Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)

Detalhes bibliográficos
Autor(a) principal: Teslić, Nemanja
Data de Publicação: 2022
Outros Autores: Santos, Filipa, Oliveira, Filipe, Stupar, Alena, Pojić, Milica, Mandić, Anamarija, Pavlić, Branimir, Kljakić, Aleksandra Cvetanović, Duarte, Ana Rita C., Paiva, Alexandre, Mišan, Aleksandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143496
Resumo: Grant No. 451-03-9/2021-14/ 200222 Grant no ERC-2016-CoG 72503
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spelling Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)Acidic NADESBy-product valorizationEllagic acidHydrolysis and extractionFood SciencePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingGrant No. 451-03-9/2021-14/ 200222 Grant no ERC-2016-CoG 72503Defatted raspberry seeds were used as an alternative source of antioxidants and ellagic acid (EA) extracted using Natural deep eutectic solvents (NADES). In the preliminary study, the best NADES combination (citric acid-betaine) and the most influential variables (temperature, time, and NADES/plant ratio) were selected for the further optimization process. All samples were analyzed in terms of total polyphenol, EA content, and antioxidant activity. Two sets of optimal conditions were generated by response surface methodology. The first set (Opt1) was designed for higher conversion of ellagitannins to EA while the latter set (Opt2) for higher EA content/100 g extract. Opt1 and Opt2 had higher values for all investigated responses compared to 80% ethanolic extract but had a lower conversion rate of ellagitannins to EA compared to acidified methanol extract. The third set of parameters (Opt3) selected beyond the initial experimental domain was used to obtain a sample with the highest EA content/100 g extract. Due to their nature, NADES extracts are ready to use and could have various technological roles in products since they are antioxidants, acidifiers, and colorants. NADES raspberry extracts exhibited higher anti-proliferative activity compared to ethanolic extracts in terms of EC50 values. However, the main contributor of anti-cancer activity in NADES raspberry extracts were individual NADES compounds and/or their newly formed NADES structure.DQ - Departamento de QuímicaLAQV@REQUIMTERUNTeslić, NemanjaSantos, FilipaOliveira, FilipeStupar, AlenaPojić, MilicaMandić, AnamarijaPavlić, BranimirKljakić, Aleksandra CvetanovićDuarte, Ana Rita C.Paiva, AlexandreMišan, Aleksandra2022-09-05T22:24:47Z2022-01-282022-01-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article19application/pdfhttp://hdl.handle.net/10362/143496eng2076-3921PURE: 46287868https://doi.org/10.3390/antiox11020254info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:21:51Zoai:run.unl.pt:10362/143496Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:58.083671Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
title Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
spellingShingle Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
Teslić, Nemanja
Acidic NADES
By-product valorization
Ellagic acid
Hydrolysis and extraction
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
title_short Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
title_full Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
title_fullStr Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
title_full_unstemmed Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
title_sort Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)
author Teslić, Nemanja
author_facet Teslić, Nemanja
Santos, Filipa
Oliveira, Filipe
Stupar, Alena
Pojić, Milica
Mandić, Anamarija
Pavlić, Branimir
Kljakić, Aleksandra Cvetanović
Duarte, Ana Rita C.
Paiva, Alexandre
Mišan, Aleksandra
author_role author
author2 Santos, Filipa
Oliveira, Filipe
Stupar, Alena
Pojić, Milica
Mandić, Anamarija
Pavlić, Branimir
Kljakić, Aleksandra Cvetanović
Duarte, Ana Rita C.
Paiva, Alexandre
Mišan, Aleksandra
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Teslić, Nemanja
Santos, Filipa
Oliveira, Filipe
Stupar, Alena
Pojić, Milica
Mandić, Anamarija
Pavlić, Branimir
Kljakić, Aleksandra Cvetanović
Duarte, Ana Rita C.
Paiva, Alexandre
Mišan, Aleksandra
dc.subject.por.fl_str_mv Acidic NADES
By-product valorization
Ellagic acid
Hydrolysis and extraction
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
topic Acidic NADES
By-product valorization
Ellagic acid
Hydrolysis and extraction
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
description Grant No. 451-03-9/2021-14/ 200222 Grant no ERC-2016-CoG 72503
publishDate 2022
dc.date.none.fl_str_mv 2022-09-05T22:24:47Z
2022-01-28
2022-01-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143496
url http://hdl.handle.net/10362/143496
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 46287868
https://doi.org/10.3390/antiox11020254
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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