Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/23475 |
Resumo: | Previous studies have shown that haemodialysis patients have an increased risk of trace element imbalances. Most studies have determined the concentration of trace elements in serum only, but most trace elements are not uniformly distributed between plasma and blood cells, which justifies separate analysis of the different compartments. In this study, we determined both the serum and whole blood concentration of a wide panel of trace elements (Li, B, Mn, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Pb) in haemodialysis patients and compared them with those of a control group. Whole blood and serum samples were collected during routine laboratory testing of patients undergoing chronic haemodialysis. For comparison purposes, samples from individuals with normal renal function were also analysed. Statistically significant differences (p < 0.05) were found between the two groups for whole blood concentrations of all analysed elements except Zn (p = 0.347). For serum, the difference between groups was statistically significant for all elements (p < 0.05). This study confirms that patients on haemodialysis tend to present significant trace element imbalances. By determining the concentration of trace elements in both whole blood and serum, it was shown that chronic haemodialysis may affect intra- and extracellular blood compartments differently. |
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Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samplesHaemodialysiskidney failureTrace elementsICP-MSPrevious studies have shown that haemodialysis patients have an increased risk of trace element imbalances. Most studies have determined the concentration of trace elements in serum only, but most trace elements are not uniformly distributed between plasma and blood cells, which justifies separate analysis of the different compartments. In this study, we determined both the serum and whole blood concentration of a wide panel of trace elements (Li, B, Mn, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Pb) in haemodialysis patients and compared them with those of a control group. Whole blood and serum samples were collected during routine laboratory testing of patients undergoing chronic haemodialysis. For comparison purposes, samples from individuals with normal renal function were also analysed. Statistically significant differences (p < 0.05) were found between the two groups for whole blood concentrations of all analysed elements except Zn (p = 0.347). For serum, the difference between groups was statistically significant for all elements (p < 0.05). This study confirms that patients on haemodialysis tend to present significant trace element imbalances. By determining the concentration of trace elements in both whole blood and serum, it was shown that chronic haemodialysis may affect intra- and extracellular blood compartments differently.MDPIRepositório Científico do Instituto Politécnico do PortoAzevedo, RuiGennaro, DavideDuro, MaryPinto, EdgarAlmeida, Agostinho2023-09-07T15:56:40Z2023-04-152023-04-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23475engAzevedo, R., Gennaro, D., Duro, M., Pinto, E., & Almeida, A. (2023). Further Evidence on Trace Element Imbalances in Haemodialysis Patients—Paired Analysis of Blood and Serum Samples. Nutrients, 15(8), 1912. https://doi.org/10.3390/nu1508191210.3390/nu150819122072-6643info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-13T01:46:20Zoai:recipp.ipp.pt:10400.22/23475Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:29:00.823331Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
title |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
spellingShingle |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples Azevedo, Rui Haemodialysis kidney failure Trace elements ICP-MS |
title_short |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
title_full |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
title_fullStr |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
title_full_unstemmed |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
title_sort |
Further evidence on trace element imbalances in haemodialysis patients—paired analysis of blood and serum samples |
author |
Azevedo, Rui |
author_facet |
Azevedo, Rui Gennaro, Davide Duro, Mary Pinto, Edgar Almeida, Agostinho |
author_role |
author |
author2 |
Gennaro, Davide Duro, Mary Pinto, Edgar Almeida, Agostinho |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Azevedo, Rui Gennaro, Davide Duro, Mary Pinto, Edgar Almeida, Agostinho |
dc.subject.por.fl_str_mv |
Haemodialysis kidney failure Trace elements ICP-MS |
topic |
Haemodialysis kidney failure Trace elements ICP-MS |
description |
Previous studies have shown that haemodialysis patients have an increased risk of trace element imbalances. Most studies have determined the concentration of trace elements in serum only, but most trace elements are not uniformly distributed between plasma and blood cells, which justifies separate analysis of the different compartments. In this study, we determined both the serum and whole blood concentration of a wide panel of trace elements (Li, B, Mn, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Pb) in haemodialysis patients and compared them with those of a control group. Whole blood and serum samples were collected during routine laboratory testing of patients undergoing chronic haemodialysis. For comparison purposes, samples from individuals with normal renal function were also analysed. Statistically significant differences (p < 0.05) were found between the two groups for whole blood concentrations of all analysed elements except Zn (p = 0.347). For serum, the difference between groups was statistically significant for all elements (p < 0.05). This study confirms that patients on haemodialysis tend to present significant trace element imbalances. By determining the concentration of trace elements in both whole blood and serum, it was shown that chronic haemodialysis may affect intra- and extracellular blood compartments differently. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-07T15:56:40Z 2023-04-15 2023-04-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/23475 |
url |
http://hdl.handle.net/10400.22/23475 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Azevedo, R., Gennaro, D., Duro, M., Pinto, E., & Almeida, A. (2023). Further Evidence on Trace Element Imbalances in Haemodialysis Patients—Paired Analysis of Blood and Serum Samples. Nutrients, 15(8), 1912. https://doi.org/10.3390/nu15081912 10.3390/nu15081912 2072-6643 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133557710389248 |