Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology

Detalhes bibliográficos
Autor(a) principal: Temtem, M.
Data de Publicação: 2012
Outros Autores: Barroso, T., Casimiro, T., Mano, J. F., Aguiar Ricardo, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/25175
Resumo: biomaterials for delivery of bioactive substances that can be controlled by external stimuli. Herein we report the production of smart partially biodegradable scaffolds that exhibit pH- and temperatureresponsive behavior and their effects on the release of a model protein and a drug of low molecular weight. Chitosan (CHT) scaffolds (pH sensitive) were coated/impregnated with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), by in situ synthesis of PNIPAAm within CHT micropores. Microarchitectural analysis by scanning electron microscopy and mercury intrusion porosimetry demonstrate that the coating of the pores inner structure could be efficiently achieved without a considerable loss of porosity of native CHT-scaffolds. Two different strategies were used to impregnate the polymeric devices: supercritical fluid impregnation for scaffold uptake with a model low molecular weight drug (ibuprofen) and bulk loading to impregnate a model protein (bovine serum albumin, BSA). The release profiles showed a specific pattern according to pH and temperature. PNIPAAm temperature responsiveness is able to control BSA release but ibuprofen (Ibu) release is only mediated by pH environmental conditions.
id RCAP_54510cd828b1e516a5d67e76be365567
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/25175
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technologyBSAChitosanDrug deliveryIbuprofenPNIPAAmStimuli responsive polymersSupercritical carbon dioxideScience & Technologybiomaterials for delivery of bioactive substances that can be controlled by external stimuli. Herein we report the production of smart partially biodegradable scaffolds that exhibit pH- and temperatureresponsive behavior and their effects on the release of a model protein and a drug of low molecular weight. Chitosan (CHT) scaffolds (pH sensitive) were coated/impregnated with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), by in situ synthesis of PNIPAAm within CHT micropores. Microarchitectural analysis by scanning electron microscopy and mercury intrusion porosimetry demonstrate that the coating of the pores inner structure could be efficiently achieved without a considerable loss of porosity of native CHT-scaffolds. Two different strategies were used to impregnate the polymeric devices: supercritical fluid impregnation for scaffold uptake with a model low molecular weight drug (ibuprofen) and bulk loading to impregnate a model protein (bovine serum albumin, BSA). The release profiles showed a specific pattern according to pH and temperature. PNIPAAm temperature responsiveness is able to control BSA release but ibuprofen (Ibu) release is only mediated by pH environmental conditions.The authors would like to thank the financial support from Fundacao para a Ciencia e Tecnologia (FCT) through contracts MIT-Pt/Bs-CTRM/0051//2008, SFRH/BD/16908/2004 and SFRH/BD/62475/2009, Fundacao Calouste Gulbenkian, FEDER and FSE. We wish to thank the Analytical Services Laboratory of REQUIMTE.ElsevierUniversidade do MinhoTemtem, M.Barroso, T.Casimiro, T.Mano, J. F.Aguiar Ricardo, Ana2012-062012-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25175eng0896-844610.1016/j.supflu.2011.10.015http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=24&SID=R26mYWbF6MIAgV5us3R&page=1&doc=1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:35Zoai:repositorium.sdum.uminho.pt:1822/25175Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:14:52.139304Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
title Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
spellingShingle Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
Temtem, M.
BSA
Chitosan
Drug delivery
Ibuprofen
PNIPAAm
Stimuli responsive polymers
Supercritical carbon dioxide
Science & Technology
title_short Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
title_full Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
title_fullStr Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
title_full_unstemmed Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
title_sort Dual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
author Temtem, M.
author_facet Temtem, M.
Barroso, T.
Casimiro, T.
Mano, J. F.
Aguiar Ricardo, Ana
author_role author
author2 Barroso, T.
Casimiro, T.
Mano, J. F.
Aguiar Ricardo, Ana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Temtem, M.
Barroso, T.
Casimiro, T.
Mano, J. F.
Aguiar Ricardo, Ana
dc.subject.por.fl_str_mv BSA
Chitosan
Drug delivery
Ibuprofen
PNIPAAm
Stimuli responsive polymers
Supercritical carbon dioxide
Science & Technology
topic BSA
Chitosan
Drug delivery
Ibuprofen
PNIPAAm
Stimuli responsive polymers
Supercritical carbon dioxide
Science & Technology
description biomaterials for delivery of bioactive substances that can be controlled by external stimuli. Herein we report the production of smart partially biodegradable scaffolds that exhibit pH- and temperatureresponsive behavior and their effects on the release of a model protein and a drug of low molecular weight. Chitosan (CHT) scaffolds (pH sensitive) were coated/impregnated with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), by in situ synthesis of PNIPAAm within CHT micropores. Microarchitectural analysis by scanning electron microscopy and mercury intrusion porosimetry demonstrate that the coating of the pores inner structure could be efficiently achieved without a considerable loss of porosity of native CHT-scaffolds. Two different strategies were used to impregnate the polymeric devices: supercritical fluid impregnation for scaffold uptake with a model low molecular weight drug (ibuprofen) and bulk loading to impregnate a model protein (bovine serum albumin, BSA). The release profiles showed a specific pattern according to pH and temperature. PNIPAAm temperature responsiveness is able to control BSA release but ibuprofen (Ibu) release is only mediated by pH environmental conditions.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
2012-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/25175
url http://hdl.handle.net/1822/25175
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0896-8446
10.1016/j.supflu.2011.10.015
http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=24&SID=R26mYWbF6MIAgV5us3R&page=1&doc=1
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132592776151040

Registros relacionados