Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection

Detalhes bibliográficos
Autor(a) principal: Marques, Filipe
Data de Publicação: 2015
Outros Autores: Vale-Costa, Sílvia, Cruz, Tânia, Marques, Joana Moreira, Silva, Tânia, Neves, João Vilares, Cortes, Sofia, Fernandes, Ana, Rocha, Eduardo, Appelberg, Rui, Rodrigues, Pedro, Tomás, Ana M., Gomes, Maria Salomé
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/537
Resumo: Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and severe visceral disease. Visceral leishmaniasis is more frequent in immunocompromised individuals and data obtained in experimental models of infection have highlighted the importance of the host immune response, namely the efficient activation of host's macrophages, in determining infection outcome. Conversely, few studies have addressed a possible contribution of parasite variability to this outcome.
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spelling Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infectionLeishmania infantumVisceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and severe visceral disease. Visceral leishmaniasis is more frequent in immunocompromised individuals and data obtained in experimental models of infection have highlighted the importance of the host immune response, namely the efficient activation of host's macrophages, in determining infection outcome. Conversely, few studies have addressed a possible contribution of parasite variability to this outcome.BioMed CentralARCAMarques, FilipeVale-Costa, SílviaCruz, TâniaMarques, Joana MoreiraSilva, TâniaNeves, João VilaresCortes, SofiaFernandes, AnaRocha, EduardoAppelberg, RuiRodrigues, PedroTomás, Ana M.Gomes, Maria Salomé2015-12-21T17:16:05Z2015-122015-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/537eng10.1186/s13071-015-1259-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:19:20Zoai:arca.igc.gulbenkian.pt:10400.7/537Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:19:20Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
title Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
spellingShingle Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
Marques, Filipe
Leishmania infantum
title_short Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
title_full Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
title_fullStr Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
title_full_unstemmed Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
title_sort Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
author Marques, Filipe
author_facet Marques, Filipe
Vale-Costa, Sílvia
Cruz, Tânia
Marques, Joana Moreira
Silva, Tânia
Neves, João Vilares
Cortes, Sofia
Fernandes, Ana
Rocha, Eduardo
Appelberg, Rui
Rodrigues, Pedro
Tomás, Ana M.
Gomes, Maria Salomé
author_role author
author2 Vale-Costa, Sílvia
Cruz, Tânia
Marques, Joana Moreira
Silva, Tânia
Neves, João Vilares
Cortes, Sofia
Fernandes, Ana
Rocha, Eduardo
Appelberg, Rui
Rodrigues, Pedro
Tomás, Ana M.
Gomes, Maria Salomé
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Marques, Filipe
Vale-Costa, Sílvia
Cruz, Tânia
Marques, Joana Moreira
Silva, Tânia
Neves, João Vilares
Cortes, Sofia
Fernandes, Ana
Rocha, Eduardo
Appelberg, Rui
Rodrigues, Pedro
Tomás, Ana M.
Gomes, Maria Salomé
dc.subject.por.fl_str_mv Leishmania infantum
topic Leishmania infantum
description Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and severe visceral disease. Visceral leishmaniasis is more frequent in immunocompromised individuals and data obtained in experimental models of infection have highlighted the importance of the host immune response, namely the efficient activation of host's macrophages, in determining infection outcome. Conversely, few studies have addressed a possible contribution of parasite variability to this outcome.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-21T17:16:05Z
2015-12
2015-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/537
url http://hdl.handle.net/10400.7/537
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1186/s13071-015-1259-6
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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