Melanosomes at a glance

• Autor(a) principal: Wasmeier, C.
• Data de Publicação: 2008
• Outros Autores: Hume, AN., Bolasco, G., Seabra, MC.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.7/192
• topic: RETINAL-PIGMENT EPITHELIUM; PROTEIN-KINASE-A; LYSOSOME-RELATED ORGANELLES; HERMANSKY-PUDLAK-SYNDROME; MELANOCYTE DEVELOPMENT; MELANIN TRANSFER

Melanosomes, the pigment granules that provide tissues with colour and photoprotection, are the cellular site of synthesis, storage and transport of melanin pigments. They are synthesised in mammalian skin melanocytes, in choroidal melanocytes and retinal pigment epithelial (RPE) cells in the eye, and in melanophores (a class of pigment-containing cells) in lower vertebrates. The precise fate and functions of melanosomes vary according to cell type – epidermal melanocytes supply neighbouring keratinocytes with melanosomes, which results in the pigmentation of skin and hair, whereas pigment granules are retained intracellularly in RPE cells and choroidal melanocytes. In lower vertebrates, the reversible aggregation and dispersion of melanosomes throughout the melanophore enables rapid colour change and adaptation to the environment.