Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/160048 |
Resumo: | © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. |
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Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on HaemodialysisPTHchronic kidney disease–mineral and bone disorders (CKD-MBD)diabeteshaemodialysismortalitySDG 3 - Good Health and Well-being© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.BACKGROUND: Diabetic patients on haemodialysis have a higher risk of mortality than non-diabetic patients. The aim of this COSMOS analysis was to assess whether bone and mineral laboratory values (calcium, phosphorus, and PTH) contribute to such risk. METHODS: COSMOS is a multicentre, open-cohort, 3-year prospective study, which includes 6797 patients from 227 randomly selected dialysis centres from 20 European countries. The association between mortality and calcium, phosphate or PTH was assessed using Cox proportional hazard regression models using both penalized splines smoothing and categorization according to KDIGO guidelines. The effect modification of the association between the relative risk of mortality and serum calcium, phosphate or PTH by diabetes was assessed. RESULTS: There was a statistically significant effect modification of the association between the relative risk of mortality and serum PTH by diabetes (p = 0.011). The slope of the curve of the association between increasing values of PTH and relative risk of mortality was steeper for diabetic compared with non-diabetic patients, mainly for high levels of PTH. In addition, high serum PTH (> 9 times the normal values) was significantly associated with a higher relative risk of mortality in diabetic patients but not in non-diabetic patients (1.53[95%CI:1.07-2.19] and 1.17[95%CI:0.91-1.52]). No significant effect modification of the association between the relative risk of mortality and serum calcium or phosphate by diabetes was found (p = 0.2 and p = 0.059, respectively). CONCLUSION: The results show a different association of PTH with the relative risk of mortality in diabetic and non-diabetic patients. These findings could have relevant implications for the diagnosis and treatment of CKD-MBD.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMartín-Carro, BeatrizNavarro-González, Juan FranciscoOrtiz, AlbertoZoccali, CarmineFloege, JürgenFerreira, Manuel AníbalGorriz-Teruel, José LuisCarrillo-López, NataliaPanizo, SaraLocatelli, FrancescoKetteler, MarkusLondon, Gerard MichelNaves-Díaz, ManuelAlonso-Montes, CristinaCannata-Andia, Jorge BenitoFernández-Martín, José Luis2023-11-16T22:09:45Z2023-10-312023-10-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160048eng0931-0509PURE: 74249000https://doi.org/10.1093/ndt/gfad122info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:35Zoai:run.unl.pt:10362/160048Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:50.158599Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| title |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| spellingShingle |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis Martín-Carro, Beatriz PTH chronic kidney disease–mineral and bone disorders (CKD-MBD) diabetes haemodialysis mortality SDG 3 - Good Health and Well-being |
| title_short |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| title_full |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| title_fullStr |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| title_full_unstemmed |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| title_sort |
Mineral and Bone Metabolism Markers and Mortality in Diabetic Patients on Haemodialysis |
| author |
Martín-Carro, Beatriz |
| author_facet |
Martín-Carro, Beatriz Navarro-González, Juan Francisco Ortiz, Alberto Zoccali, Carmine Floege, Jürgen Ferreira, Manuel Aníbal Gorriz-Teruel, José Luis Carrillo-López, Natalia Panizo, Sara Locatelli, Francesco Ketteler, Markus London, Gerard Michel Naves-Díaz, Manuel Alonso-Montes, Cristina Cannata-Andia, Jorge Benito Fernández-Martín, José Luis |
| author_role |
author |
| author2 |
Navarro-González, Juan Francisco Ortiz, Alberto Zoccali, Carmine Floege, Jürgen Ferreira, Manuel Aníbal Gorriz-Teruel, José Luis Carrillo-López, Natalia Panizo, Sara Locatelli, Francesco Ketteler, Markus London, Gerard Michel Naves-Díaz, Manuel Alonso-Montes, Cristina Cannata-Andia, Jorge Benito Fernández-Martín, José Luis |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Martín-Carro, Beatriz Navarro-González, Juan Francisco Ortiz, Alberto Zoccali, Carmine Floege, Jürgen Ferreira, Manuel Aníbal Gorriz-Teruel, José Luis Carrillo-López, Natalia Panizo, Sara Locatelli, Francesco Ketteler, Markus London, Gerard Michel Naves-Díaz, Manuel Alonso-Montes, Cristina Cannata-Andia, Jorge Benito Fernández-Martín, José Luis |
| dc.subject.por.fl_str_mv |
PTH chronic kidney disease–mineral and bone disorders (CKD-MBD) diabetes haemodialysis mortality SDG 3 - Good Health and Well-being |
| topic |
PTH chronic kidney disease–mineral and bone disorders (CKD-MBD) diabetes haemodialysis mortality SDG 3 - Good Health and Well-being |
| description |
© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-16T22:09:45Z 2023-10-31 2023-10-31T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/160048 |
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http://hdl.handle.net/10362/160048 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0931-0509 PURE: 74249000 https://doi.org/10.1093/ndt/gfad122 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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