Insights on the safety of carotenogenic Chlorella vulgaris in rodents
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.9/2291 |
Resumo: | Chlorella vulgaris (Cv) biomass is widely used as a traditional food in the Orient and its safety for human consumption has been proved. However, carotenogenic biomass (orange), resulting from induced stresses, needs further safety evaluation, which is the aim of this study. The preliminary toxicological characterization of Cv consisted of a single dose (mice), repeated dose studies (mice and rats) and a biodisposition evaluation (rats). Nomortalities nor relevant clinical signs or behavioural changeswere observed inmice or in rats. The carotenoids in the rat faecal matter suggest that the carotenoids contained in Cv have been absorbed through a potentially saturated transport across the intestinalwall. No safety concerns were identified based on clinical signs, biochemical parameters, and liver and spleen histopathology. No significant differences in food/water intake, blood-pressure, blood glucose levels, glucose tolerance and plasticity of erythrocytes were observed over one month with both supplemented and control animals. The intake of carotenogenic Cv did not reveal any signs of toxicity for doses far exceeding the proposed carotenoid human-diet dose. Therefore these preliminary results suggest that the orange Cv microalgae can be used as a source of carotenoids and could be used for human consumption with possible health benefits. |
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Insights on the safety of carotenogenic Chlorella vulgaris in rodentsChlorella VulgarisSafetyBiodispositionMicroalgaCarotenoidsChlorella vulgaris (Cv) biomass is widely used as a traditional food in the Orient and its safety for human consumption has been proved. However, carotenogenic biomass (orange), resulting from induced stresses, needs further safety evaluation, which is the aim of this study. The preliminary toxicological characterization of Cv consisted of a single dose (mice), repeated dose studies (mice and rats) and a biodisposition evaluation (rats). Nomortalities nor relevant clinical signs or behavioural changeswere observed inmice or in rats. The carotenoids in the rat faecal matter suggest that the carotenoids contained in Cv have been absorbed through a potentially saturated transport across the intestinalwall. No safety concerns were identified based on clinical signs, biochemical parameters, and liver and spleen histopathology. No significant differences in food/water intake, blood-pressure, blood glucose levels, glucose tolerance and plasticity of erythrocytes were observed over one month with both supplemented and control animals. The intake of carotenogenic Cv did not reveal any signs of toxicity for doses far exceeding the proposed carotenoid human-diet dose. Therefore these preliminary results suggest that the orange Cv microalgae can be used as a source of carotenoids and could be used for human consumption with possible health benefits.ElsevierRepositório do LNEGSampayo, C.Corvo, M. L.Mendes, RogérioDuarte, D.Lucas, JoanaPinto, R.Batista, Ana PaulaRaymundo, AnabelaLima, B. SilvaBandarra, Narcisa M.Gouveia, Luisa2014-03-11T15:46:55Z2013-01-01T00:00:00Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.9/2291engSampayo, C.; Corvo, M.L.; Mendes, R.; Duarte, D.; Lucas, J.; Pinto, R.; Batistas, A.P.; Raymundo, A.; Lima, B.S.; Bandarra, N.M.; Gouveia, L. Insights on the safety of carotenogenic Chlorella vulgaris in rodents. In: Algal Research, 2013, Vol. 2, p. 409-4152211-9264info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T12:27:11Zoai:repositorio.lneg.pt:10400.9/2291Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:35:10.910180Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
title |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
spellingShingle |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents Sampayo, C. Chlorella Vulgaris Safety Biodisposition Microalga Carotenoids |
title_short |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
title_full |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
title_fullStr |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
title_full_unstemmed |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
title_sort |
Insights on the safety of carotenogenic Chlorella vulgaris in rodents |
author |
Sampayo, C. |
author_facet |
Sampayo, C. Corvo, M. L. Mendes, Rogério Duarte, D. Lucas, Joana Pinto, R. Batista, Ana Paula Raymundo, Anabela Lima, B. Silva Bandarra, Narcisa M. Gouveia, Luisa |
author_role |
author |
author2 |
Corvo, M. L. Mendes, Rogério Duarte, D. Lucas, Joana Pinto, R. Batista, Ana Paula Raymundo, Anabela Lima, B. Silva Bandarra, Narcisa M. Gouveia, Luisa |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do LNEG |
dc.contributor.author.fl_str_mv |
Sampayo, C. Corvo, M. L. Mendes, Rogério Duarte, D. Lucas, Joana Pinto, R. Batista, Ana Paula Raymundo, Anabela Lima, B. Silva Bandarra, Narcisa M. Gouveia, Luisa |
dc.subject.por.fl_str_mv |
Chlorella Vulgaris Safety Biodisposition Microalga Carotenoids |
topic |
Chlorella Vulgaris Safety Biodisposition Microalga Carotenoids |
description |
Chlorella vulgaris (Cv) biomass is widely used as a traditional food in the Orient and its safety for human consumption has been proved. However, carotenogenic biomass (orange), resulting from induced stresses, needs further safety evaluation, which is the aim of this study. The preliminary toxicological characterization of Cv consisted of a single dose (mice), repeated dose studies (mice and rats) and a biodisposition evaluation (rats). Nomortalities nor relevant clinical signs or behavioural changeswere observed inmice or in rats. The carotenoids in the rat faecal matter suggest that the carotenoids contained in Cv have been absorbed through a potentially saturated transport across the intestinalwall. No safety concerns were identified based on clinical signs, biochemical parameters, and liver and spleen histopathology. No significant differences in food/water intake, blood-pressure, blood glucose levels, glucose tolerance and plasticity of erythrocytes were observed over one month with both supplemented and control animals. The intake of carotenogenic Cv did not reveal any signs of toxicity for doses far exceeding the proposed carotenoid human-diet dose. Therefore these preliminary results suggest that the orange Cv microalgae can be used as a source of carotenoids and could be used for human consumption with possible health benefits. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01T00:00:00Z 2013-01-01T00:00:00Z 2014-03-11T15:46:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.9/2291 |
url |
http://hdl.handle.net/10400.9/2291 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sampayo, C.; Corvo, M.L.; Mendes, R.; Duarte, D.; Lucas, J.; Pinto, R.; Batistas, A.P.; Raymundo, A.; Lima, B.S.; Bandarra, N.M.; Gouveia, L. Insights on the safety of carotenogenic Chlorella vulgaris in rodents. In: Algal Research, 2013, Vol. 2, p. 409-415 2211-9264 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130216499511296 |