title_full |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
title_fullStr |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
title_full_unstemmed |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
title_sort |
A new piezoelectric actuator induces bone formation in vivo: a preliminary study |
author |
Reis, J |
author_facet |
Reis, J Frias, C Canto e Castro, C Botelho, ML Marques, AT Simões JA, JA Capela e Silva, F Potes, J |
author_role |
author |
author2 |
Frias, C Canto e Castro, C Botelho, ML Marques, AT Simões JA, JA Capela e Silva, F Potes, J |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Reis, J Frias, C Canto e Castro, C Botelho, ML Marques, AT Simões JA, JA Capela e Silva, F Potes, J |
dc.subject.por.fl_str_mv |
Bone osteoblasts Piezoelectric Actuator sheep |
topic |
Bone osteoblasts Piezoelectric Actuator sheep |
description |
This in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, throughMasson’s trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase. After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls. Bone deposition rate was also significantly higher in the mechanically stimulated areas. In these areas, osteopontin increased expression was observed. The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01T00:00:00Z 2013-01-03T11:57:15Z 2013-01-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/7008 http://hdl.handle.net/10174/7008 https://doi.org/10.1155/2012/613403 |
url |
http://hdl.handle.net/10174/7008 https://doi.org/10.1155/2012/613403 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reis J, Frias C, Canto e Castro C, Botelho ML, Marques AT, Simões JA, Capela e Silva F, Potes J. A new piezoelectric actuator induces bone formation in vivo: a preliminary study. Journal of Biomedicine and Biotechnology 2012; Article ID 613403, doi:10.1155/2012/613403 7 Volume 2012 Journal of Biomedicine and Biotechnology ICAAM, MVT jmfcr@uevora.pt nd nd nd nd nd fcs@uevora.pt jacpotes@uevora.pt 232 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136499862601728 |