Trapping metastatic cancer cells with mechanical ratchet arrays

Detalhes bibliográficos
Autor(a) principal: Caballero, David
Data de Publicação: 2023
Outros Autores: Reis, R. L., Kundu, Subhas C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/88599
Resumo: Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.actbio.2023.08.034.
id RCAP_7858c7decf785b35ed07f0c4ab60d5cc
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/88599
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Trapping metastatic cancer cells with mechanical ratchet arraysCancerDirected migrationmicrofabricationratchetTrapsSupplementary material associated with this article can be found, in the online version, at doi:10.1016/j.actbio.2023.08.034.Current treatments for cancer, such as chemotherapy, radiotherapy, immunotherapy, and surgery, have positive results but are generally ineffective against metastatic tumors. Treatment effectiveness can be improved by employing bioengineered cancer traps, typically utilizing chemoattractant-loaded materials, to attract infiltrating cancer cells preventing their uncontrolled spread and potentially enabling eradication. However, the encapsulated chemical compounds can have adverse effects on other cells causing unwanted responses, and the generated gradients can evolve unpredictably. Here, we report the development of a cancer trap based on mechanical ratchet structures to capture metastatic cells. The traps use an array of asymmetric local features to mechanically attract cancer cells and direct their migration for prolonged periods. The trapping efficiency was found to be greater than isotropic or inverse anisotropic ratchet structures on either disseminating cancer cells and tumor spheroids. Importantly, the traps exhibited a reduced effectiveness when targeting non-metastatic and non-tumorigenic cells, underscoring their particular suitability for capturing highly invasive cancer cells. Overall, this original approach may have therapeutic implications for fighting cancer, and may also be used to control cell motility for other biological processes.This research was funded by the Portuguese Foundation for Science and Technology (FCT) under the program CEEC Individual 2017 (CEECIND/00352/2017) and IC&DT (2022.02260.PTDC).ElsevierUniversidade do MinhoCaballero, DavidReis, R. L.Kundu, Subhas C2023-102023-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/88599engCaballero, D., Reis, R. L., & Kundu, S. C. (2023, October). Trapping metastatic cancer cells with mechanical ratchet arrays. Acta Biomaterialia. Elsevier BV. http://doi.org/10.1016/j.actbio.2023.08.0341878-756810.1016/j.actbio.2023.08.03437619895https://www.sciencedirect.com/science/article/pii/S1742706123004981info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-10T01:21:26Zoai:repositorium.sdum.uminho.pt:1822/88599Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:37:19.702946Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Trapping metastatic cancer cells with mechanical ratchet arrays
title Trapping metastatic cancer cells with mechanical ratchet arrays
spellingShingle Trapping metastatic cancer cells with mechanical ratchet arrays
Caballero, David
Cancer
Directed migration
microfabrication
ratchet
Traps
title_short Trapping metastatic cancer cells with mechanical ratchet arrays
title_full Trapping metastatic cancer cells with mechanical ratchet arrays
title_fullStr Trapping metastatic cancer cells with mechanical ratchet arrays
title_full_unstemmed Trapping metastatic cancer cells with mechanical ratchet arrays
title_sort Trapping metastatic cancer cells with mechanical ratchet arrays
author Caballero, David
author_facet Caballero, David
Reis, R. L.
Kundu, Subhas C
author_role author
author2 Reis, R. L.
Kundu, Subhas C
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Caballero, David
Reis, R. L.
Kundu, Subhas C
dc.subject.por.fl_str_mv Cancer
Directed migration
microfabrication
ratchet
Traps
topic Cancer
Directed migration
microfabrication
ratchet
Traps
description Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.actbio.2023.08.034.
publishDate 2023
dc.date.none.fl_str_mv 2023-10
2023-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/88599
url https://hdl.handle.net/1822/88599
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Caballero, D., Reis, R. L., & Kundu, S. C. (2023, October). Trapping metastatic cancer cells with mechanical ratchet arrays. Acta Biomaterialia. Elsevier BV. http://doi.org/10.1016/j.actbio.2023.08.034
1878-7568
10.1016/j.actbio.2023.08.034
37619895
https://www.sciencedirect.com/science/article/pii/S1742706123004981
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137423951659008

Registros relacionados