Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H₂O₂ and superoxide dismutase activity

• Autor(a) principal: Mesquita, Ana Maria Macedo
• Data de Publicação: 2010
• Outros Autores: Weinberger, Martin, Silva, Alexandra, Marques, Belém Sampaio, Almeida, Bruno, Leão, Cecília, Costa, Vitor, Rodrigues, Fernando José dos Santos, Burhans, William C., Ludovico, Paula
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/1822/29335
• topic: Aging; Hydrogen peroxide; Hormesis; Antioxidant enzymes; Oxidative; oxidative damage; Science & Technology

The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases.