The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review

Detalhes bibliográficos
Autor(a) principal: Francisco, Inês
Data de Publicação: 2022
Outros Autores: Paula, Anabela Baptista, Ribeiro, Madalena, Marques, Filipa, Travassos, Raquel, Nunes, Catarina, Pereira, Flávia, Marto, Carlos Miguel, Carrilho, Eunice, Vale, Francisco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.3390/bioengineering9010015
Texto Completo: http://hdl.handle.net/10316/103185
https://doi.org/10.3390/bioengineering9010015
Resumo: Three-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, "Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?". The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies' risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient's fertility, which constitutes one of the largest groups of patients using these orthodontic devices.
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spelling The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review3D resinalignercytotoxicityestrogenicityinvisalignmonomerretainerThree-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, "Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?". The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies' risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient's fertility, which constitutes one of the largest groups of patients using these orthodontic devices.2022-01-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103185http://hdl.handle.net/10316/103185https://doi.org/10.3390/bioengineering9010015eng2306-5354Francisco, InêsPaula, Anabela BaptistaRibeiro, MadalenaMarques, FilipaTravassos, RaquelNunes, CatarinaPereira, FláviaMarto, Carlos MiguelCarrilho, EuniceVale, Franciscoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-20T20:31:45Zoai:estudogeral.uc.pt:10316/103185Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:03.764903Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
title The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
spellingShingle The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
Francisco, Inês
3D resin
aligner
cytotoxicity
estrogenicity
invisalign
monomer
retainer
Francisco, Inês
3D resin
aligner
cytotoxicity
estrogenicity
invisalign
monomer
retainer
title_short The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
title_full The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
title_fullStr The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
title_full_unstemmed The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
title_sort The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
author Francisco, Inês
author_facet Francisco, Inês
Francisco, Inês
Paula, Anabela Baptista
Ribeiro, Madalena
Marques, Filipa
Travassos, Raquel
Nunes, Catarina
Pereira, Flávia
Marto, Carlos Miguel
Carrilho, Eunice
Vale, Francisco
Paula, Anabela Baptista
Ribeiro, Madalena
Marques, Filipa
Travassos, Raquel
Nunes, Catarina
Pereira, Flávia
Marto, Carlos Miguel
Carrilho, Eunice
Vale, Francisco
author_role author
author2 Paula, Anabela Baptista
Ribeiro, Madalena
Marques, Filipa
Travassos, Raquel
Nunes, Catarina
Pereira, Flávia
Marto, Carlos Miguel
Carrilho, Eunice
Vale, Francisco
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Francisco, Inês
Paula, Anabela Baptista
Ribeiro, Madalena
Marques, Filipa
Travassos, Raquel
Nunes, Catarina
Pereira, Flávia
Marto, Carlos Miguel
Carrilho, Eunice
Vale, Francisco
dc.subject.por.fl_str_mv 3D resin
aligner
cytotoxicity
estrogenicity
invisalign
monomer
retainer
topic 3D resin
aligner
cytotoxicity
estrogenicity
invisalign
monomer
retainer
description Three-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, "Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?". The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies' risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient's fertility, which constitutes one of the largest groups of patients using these orthodontic devices.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103185
http://hdl.handle.net/10316/103185
https://doi.org/10.3390/bioengineering9010015
url http://hdl.handle.net/10316/103185
https://doi.org/10.3390/bioengineering9010015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2306-5354
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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dc.identifier.doi.none.fl_str_mv 10.3390/bioengineering9010015