Mineral and Bone Disease (MBD) on a Kidney Transplant Patient
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/1794 |
Resumo: | A 50-year-old post-menopausal recipient of a kidney allograft with bone pain, osteoporosis, persistent hypercalcaemia and elevated parathormone (PTH) levels, despite a satisfactory graft function, was treated with bisphosphonates and cinacalcet starting, respectively, 5 and 6 months after renal transplantation (RT). Sixteen months after treatment, there was improvement of bone mineral density (BMD) measured by dualenergy X-ray absorptiometry (DEXA). A bone biopsy was taken, unveiling a surprising and worrisome result. Post-RT bone disease is different from classic CKD-MBD and should be managed distinctly, including, in some difficult cases, an invasive evaluation through the performance of a bone biopsy, as suggested in the KDIGO guidelines. |
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Mineral and Bone Disease (MBD) on a Kidney Transplant PatientDoença Mineral e Óssea (DMO) num Transplantado RenalHCC NEFBiópsiaHipercalcemiaTransplantação de RimOsteoporoseA 50-year-old post-menopausal recipient of a kidney allograft with bone pain, osteoporosis, persistent hypercalcaemia and elevated parathormone (PTH) levels, despite a satisfactory graft function, was treated with bisphosphonates and cinacalcet starting, respectively, 5 and 6 months after renal transplantation (RT). Sixteen months after treatment, there was improvement of bone mineral density (BMD) measured by dualenergy X-ray absorptiometry (DEXA). A bone biopsy was taken, unveiling a surprising and worrisome result. Post-RT bone disease is different from classic CKD-MBD and should be managed distinctly, including, in some difficult cases, an invasive evaluation through the performance of a bone biopsy, as suggested in the KDIGO guidelines.Sociedade Portuguesa de Nefrologia e HipertensãoRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEBirne, RAdragão, TFerreira, ADickson, JSilva, RCasqueiro, AOliveira, RMartins, ARTorres, JMatias, PBranco, PJorge, CWeigert, ABruges, MMachado, D2014-05-06T15:04:13Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/1794engPort J Nephrol Hypert 2014; 28(1): 69-75info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:33:23Zoai:repositorio.chlc.min-saude.pt:10400.17/1794Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:12.950374Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient Doença Mineral e Óssea (DMO) num Transplantado Renal |
title |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient |
spellingShingle |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient Birne, R HCC NEF Biópsia Hipercalcemia Transplantação de Rim Osteoporose |
title_short |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient |
title_full |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient |
title_fullStr |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient |
title_full_unstemmed |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient |
title_sort |
Mineral and Bone Disease (MBD) on a Kidney Transplant Patient |
author |
Birne, R |
author_facet |
Birne, R Adragão, T Ferreira, A Dickson, J Silva, R Casqueiro, A Oliveira, R Martins, AR Torres, J Matias, P Branco, P Jorge, C Weigert, A Bruges, M Machado, D |
author_role |
author |
author2 |
Adragão, T Ferreira, A Dickson, J Silva, R Casqueiro, A Oliveira, R Martins, AR Torres, J Matias, P Branco, P Jorge, C Weigert, A Bruges, M Machado, D |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Birne, R Adragão, T Ferreira, A Dickson, J Silva, R Casqueiro, A Oliveira, R Martins, AR Torres, J Matias, P Branco, P Jorge, C Weigert, A Bruges, M Machado, D |
dc.subject.por.fl_str_mv |
HCC NEF Biópsia Hipercalcemia Transplantação de Rim Osteoporose |
topic |
HCC NEF Biópsia Hipercalcemia Transplantação de Rim Osteoporose |
description |
A 50-year-old post-menopausal recipient of a kidney allograft with bone pain, osteoporosis, persistent hypercalcaemia and elevated parathormone (PTH) levels, despite a satisfactory graft function, was treated with bisphosphonates and cinacalcet starting, respectively, 5 and 6 months after renal transplantation (RT). Sixteen months after treatment, there was improvement of bone mineral density (BMD) measured by dualenergy X-ray absorptiometry (DEXA). A bone biopsy was taken, unveiling a surprising and worrisome result. Post-RT bone disease is different from classic CKD-MBD and should be managed distinctly, including, in some difficult cases, an invasive evaluation through the performance of a bone biopsy, as suggested in the KDIGO guidelines. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-05-06T15:04:13Z 2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/1794 |
url |
http://hdl.handle.net/10400.17/1794 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Port J Nephrol Hypert 2014; 28(1): 69-75 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia e Hipertensão |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia e Hipertensão |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131289878528000 |