Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/86409 |
Resumo: | NCBI Accession numbers: Proteus phage BigMira-UFV01: OQ729741; Proteus phage MidiMira-UFV02; OQ729742; P. mirabilis clinical strains: BioProject ID: PRJNA979110. |
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7160 |
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Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strainpodovirusesAcadevirusdepolymerasesCAUTIProteus mirabilisNCBI Accession numbers: Proteus phage BigMira-UFV01: OQ729741; Proteus phage MidiMira-UFV02; OQ729742; P. mirabilis clinical strains: BioProject ID: PRJNA979110.Proteus mirabilis is an opportunistic pathogen and is responsible for more than 40% of all cases of catheter-associated urinary tract infections (CAUTIs). Healthcare-associated infections have been aggravated by the constant emergence of antibiotic-resistant bacterial strains. Because of this, the use of phages to combat bacterial infections gained renewed interest. In this study, we describe the biological and genomic features of two P. mirabilis phages, named BigMira and MidiMira. These phages belong to the Acadevirus genus (family Autographiviridae). BigMira and MidiMira are highly similar, differing only in four missense mutations in their phage tail fiber. These mutations are sufficient to impact the phages’ depolymerase activity. Subsequently, the comparative genomic analysis of ten clinical P. mirabilis strains revealed differences in their antibiotic resistance profiles and lipopolysaccharide locus, with the latter potentially explaining the host range data of the phages. The massive presence of antimicrobial resistance genes, especially in the phages’ isolation strain P. mirabilis MCS, highlights the challenges in treating infections caused by multidrug-resistant bacteria. The findings reinforce BigMira and MidiMira phages as candidates for phage therapy purposes.ZDK was supported by the National Science Centre, Poland (grant UMO-2017/26/M/NZ1/00233). LDRM was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and through the Scientific Employment Stimulus Program (2021.00221.CEECIND).info:eu-repo/semantics/publishedVersionMDPIUniversidade do Minhoda Silva, Jéssica DuarteBens, LeneSantos, Adriele J. do CarmoLavigne, RobSoares, JoséMelo, Luís Daniel RodriguesVallino, MartaDias, Roberto SousaDrulis-Kawa, Zuzannade Paula, Sérgio OliveiraWagemans, Jeroen2023-08-232023-08-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/86409engda Silva, J.D.; Bens, L.; Santos, A.J.d.C.; Lavigne, R.; Soares, J.; Melo, L.D.R.; Vallino, M.; Dias, R.S.; Drulis-Kawa, Z.; de Paula, S.O.; et al. Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain. Microorganisms 2023, 11, 2141. https://doi.org/10.3390/microorganisms110921412076-260710.3390/microorganisms11092141https://www.mdpi.com/2076-2607/11/9/2141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-23T01:18:53Zoai:repositorium.sdum.uminho.pt:1822/86409Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:30:42.478330Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
title |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
spellingShingle |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain da Silva, Jéssica Duarte podoviruses Acadevirus depolymerases CAUTI Proteus mirabilis |
title_short |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
title_full |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
title_fullStr |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
title_full_unstemmed |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
title_sort |
Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain |
author |
da Silva, Jéssica Duarte |
author_facet |
da Silva, Jéssica Duarte Bens, Lene Santos, Adriele J. do Carmo Lavigne, Rob Soares, José Melo, Luís Daniel Rodrigues Vallino, Marta Dias, Roberto Sousa Drulis-Kawa, Zuzanna de Paula, Sérgio Oliveira Wagemans, Jeroen |
author_role |
author |
author2 |
Bens, Lene Santos, Adriele J. do Carmo Lavigne, Rob Soares, José Melo, Luís Daniel Rodrigues Vallino, Marta Dias, Roberto Sousa Drulis-Kawa, Zuzanna de Paula, Sérgio Oliveira Wagemans, Jeroen |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
da Silva, Jéssica Duarte Bens, Lene Santos, Adriele J. do Carmo Lavigne, Rob Soares, José Melo, Luís Daniel Rodrigues Vallino, Marta Dias, Roberto Sousa Drulis-Kawa, Zuzanna de Paula, Sérgio Oliveira Wagemans, Jeroen |
dc.subject.por.fl_str_mv |
podoviruses Acadevirus depolymerases CAUTI Proteus mirabilis |
topic |
podoviruses Acadevirus depolymerases CAUTI Proteus mirabilis |
description |
NCBI Accession numbers: Proteus phage BigMira-UFV01: OQ729741; Proteus phage MidiMira-UFV02; OQ729742; P. mirabilis clinical strains: BioProject ID: PRJNA979110. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-23 2023-08-23T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/86409 |
url |
https://hdl.handle.net/1822/86409 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
da Silva, J.D.; Bens, L.; Santos, A.J.d.C.; Lavigne, R.; Soares, J.; Melo, L.D.R.; Vallino, M.; Dias, R.S.; Drulis-Kawa, Z.; de Paula, S.O.; et al. Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain. Microorganisms 2023, 11, 2141. https://doi.org/10.3390/microorganisms11092141 2076-2607 10.3390/microorganisms11092141 https://www.mdpi.com/2076-2607/11/9/2141 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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