Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma

Detalhes bibliográficos
Autor(a) principal: Ourô, Susana
Data de Publicação: 2020
Outros Autores: Mourato, Cláudia, Velho, Sónia, Cardador, André, Ferreira, Marisa P., Albergaria, Diogo, Castro, Rui E., Maio, Rui, Rodrigues, Cecília M.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/109478
Resumo: Funding: This work has received funding from European Structural and Investment Funds through the COMPETE Programme Grant LISBOA-01-0145-FEDER-016405, from National Funds through Fundação para a Ciência e Tecnologia Programme grant SAICTPAC/0019/2015 and by a cholar from the Portuguese Society of Coloproctology as Investigation in Coloproctology Research Prize 2016–2018.
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spelling Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinomabiomarkerschemoradiotherapy responsemiR-21rectal cancertumor regression gradeOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding: This work has received funding from European Structural and Investment Funds through the COMPETE Programme Grant LISBOA-01-0145-FEDER-016405, from National Funds through Fundação para a Ciência e Tecnologia Programme grant SAICTPAC/0019/2015 and by a cholar from the Portuguese Society of Coloproctology as Investigation in Coloproctology Research Prize 2016–2018.Background: Patients with locally advanced rectal adenocarcinoma (LARC) are treated with neoadjuvant chemoradiotherapy (CRT). However, biomarkers for patient selection are lacking, and the association between miRNA expression and treatment response and oncological outcomes is unclear. Objectives: To investigate miRNAs as predictors of response to neoadjuvant CRT and its association with oncological outcomes. Methods: This retrospective study analyzed miRNA expression (miR-16, miR-21, miR-135b, miR-145, and miR-335) in pre- and post-chemoradiation rectal adenocarcinoma tissue and non-neoplastic mucosa in 91 patients treated with neoadjuvant CRT (50.4 Gy) and proctectomy. Two groups were defined: a pathological complete responders group (tumor regression grade—TRG 0) and a pathological incomplete responders group (TRG 1, 2, and 3). Results: miR-21 and miR-135b were upregulated in tumor tissue of incomplete responders comparing with non-neoplastic tissue (p = 0.008 and p < 0.0001, respectively). Multivariate analysis showed significant association between miR-21 in pre-CRT tumor tissue and response, with a 3.67 odds ratio (OR) of incomplete response in patients with higher miR-21 levels (p = 0.04). Although with no significance, patients treated with 5-fluorouracil (5-FU) presented reduced odds of incomplete response compared with those treated with capecitabine (OR = 0.19; 95% confidence interval (CI) 0.03–1.12, p = 0.05). Moreover, significant differences were seen in overall survival (OS) in relation to clinical TNM stage (p = 0.0004), cT (p = 0.0001), presence of distant disease (p = 0.002), mesorectal tumor deposits (p = 0.003), and tumor regression grade (p = 0.04). Conclusion: miR-21 may predict response to CRT in rectal cancer (RC).NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNOurô, SusanaMourato, CláudiaVelho, SóniaCardador, AndréFerreira, Marisa P.Albergaria, DiogoCastro, Rui E.Maio, RuiRodrigues, Cecília M.P.2020-12-30T05:03:42Z2020-10-272020-10-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/109478engPURE: 26467205https://doi.org/10.3389/fonc.2020.577653info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:53:49Zoai:run.unl.pt:10362/109478Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:41:27.617290Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
title Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
spellingShingle Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
Ourô, Susana
biomarkers
chemoradiotherapy response
miR-21
rectal cancer
tumor regression grade
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
title_full Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
title_fullStr Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
title_full_unstemmed Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
title_sort Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma
author Ourô, Susana
author_facet Ourô, Susana
Mourato, Cláudia
Velho, Sónia
Cardador, André
Ferreira, Marisa P.
Albergaria, Diogo
Castro, Rui E.
Maio, Rui
Rodrigues, Cecília M.P.
author_role author
author2 Mourato, Cláudia
Velho, Sónia
Cardador, André
Ferreira, Marisa P.
Albergaria, Diogo
Castro, Rui E.
Maio, Rui
Rodrigues, Cecília M.P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ourô, Susana
Mourato, Cláudia
Velho, Sónia
Cardador, André
Ferreira, Marisa P.
Albergaria, Diogo
Castro, Rui E.
Maio, Rui
Rodrigues, Cecília M.P.
dc.subject.por.fl_str_mv biomarkers
chemoradiotherapy response
miR-21
rectal cancer
tumor regression grade
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic biomarkers
chemoradiotherapy response
miR-21
rectal cancer
tumor regression grade
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description Funding: This work has received funding from European Structural and Investment Funds through the COMPETE Programme Grant LISBOA-01-0145-FEDER-016405, from National Funds through Fundação para a Ciência e Tecnologia Programme grant SAICTPAC/0019/2015 and by a cholar from the Portuguese Society of Coloproctology as Investigation in Coloproctology Research Prize 2016–2018.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-30T05:03:42Z
2020-10-27
2020-10-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/109478
url http://hdl.handle.net/10362/109478
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 26467205
https://doi.org/10.3389/fonc.2020.577653
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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