The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
DOI: | 10.3390/bioengineering9010015 |
Texto Completo: | http://hdl.handle.net/10316/103185 https://doi.org/10.3390/bioengineering9010015 |
Resumo: | Three-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, "Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?". The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies' risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient's fertility, which constitutes one of the largest groups of patients using these orthodontic devices. |
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The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review3D resinalignercytotoxicityestrogenicityinvisalignmonomerretainerThree-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, "Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?". The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies' risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient's fertility, which constitutes one of the largest groups of patients using these orthodontic devices.2022-01-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103185http://hdl.handle.net/10316/103185https://doi.org/10.3390/bioengineering9010015eng2306-5354Francisco, InêsPaula, Anabela BaptistaRibeiro, MadalenaMarques, FilipaTravassos, RaquelNunes, CatarinaPereira, FláviaMarto, Carlos MiguelCarrilho, EuniceVale, Franciscoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-20T20:31:45Zoai:estudogeral.uc.pt:10316/103185Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:03.764903Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
title |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
spellingShingle |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review Francisco, Inês 3D resin aligner cytotoxicity estrogenicity invisalign monomer retainer Francisco, Inês 3D resin aligner cytotoxicity estrogenicity invisalign monomer retainer |
title_short |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
title_full |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
title_fullStr |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
title_full_unstemmed |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
title_sort |
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review |
author |
Francisco, Inês |
author_facet |
Francisco, Inês Francisco, Inês Paula, Anabela Baptista Ribeiro, Madalena Marques, Filipa Travassos, Raquel Nunes, Catarina Pereira, Flávia Marto, Carlos Miguel Carrilho, Eunice Vale, Francisco Paula, Anabela Baptista Ribeiro, Madalena Marques, Filipa Travassos, Raquel Nunes, Catarina Pereira, Flávia Marto, Carlos Miguel Carrilho, Eunice Vale, Francisco |
author_role |
author |
author2 |
Paula, Anabela Baptista Ribeiro, Madalena Marques, Filipa Travassos, Raquel Nunes, Catarina Pereira, Flávia Marto, Carlos Miguel Carrilho, Eunice Vale, Francisco |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Francisco, Inês Paula, Anabela Baptista Ribeiro, Madalena Marques, Filipa Travassos, Raquel Nunes, Catarina Pereira, Flávia Marto, Carlos Miguel Carrilho, Eunice Vale, Francisco |
dc.subject.por.fl_str_mv |
3D resin aligner cytotoxicity estrogenicity invisalign monomer retainer |
topic |
3D resin aligner cytotoxicity estrogenicity invisalign monomer retainer |
description |
Three-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, "Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?". The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies' risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient's fertility, which constitutes one of the largest groups of patients using these orthodontic devices. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103185 http://hdl.handle.net/10316/103185 https://doi.org/10.3390/bioengineering9010015 |
url |
http://hdl.handle.net/10316/103185 https://doi.org/10.3390/bioengineering9010015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2306-5354 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1822183383183130624 |
dc.identifier.doi.none.fl_str_mv |
10.3390/bioengineering9010015 |