Infrared spectroscopy and the characterization of terfenadine crystallized from solvents
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/7800 https://doi.org/10.1023/A:1025826329359 |
Resumo: | Abstract In this paper the structural characterization of terfenadine crystallized from ethanol-water, ethanol and methanol is performed by infrared spectroscopy. The OH stretching vibration, composed of three markedly overlapped bands, is analyzed by peak fitting. The assignment of the hydrogen bonds was conducted making use of band parameters, spectroscopic data for CCl4 solutions, and molecular dynamics calculations from dimeric systems. Terfenadine just precipitated from solvents is never in the highest crystalline state. This state is reached when the samples are heated at a temperature above 100C. Some amorphous solid is coprecipitated with the crystalline phase, particularly in methanol. |
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Infrared spectroscopy and the characterization of terfenadine crystallized from solventsAbstract In this paper the structural characterization of terfenadine crystallized from ethanol-water, ethanol and methanol is performed by infrared spectroscopy. The OH stretching vibration, composed of three markedly overlapped bands, is analyzed by peak fitting. The assignment of the hydrogen bonds was conducted making use of band parameters, spectroscopic data for CCl4 solutions, and molecular dynamics calculations from dimeric systems. Terfenadine just precipitated from solvents is never in the highest crystalline state. This state is reached when the samples are heated at a temperature above 100C. Some amorphous solid is coprecipitated with the crystalline phase, particularly in methanol.2003info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/7800http://hdl.handle.net/10316/7800https://doi.org/10.1023/A:1025826329359engJournal of Thermal Analysis and Calorimetry. 73:3 (2003) 763-774Leitão, M. L. P.Canotilho, J.Sousa, A.Pais, A.Sousa, A.Redinha, J. Simõesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-15T14:11:22Zoai:estudogeral.uc.pt:10316/7800Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:41.183340Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
title |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
spellingShingle |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents Leitão, M. L. P. |
title_short |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
title_full |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
title_fullStr |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
title_full_unstemmed |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
title_sort |
Infrared spectroscopy and the characterization of terfenadine crystallized from solvents |
author |
Leitão, M. L. P. |
author_facet |
Leitão, M. L. P. Canotilho, J. Sousa, A. Pais, A. Redinha, J. Simões |
author_role |
author |
author2 |
Canotilho, J. Sousa, A. Pais, A. Redinha, J. Simões |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Leitão, M. L. P. Canotilho, J. Sousa, A. Pais, A. Sousa, A. Redinha, J. Simões |
description |
Abstract In this paper the structural characterization of terfenadine crystallized from ethanol-water, ethanol and methanol is performed by infrared spectroscopy. The OH stretching vibration, composed of three markedly overlapped bands, is analyzed by peak fitting. The assignment of the hydrogen bonds was conducted making use of band parameters, spectroscopic data for CCl4 solutions, and molecular dynamics calculations from dimeric systems. Terfenadine just precipitated from solvents is never in the highest crystalline state. This state is reached when the samples are heated at a temperature above 100C. Some amorphous solid is coprecipitated with the crystalline phase, particularly in methanol. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/7800 http://hdl.handle.net/10316/7800 https://doi.org/10.1023/A:1025826329359 |
url |
http://hdl.handle.net/10316/7800 https://doi.org/10.1023/A:1025826329359 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Thermal Analysis and Calorimetry. 73:3 (2003) 763-774 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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