PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

Detalhes bibliográficos
Autor(a) principal: Joana Matos
Data de Publicação: 2010
Outros Autores: Nuno Vale, Margaret S Collins, Jiri Gut, Philip J Rosenthal, Melanie T Cushion, Rui Moreira, Paula Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/82086
Resumo: Primacenes, novel ferrocene-primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.
id RCAP_8065cf9aed40b3e6cb564179ac4a29f4
oai_identifier_str oai:repositorio-aberto.up.pt:10216/82086
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activityQuímicaChemical sciencesPrimacenes, novel ferrocene-primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/82086eng2040-250310.1039/c0md00082eJoana MatosNuno ValeMargaret S CollinsJiri GutPhilip J RosenthalMelanie T CushionRui MoreiraPaula Gomesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:26:13Zoai:repositorio-aberto.up.pt:10216/82086Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:40:26.147764Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
title PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
spellingShingle PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
Joana Matos
Química
Chemical sciences
title_short PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
title_full PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
title_fullStr PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
title_full_unstemmed PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
title_sort PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
author Joana Matos
author_facet Joana Matos
Nuno Vale
Margaret S Collins
Jiri Gut
Philip J Rosenthal
Melanie T Cushion
Rui Moreira
Paula Gomes
author_role author
author2 Nuno Vale
Margaret S Collins
Jiri Gut
Philip J Rosenthal
Melanie T Cushion
Rui Moreira
Paula Gomes
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Joana Matos
Nuno Vale
Margaret S Collins
Jiri Gut
Philip J Rosenthal
Melanie T Cushion
Rui Moreira
Paula Gomes
dc.subject.por.fl_str_mv Química
Chemical sciences
topic Química
Chemical sciences
description Primacenes, novel ferrocene-primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/82086
url https://repositorio-aberto.up.pt/handle/10216/82086
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2040-2503
10.1039/c0md00082e
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135718737444864

Registros relacionados