Statin-associated necrotizing myopathy: a rare etiology

• Autor(a) principal: Moita,Catarina Ferreira
• Data de Publicação: 2020
• Outros Autores: Mendonça,Alexandra, Leite,Raquel Baptista, Vasconcellos,Ana Paes de, Dantas,Ana
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2182-51732020000600503
• topic: Myositis; Rhabdomyolysis; Hydroxymethylglutaryl-CoA reductase inhibitors; Autoantibodies.

Abstract Introduction: Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation. Case description: We report the case of a 72-year-old female with a 3-week-history of asthenia, increasing proximal tetraparesis, without pain, fever, or other symptoms, and elevated creatine kinase levels. Previous history was remarkable for dyslipidemia controlled with statin therapy. A muscular biopsy was performed, leading to the diagnosis of necrotizing myopathy. A body computed tomography (CT) scan was normal. Corticotherapy was initiated with progressive clinical and analytical improvement. Discussion: This case depicts an uncommon and underdiagnosed pathology which may be associated with statin treatment or cancer, that requires an early diagnosis and close follow-up for better clinical outcomes.