A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/23082 |
Resumo: | Pharmacy personnel that manipulate cytotoxic drugs are under continuous exposure risk. Therefore, training and strict adherence to recommended practices should always be promoted. The main objective of this study was to develop and apply a safe, effective and low-cost method for the training and assessment of the safe handling of cytotoxic drugs, using commercially available tonic water. To evaluate the potential of tonic water as a replacement marker for quinine hydrochloride, deliberate spills of 1 mL of four different tonic waters (one coloured and three non-coloured) were analysed under ultraviolet light (300–400 nm). The pigmented sample did not produce fluorescence under ultraviolet (UV) light. The three commercially available tonic waters that exhibited fluorescence were further analysed by UV/Vis spectrophotometry (300–500 nm). Afterwards, a protocol of simulated manipulation of cytotoxic drugs was developed and applied to 12 pharmacy technicians, that prepared 24 intravenous bags according to recommended routine procedures using tonic water. Participants responded to a brief questionnaire to evaluate the adequacy and applicability of the activity. Seven of the participants had spillages during manipulation, the majority of which recorded during manipulation with needles. All participants scored the tonic water manipulation simulation with 4 or 5 points for simplicity, efficiency and feasibility. The obtained results suggest that tonic water can be used to simulate the manipulation of cytotoxic drugs in training and assessment programs. By using this replacement marker for quinine hydrochloride, it is possible to perform a more cost-effective, yet equally effective, assessment. |
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A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugsCytotoxic drugsAntineoplasticHazardous drugsOccupational exposurePharmacy personnel that manipulate cytotoxic drugs are under continuous exposure risk. Therefore, training and strict adherence to recommended practices should always be promoted. The main objective of this study was to develop and apply a safe, effective and low-cost method for the training and assessment of the safe handling of cytotoxic drugs, using commercially available tonic water. To evaluate the potential of tonic water as a replacement marker for quinine hydrochloride, deliberate spills of 1 mL of four different tonic waters (one coloured and three non-coloured) were analysed under ultraviolet light (300–400 nm). The pigmented sample did not produce fluorescence under ultraviolet (UV) light. The three commercially available tonic waters that exhibited fluorescence were further analysed by UV/Vis spectrophotometry (300–500 nm). Afterwards, a protocol of simulated manipulation of cytotoxic drugs was developed and applied to 12 pharmacy technicians, that prepared 24 intravenous bags according to recommended routine procedures using tonic water. Participants responded to a brief questionnaire to evaluate the adequacy and applicability of the activity. Seven of the participants had spillages during manipulation, the majority of which recorded during manipulation with needles. All participants scored the tonic water manipulation simulation with 4 or 5 points for simplicity, efficiency and feasibility. The obtained results suggest that tonic water can be used to simulate the manipulation of cytotoxic drugs in training and assessment programs. By using this replacement marker for quinine hydrochloride, it is possible to perform a more cost-effective, yet equally effective, assessment.SAGE JournalsRepositório Científico do Instituto Politécnico do PortoAli, NuroCarmo, HelenaRobalo, RaquelRocha, LuísaFernandes, CristinaMoreira, Fernando2023-06-07T10:16:23Z2023-05-072023-05-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23082engAli N, Carmo H, Robalo R, Rocha L, Fernandes C, Moreira F. A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs. Journal of Oncology Pharmacy Practice. 2023;0(0). doi:10.1177/107815522311738781078-155210.1177/107815522311731477-092Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-14T01:46:40Zoai:recipp.ipp.pt:10400.22/23082Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:00:23.929553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
title |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
spellingShingle |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs Ali, Nuro Cytotoxic drugs Antineoplastic Hazardous drugs Occupational exposure |
title_short |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
title_full |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
title_fullStr |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
title_full_unstemmed |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
title_sort |
A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs |
author |
Ali, Nuro |
author_facet |
Ali, Nuro Carmo, Helena Robalo, Raquel Rocha, Luísa Fernandes, Cristina Moreira, Fernando |
author_role |
author |
author2 |
Carmo, Helena Robalo, Raquel Rocha, Luísa Fernandes, Cristina Moreira, Fernando |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Ali, Nuro Carmo, Helena Robalo, Raquel Rocha, Luísa Fernandes, Cristina Moreira, Fernando |
dc.subject.por.fl_str_mv |
Cytotoxic drugs Antineoplastic Hazardous drugs Occupational exposure |
topic |
Cytotoxic drugs Antineoplastic Hazardous drugs Occupational exposure |
description |
Pharmacy personnel that manipulate cytotoxic drugs are under continuous exposure risk. Therefore, training and strict adherence to recommended practices should always be promoted. The main objective of this study was to develop and apply a safe, effective and low-cost method for the training and assessment of the safe handling of cytotoxic drugs, using commercially available tonic water. To evaluate the potential of tonic water as a replacement marker for quinine hydrochloride, deliberate spills of 1 mL of four different tonic waters (one coloured and three non-coloured) were analysed under ultraviolet light (300–400 nm). The pigmented sample did not produce fluorescence under ultraviolet (UV) light. The three commercially available tonic waters that exhibited fluorescence were further analysed by UV/Vis spectrophotometry (300–500 nm). Afterwards, a protocol of simulated manipulation of cytotoxic drugs was developed and applied to 12 pharmacy technicians, that prepared 24 intravenous bags according to recommended routine procedures using tonic water. Participants responded to a brief questionnaire to evaluate the adequacy and applicability of the activity. Seven of the participants had spillages during manipulation, the majority of which recorded during manipulation with needles. All participants scored the tonic water manipulation simulation with 4 or 5 points for simplicity, efficiency and feasibility. The obtained results suggest that tonic water can be used to simulate the manipulation of cytotoxic drugs in training and assessment programs. By using this replacement marker for quinine hydrochloride, it is possible to perform a more cost-effective, yet equally effective, assessment. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-07T10:16:23Z 2023-05-07 2023-05-07T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/23082 |
url |
http://hdl.handle.net/10400.22/23082 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ali N, Carmo H, Robalo R, Rocha L, Fernandes C, Moreira F. A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs. Journal of Oncology Pharmacy Practice. 2023;0(0). doi:10.1177/10781552231173878 1078-1552 10.1177/10781552231173 1477-092X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SAGE Journals |
publisher.none.fl_str_mv |
SAGE Journals |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131673232670720 |