Hydrogels in acellular and cellular strategies for intervertebral disc regeneration

Bibliographic Details
Main Author: Pereira, D. R.
Publication Date: 2011
Other Authors: Silva-Correia, Joana, Oliveira, Joaquim M., Reis, R. L.
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/1822/14281
Summary: Article first published online: 9 nov. 2011
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spelling Hydrogels in acellular and cellular strategies for intervertebral disc regenerationAcellular ApproachBiomaterials-based TherapiesCellular ApproachHydrogelsIntervertebral DiscGellan GumTissue EngineeringRegenerative MedicineArticle first published online: 9 nov. 2011Low back pain is an extremely common illness syndrome causing patient’s suffering and disability which demands for urgent solutions in order to improve life quality of the patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The huge cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterials-based therapies are the most interesting solutions nowadays, wherein tissue engineering and regenerative medicine (TE&RM) strategies are included. By using such strategies, i.e., combining biomaterials, cells and biomolecules, the ultimate goal of reaching a complete integration between native and neo-tissue can be achieved. Hydrogels are promising materials to restore IVD, mainly nucleus pulposus (NP). Herein, an overview of the use of hydrogels in acellular and cellular strategies for intervertebral disc regeneration is presented. To better understand the IVD and its functioning, several topics will be focused, i.e., anatomy, pathophysiology, cellular and biomolecular performance, intrinsic healing processes and current therapies. In this review, the application of hydrogels as NP substitutes will be addressed, due to the similarity to NP mechanical properties and extracellular matrix. These hydrogels can be used in cellular strategies, when combined with cells from different sources,, or in acellular strategies, by performing the functionalization of the hydrogels with biomolecules. In addition, a brief summary of therapies based on simple injection envisaging primarily the biological repair will be tackled. At last, a special emphasis has been given to original works reporting the use of autologous cells and biomolecules (e.g.,Platelet-rich plasma) and envisioning the clinical application.Fundação para a Ciência e tecnologia (FCT) through POCTI and FEDER including Project Proteolight. European Union-funded Collaborative Project Disc RegenerationWileyUniversidade do MinhoPereira, D. R.Silva-Correia, JoanaOliveira, Joaquim M.Reis, R. L.20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/14281eng1932-7005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:00:53Zoai:repositorium.sdum.uminho.pt:1822/14281Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:50:46.332432Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
title Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
spellingShingle Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
Pereira, D. R.
Acellular Approach
Biomaterials-based Therapies
Cellular Approach
Hydrogels
Intervertebral Disc
Gellan Gum
Tissue Engineering
Regenerative Medicine
title_short Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
title_full Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
title_fullStr Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
title_full_unstemmed Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
title_sort Hydrogels in acellular and cellular strategies for intervertebral disc regeneration
author Pereira, D. R.
author_facet Pereira, D. R.
Silva-Correia, Joana
Oliveira, Joaquim M.
Reis, R. L.
author_role author
author2 Silva-Correia, Joana
Oliveira, Joaquim M.
Reis, R. L.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pereira, D. R.
Silva-Correia, Joana
Oliveira, Joaquim M.
Reis, R. L.
dc.subject.por.fl_str_mv Acellular Approach
Biomaterials-based Therapies
Cellular Approach
Hydrogels
Intervertebral Disc
Gellan Gum
Tissue Engineering
Regenerative Medicine
topic Acellular Approach
Biomaterials-based Therapies
Cellular Approach
Hydrogels
Intervertebral Disc
Gellan Gum
Tissue Engineering
Regenerative Medicine
description Article first published online: 9 nov. 2011
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/14281
url http://hdl.handle.net/1822/14281
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-7005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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