HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013

Detalhes bibliográficos
Autor(a) principal: Mlakar, Jana
Data de Publicação: 2023
Outros Autores: Lunar, Maja M., Abecasis, Ana B., Vandamme, Anne Mieke, Tomažič, Janez, Vovko, Tomaž D., Pečavar, Blaž, Turel, Gabriele, Poljak, Mario
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/164560
Resumo: Funding Information: The research leading to these results received funding from the Slovenian Research Agency [grant number P3-0083] and Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana. Publisher Copyright: © 2023, Slovene Medical Society. All rights reserved.
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spelling HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013Central EuropeHIV-1molecular epidemiologynon-B subtypephylogenysubtypingQR MicrobiologyQR355 VirologyRM Therapeutics. PharmacologyRA0421 Public health. Hygiene. Preventive MedicineInfectious DiseasesVirologyImmunology and Microbiology(all)EpidemiologySDG 3 - Good Health and Well-beingFunding Information: The research leading to these results received funding from the Slovenian Research Agency [grant number P3-0083] and Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana. Publisher Copyright: © 2023, Slovene Medical Society. All rights reserved.Introduction: Disease progression, drug resistance mutations, and treatment strategies may vary by HIV-1 subtype. This study determined HIV-1 subtypes circulating in Slovenia, a Central European country with an HIV-1 epidemic driven by men who have sex with men, focusing on molecular epidemiology of non-B subtypes. Methods: A total of 367 HIV-1 sequences were included. Subtype was assigned by employing eight different HIV subtyping tools coupled with maximum likelihood phylogenetic analyses. Results: The subtyping tools COMET, jpHMM, and REGA 3.0 exhibited the best performance on the dataset studied. Phylogenetic analyses showed a 14.7% prevalence of non-B subtypes, with subtype A detected most frequently (4.9%), followed by CRF02_AG (2.4%), subtype C (1.1%), subtypes D, G, and CRF01_AE (0.8% each), and subtypes F and CRF22_01A1 (0.3% each). A subtype could not be assigned to 12 sequences (3.3%), indicating potential unique recombinant forms. Non-B subtypes were significantly associated with a heterosexual route of transmission and infection acquired in Eastern Europe, Africa, or Asia. Conclusions: In a country where subtype B is predominant, non-B subtypes were observed in one out of seven patients, a non-negligible proportion, which underlines the importance of systematic surveillance of HIV subtype diversity and the corresponding molecular epidemiology.TB, HIV and opportunistic diseases and pathogens (THOP)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)RUNMlakar, JanaLunar, Maja M.Abecasis, Ana B.Vandamme, Anne MiekeTomažič, JanezVovko, Tomaž D.Pečavar, BlažTurel, GabrielePoljak, Mario2024-03-06T23:41:22Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/164560eng1318-4458PURE: 83821237https://doi.org/10.15570/actaapa.2023.20info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:53:06Zoai:run.unl.pt:10362/164560Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:14.973122Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
title HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
spellingShingle HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
Mlakar, Jana
Central Europe
HIV-1
molecular epidemiology
non-B subtype
phylogeny
subtyping
QR Microbiology
QR355 Virology
RM Therapeutics. Pharmacology
RA0421 Public health. Hygiene. Preventive Medicine
Infectious Diseases
Virology
Immunology and Microbiology(all)
Epidemiology
SDG 3 - Good Health and Well-being
title_short HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
title_full HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
title_fullStr HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
title_full_unstemmed HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
title_sort HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013
author Mlakar, Jana
author_facet Mlakar, Jana
Lunar, Maja M.
Abecasis, Ana B.
Vandamme, Anne Mieke
Tomažič, Janez
Vovko, Tomaž D.
Pečavar, Blaž
Turel, Gabriele
Poljak, Mario
author_role author
author2 Lunar, Maja M.
Abecasis, Ana B.
Vandamme, Anne Mieke
Tomažič, Janez
Vovko, Tomaž D.
Pečavar, Blaž
Turel, Gabriele
Poljak, Mario
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv TB, HIV and opportunistic diseases and pathogens (THOP)
Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
RUN
dc.contributor.author.fl_str_mv Mlakar, Jana
Lunar, Maja M.
Abecasis, Ana B.
Vandamme, Anne Mieke
Tomažič, Janez
Vovko, Tomaž D.
Pečavar, Blaž
Turel, Gabriele
Poljak, Mario
dc.subject.por.fl_str_mv Central Europe
HIV-1
molecular epidemiology
non-B subtype
phylogeny
subtyping
QR Microbiology
QR355 Virology
RM Therapeutics. Pharmacology
RA0421 Public health. Hygiene. Preventive Medicine
Infectious Diseases
Virology
Immunology and Microbiology(all)
Epidemiology
SDG 3 - Good Health and Well-being
topic Central Europe
HIV-1
molecular epidemiology
non-B subtype
phylogeny
subtyping
QR Microbiology
QR355 Virology
RM Therapeutics. Pharmacology
RA0421 Public health. Hygiene. Preventive Medicine
Infectious Diseases
Virology
Immunology and Microbiology(all)
Epidemiology
SDG 3 - Good Health and Well-being
description Funding Information: The research leading to these results received funding from the Slovenian Research Agency [grant number P3-0083] and Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana. Publisher Copyright: © 2023, Slovene Medical Society. All rights reserved.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
2024-03-06T23:41:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/164560
url http://hdl.handle.net/10362/164560
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1318-4458
PURE: 83821237
https://doi.org/10.15570/actaapa.2023.20
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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