Natural melanin: A potential pH-responsive drug release device

Detalhes bibliográficos
Autor(a) principal: Araújo, Marco
Data de Publicação: 2014
Outros Autores: Viveiros, Raquel, Correia, Tiago R., Correia, Ilídio Joaquim Sobreira, Bonifácio, Vasco, Casimiro, Teresa, Ricardo, Ana Aguiar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4648
Resumo: This work proposes melanin as a new nanocarrier for pH-responsive drug release. Melanin is an abundant natural polymer that can be easily extracted from cuttlefish as nanoparticles with a suitable size range for drug delivery. However, despite its high potentiality, the application of this biopolymer in the pharmaceutical and biomedical fields is yet to be explored. Herein, melanin nanoparticles were impregnated with metronidazole, chosen as model antibiotic drug, using supercritical carbon dioxide. The drug release profile was investigated at acidic and physiologic pH, and the dominant mechanism was found to follow a non-Fickian transport. Drug release from melanin shows a strong pH dependency, which allied to its biocompatibility and lack of cytotoxicity envisages its potential application as nanocarrier in formulations for colon and intestine targeted drug delivery.
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spelling Natural melanin: A potential pH-responsive drug release deviceMelaninPH-responsive drug releaseNanocarrierBiocompatibilitySupercritical carbon dioxideThis work proposes melanin as a new nanocarrier for pH-responsive drug release. Melanin is an abundant natural polymer that can be easily extracted from cuttlefish as nanoparticles with a suitable size range for drug delivery. However, despite its high potentiality, the application of this biopolymer in the pharmaceutical and biomedical fields is yet to be explored. Herein, melanin nanoparticles were impregnated with metronidazole, chosen as model antibiotic drug, using supercritical carbon dioxide. The drug release profile was investigated at acidic and physiologic pH, and the dominant mechanism was found to follow a non-Fickian transport. Drug release from melanin shows a strong pH dependency, which allied to its biocompatibility and lack of cytotoxicity envisages its potential application as nanocarrier in formulations for colon and intestine targeted drug delivery.ElsevieruBibliorumAraújo, MarcoViveiros, RaquelCorreia, Tiago R.Correia, Ilídio Joaquim SobreiraBonifácio, VascoCasimiro, TeresaRicardo, Ana Aguiar2018-03-20T10:32:39Z2014-04-232014-04-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4648eng10.1016/j.ijpharm.2014.04.051metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:41:50Zoai:ubibliorum.ubi.pt:10400.6/4648Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:42.520517Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Natural melanin: A potential pH-responsive drug release device
title Natural melanin: A potential pH-responsive drug release device
spellingShingle Natural melanin: A potential pH-responsive drug release device
Araújo, Marco
Melanin
PH-responsive drug release
Nanocarrier
Biocompatibility
Supercritical carbon dioxide
title_short Natural melanin: A potential pH-responsive drug release device
title_full Natural melanin: A potential pH-responsive drug release device
title_fullStr Natural melanin: A potential pH-responsive drug release device
title_full_unstemmed Natural melanin: A potential pH-responsive drug release device
title_sort Natural melanin: A potential pH-responsive drug release device
author Araújo, Marco
author_facet Araújo, Marco
Viveiros, Raquel
Correia, Tiago R.
Correia, Ilídio Joaquim Sobreira
Bonifácio, Vasco
Casimiro, Teresa
Ricardo, Ana Aguiar
author_role author
author2 Viveiros, Raquel
Correia, Tiago R.
Correia, Ilídio Joaquim Sobreira
Bonifácio, Vasco
Casimiro, Teresa
Ricardo, Ana Aguiar
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Araújo, Marco
Viveiros, Raquel
Correia, Tiago R.
Correia, Ilídio Joaquim Sobreira
Bonifácio, Vasco
Casimiro, Teresa
Ricardo, Ana Aguiar
dc.subject.por.fl_str_mv Melanin
PH-responsive drug release
Nanocarrier
Biocompatibility
Supercritical carbon dioxide
topic Melanin
PH-responsive drug release
Nanocarrier
Biocompatibility
Supercritical carbon dioxide
description This work proposes melanin as a new nanocarrier for pH-responsive drug release. Melanin is an abundant natural polymer that can be easily extracted from cuttlefish as nanoparticles with a suitable size range for drug delivery. However, despite its high potentiality, the application of this biopolymer in the pharmaceutical and biomedical fields is yet to be explored. Herein, melanin nanoparticles were impregnated with metronidazole, chosen as model antibiotic drug, using supercritical carbon dioxide. The drug release profile was investigated at acidic and physiologic pH, and the dominant mechanism was found to follow a non-Fickian transport. Drug release from melanin shows a strong pH dependency, which allied to its biocompatibility and lack of cytotoxicity envisages its potential application as nanocarrier in formulations for colon and intestine targeted drug delivery.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-23
2014-04-23T00:00:00Z
2018-03-20T10:32:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4648
url http://hdl.handle.net/10400.6/4648
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.ijpharm.2014.04.051
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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