Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer

Detalhes bibliográficos
Autor(a) principal: Ourô, Susana
Data de Publicação: 2020
Outros Autores: Mourato, Cláudia, Ferreira, Marisa P., Albergaria, Diogo, Cardador, André, Castro, Rui E., Maio, Rui, Rodrigues, Cecília M.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/106592
Resumo: This research received funding from European Structural & Investment Funds through the COMPETE Programme—Programa Operacional Regional de Lisboa—Programme Grant LISBOA-01-0145-FEDER-016405,and from National Funds through FCT—Fundação para a Ciência e a Tecnologia—Programme Grant SAICTPAC/0019/2015.
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spelling Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancerBiomarkersChemoradiotherapyMiR-21Rectal cancerTherapy responseTumor regression gradeMolecular MedicinePharmaceutical ScienceSDG 3 - Good Health and Well-beingThis research received funding from European Structural & Investment Funds through the COMPETE Programme—Programa Operacional Regional de Lisboa—Programme Grant LISBOA-01-0145-FEDER-016405,and from National Funds through FCT—Fundação para a Ciência e a Tecnologia—Programme Grant SAICTPAC/0019/2015.Response to chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (RC) is quite variable and it is urgent to find predictive biomarkers of response. We investigated miR-21 as tissue and plasma biomarker of response to CRT in a prospective cohort of RC patients; The expression of miR-21 was analyzed in pre-and post-CRT rectal tissue and plasma in 37 patients with RC. Two groups were defined: Pathological responders (TRG 0, 1 and 2) and non-responders (TRG 3). The association between miR-21, clinical and oncological outcomes was assessed; miR-21 was upregulated in tumor tissue and we found increased odds of overexpression in pre-CRT tumor tissue (OR: 1.63; 95% CI: 0.40–6.63, p = 0.498) and pre-CRT plasma (OR: 1.79; 95% CI: 0.45–7.19, p = 0.414) of non-responders. The overall recurrence risk increased with miR-21 overexpression in pre-CRT tumor tissue (HR: 2.175, p = 0.37); Significantly higher miR-21 expression is observed in tumor tissue comparing with non-neoplastic. Increased odds of non-response is reported in patients expressing higher miR-21, although without statistical significance. This is one of the first studies on circulating miR-21 as a potential biomarker of response to CRT in RC patients.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNOurô, SusanaMourato, CláudiaFerreira, Marisa P.Albergaria, DiogoCardador, AndréCastro, Rui E.Maio, RuiRodrigues, Cecília M.P.2020-11-03T23:59:11Z2020-092020-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/106592eng1424-8247PURE: 19928724https://doi.org/10.3390/ph13090246info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:51:28Zoai:run.unl.pt:10362/106592Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:44.605634Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
title Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
spellingShingle Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
Ourô, Susana
Biomarkers
Chemoradiotherapy
MiR-21
Rectal cancer
Therapy response
Tumor regression grade
Molecular Medicine
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
title_full Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
title_fullStr Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
title_full_unstemmed Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
title_sort Evaluation of tissue and circulating mir-21 as potential biomarker of response to chemoradiotherapy in rectal cancer
author Ourô, Susana
author_facet Ourô, Susana
Mourato, Cláudia
Ferreira, Marisa P.
Albergaria, Diogo
Cardador, André
Castro, Rui E.
Maio, Rui
Rodrigues, Cecília M.P.
author_role author
author2 Mourato, Cláudia
Ferreira, Marisa P.
Albergaria, Diogo
Cardador, André
Castro, Rui E.
Maio, Rui
Rodrigues, Cecília M.P.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ourô, Susana
Mourato, Cláudia
Ferreira, Marisa P.
Albergaria, Diogo
Cardador, André
Castro, Rui E.
Maio, Rui
Rodrigues, Cecília M.P.
dc.subject.por.fl_str_mv Biomarkers
Chemoradiotherapy
MiR-21
Rectal cancer
Therapy response
Tumor regression grade
Molecular Medicine
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Biomarkers
Chemoradiotherapy
MiR-21
Rectal cancer
Therapy response
Tumor regression grade
Molecular Medicine
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description This research received funding from European Structural & Investment Funds through the COMPETE Programme—Programa Operacional Regional de Lisboa—Programme Grant LISBOA-01-0145-FEDER-016405,and from National Funds through FCT—Fundação para a Ciência e a Tecnologia—Programme Grant SAICTPAC/0019/2015.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-03T23:59:11Z
2020-09
2020-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/106592
url http://hdl.handle.net/10362/106592
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1424-8247
PURE: 19928724
https://doi.org/10.3390/ph13090246
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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