Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/56460 |
Resumo: | © 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
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Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver diseaseBarcelonaGLOBEPBCParisUDCAPredictorsPrimary biliary cholangitisResponseScoreUrsodeoxycholic acid© 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.Background: The current standard of treatment in primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA), although a considerable proportion of patients show incomplete response resulting in disease progression. Objective: This study aimed to assess the prevalence of incomplete response to UDCA and determine associated patients' characteristics. Methods: Patients with PBC as main diagnosis were included from a national multicentric patient registry-Liver.pt. Main endpoints included incomplete response to UDCA treatment according to Barcelona, Paris I and Paris II criteria, Globe and UK PBC scores and the association between baseline characteristics and incomplete response according to Paris II criteria. Results: A total of 434 PBC patients were identified, with a mean age of 55 years and 89.2% females. Nearly half of patients were asymptomatic at diagnosis and 93.2% had positive anti-mitochondrial antibodies. Almost all patients (95.6%) had been prescribed at least one drug for PBC treatment. At the last follow-up visit, 93.3% were under treatment of which 99.8% received UDCA. Incomplete response to UDCA was observed in 30.7%, 35.3%, 53.7% and 36.4% of patients according to Barcelona, Paris I, Paris II criteria and Globe score, respectively. After adjusting for age and sex, and accordingly to Paris II criteria, the risk for incomplete biochemical response was 25% higher for patients with cirrhosis at diagnosis (odds ratio [OR] = 1.25; 95% confidence interval [95%CI]: 1.02-1.54; p = 0.033) and 35% (95%CI:1.06-1.72; p = 0.016) and 5% (OR = 1.05; 95%CI:1.01-1.10; p = 0.013) for those with elevated gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP). Conclusion: A considerable proportion of patients showed incomplete biochemical response to UDCA treatment according to Paris II criteria. Cirrhosis, elevated GGT and ALP at diagnosis were identified as associated risk factors for incomplete response. Early identification of patients at risk of incomplete response could improve treatment care and guide clinical decision to a more careful patient monitorization.WileyRepositório da Universidade de LisboaCortez-Pinto, HelenaLiberal, RodrigoLopes, SusanaMachado, MarianaCarvalho, JoanaDias, TeresaSantos, ArsénioAgostinho, CláudiaFigueiredo, PedroLoureiro, RafaelaMartins, AlexandraAlexandrino, GonçaloCotrim, IsabelLeal, CarinaPresa, JoséMesquita, MónicaNunes, JoanaGouveia, CatarinaVale, Ana Horta eAlves, Ana LuísaCoelho, MarianaMaia, LuísPedroto, IsabelBanhudo, AntónioPinto, João SebastiãoGomes, Marta VargasOliveira, JoanaAndreozzi, ValeskaCalinas, Filipe2023-02-24T17:10:04Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56460engUnited European Gastroenterol J. 2021 Jul;9(6):699-7062050-640610.1002/ueg2.120952050-6414info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:01Zoai:repositorio.ul.pt:10451/56460Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:58.491984Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| title |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| spellingShingle |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease Cortez-Pinto, Helena Barcelona GLOBE PBC Paris UDCA Predictors Primary biliary cholangitis Response Score Ursodeoxycholic acid |
| title_short |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| title_full |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| title_fullStr |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| title_full_unstemmed |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| title_sort |
Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease |
| author |
Cortez-Pinto, Helena |
| author_facet |
Cortez-Pinto, Helena Liberal, Rodrigo Lopes, Susana Machado, Mariana Carvalho, Joana Dias, Teresa Santos, Arsénio Agostinho, Cláudia Figueiredo, Pedro Loureiro, Rafaela Martins, Alexandra Alexandrino, Gonçalo Cotrim, Isabel Leal, Carina Presa, José Mesquita, Mónica Nunes, Joana Gouveia, Catarina Vale, Ana Horta e Alves, Ana Luísa Coelho, Mariana Maia, Luís Pedroto, Isabel Banhudo, António Pinto, João Sebastião Gomes, Marta Vargas Oliveira, Joana Andreozzi, Valeska Calinas, Filipe |
| author_role |
author |
| author2 |
Liberal, Rodrigo Lopes, Susana Machado, Mariana Carvalho, Joana Dias, Teresa Santos, Arsénio Agostinho, Cláudia Figueiredo, Pedro Loureiro, Rafaela Martins, Alexandra Alexandrino, Gonçalo Cotrim, Isabel Leal, Carina Presa, José Mesquita, Mónica Nunes, Joana Gouveia, Catarina Vale, Ana Horta e Alves, Ana Luísa Coelho, Mariana Maia, Luís Pedroto, Isabel Banhudo, António Pinto, João Sebastião Gomes, Marta Vargas Oliveira, Joana Andreozzi, Valeska Calinas, Filipe |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Cortez-Pinto, Helena Liberal, Rodrigo Lopes, Susana Machado, Mariana Carvalho, Joana Dias, Teresa Santos, Arsénio Agostinho, Cláudia Figueiredo, Pedro Loureiro, Rafaela Martins, Alexandra Alexandrino, Gonçalo Cotrim, Isabel Leal, Carina Presa, José Mesquita, Mónica Nunes, Joana Gouveia, Catarina Vale, Ana Horta e Alves, Ana Luísa Coelho, Mariana Maia, Luís Pedroto, Isabel Banhudo, António Pinto, João Sebastião Gomes, Marta Vargas Oliveira, Joana Andreozzi, Valeska Calinas, Filipe |
| dc.subject.por.fl_str_mv |
Barcelona GLOBE PBC Paris UDCA Predictors Primary biliary cholangitis Response Score Ursodeoxycholic acid |
| topic |
Barcelona GLOBE PBC Paris UDCA Predictors Primary biliary cholangitis Response Score Ursodeoxycholic acid |
| description |
© 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-02-24T17:10:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/56460 |
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http://hdl.handle.net/10451/56460 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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United European Gastroenterol J. 2021 Jul;9(6):699-706 2050-6406 10.1002/ueg2.12095 2050-6414 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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