Unravelling the dermatological potential of the brown seaweed Carpomitra costata

Detalhes bibliográficos
Autor(a) principal: Susano, Patrícia
Data de Publicação: 2021
Outros Autores: Silva, Joana, Alves, Celso, Martins, Alice, Gaspar, Helena, Pinteus, Susete, Mouga, Teresa, Goettert, Márcia Ines, Petrovski, Zeljko, Branco, Luís B., Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/5993
Resumo: This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre, UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, and FCT/MCTES (UIDB/50006/2020) granted to the Associate Laboratory for Green Chemistry-LAQV. The authors are also very grateful to financial support attained through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01-0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIAOUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017).
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spelling Unravelling the dermatological potential of the brown seaweed Carpomitra costataAlgaeAnti-enzymaticAnti-inflammatoryAntimicrobialAntioxidantMarine natural productsPhenolic compoundsPhotoprotectiveSkincareThis work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre, UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, and FCT/MCTES (UIDB/50006/2020) granted to the Associate Laboratory for Green Chemistry-LAQV. The authors are also very grateful to financial support attained through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01-0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIAOUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017).The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 g/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 g/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF- and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.MDPIIC-OnlineSusano, PatríciaSilva, JoanaAlves, CelsoMartins, AliceGaspar, HelenaPinteus, SuseteMouga, TeresaGoettert, Márcia InesPetrovski, ZeljkoBranco, Luís B.Pedrosa, Rui2021-08-03T12:13:46Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5993engSusano, P.; Silva, J.; Alves, C.; Martins, A.; Gaspar, H.; Pinteus, S.; Mouga, T.; Goettert, M.I.; Petrovski, Ž.; Branco, L.B.; et al. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Mar. Drugs 2021, 19, 135. https://doi.org/10.3390/md190301351660-339710.3390/md19030135info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-26T18:19:53Zoai:iconline.ipleiria.pt:10400.8/5993Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T18:19:53Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unravelling the dermatological potential of the brown seaweed Carpomitra costata
title Unravelling the dermatological potential of the brown seaweed Carpomitra costata
spellingShingle Unravelling the dermatological potential of the brown seaweed Carpomitra costata
Susano, Patrícia
Algae
Anti-enzymatic
Anti-inflammatory
Antimicrobial
Antioxidant
Marine natural products
Phenolic compounds
Photoprotective
Skincare
title_short Unravelling the dermatological potential of the brown seaweed Carpomitra costata
title_full Unravelling the dermatological potential of the brown seaweed Carpomitra costata
title_fullStr Unravelling the dermatological potential of the brown seaweed Carpomitra costata
title_full_unstemmed Unravelling the dermatological potential of the brown seaweed Carpomitra costata
title_sort Unravelling the dermatological potential of the brown seaweed Carpomitra costata
author Susano, Patrícia
author_facet Susano, Patrícia
Silva, Joana
Alves, Celso
Martins, Alice
Gaspar, Helena
Pinteus, Susete
Mouga, Teresa
Goettert, Márcia Ines
Petrovski, Zeljko
Branco, Luís B.
Pedrosa, Rui
author_role author
author2 Silva, Joana
Alves, Celso
Martins, Alice
Gaspar, Helena
Pinteus, Susete
Mouga, Teresa
Goettert, Márcia Ines
Petrovski, Zeljko
Branco, Luís B.
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Susano, Patrícia
Silva, Joana
Alves, Celso
Martins, Alice
Gaspar, Helena
Pinteus, Susete
Mouga, Teresa
Goettert, Márcia Ines
Petrovski, Zeljko
Branco, Luís B.
Pedrosa, Rui
dc.subject.por.fl_str_mv Algae
Anti-enzymatic
Anti-inflammatory
Antimicrobial
Antioxidant
Marine natural products
Phenolic compounds
Photoprotective
Skincare
topic Algae
Anti-enzymatic
Anti-inflammatory
Antimicrobial
Antioxidant
Marine natural products
Phenolic compounds
Photoprotective
Skincare
description This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre, UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, and FCT/MCTES (UIDB/50006/2020) granted to the Associate Laboratory for Green Chemistry-LAQV. The authors are also very grateful to financial support attained through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01-0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIAOUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017).
publishDate 2021
dc.date.none.fl_str_mv 2021-08-03T12:13:46Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/5993
url http://hdl.handle.net/10400.8/5993
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Susano, P.; Silva, J.; Alves, C.; Martins, A.; Gaspar, H.; Pinteus, S.; Mouga, T.; Goettert, M.I.; Petrovski, Ž.; Branco, L.B.; et al. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Mar. Drugs 2021, 19, 135. https://doi.org/10.3390/md19030135
1660-3397
10.3390/md19030135
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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