Novel micro-and nanocellulose-based delivery systems for liposoluble compounds
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/35671 |
Resumo: | Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro-and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro-and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro-and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications. |
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Novel micro-and nanocellulose-based delivery systems for liposoluble compoundsCelluloseDelivery systemsLiposoluble compoundsMicrocrystalline celluloseNanocellulosePoor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro-and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro-and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro-and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications.Veritati - Repositório Institucional da Universidade Católica PortuguesaCasanova, FranciscaPereira, Carla F.Ribeiro, Alessandra B.Freixo, RicardoCosta, EduardoPintado, Manuela E.Fernandes, João C.Ramos, Óscar L.2021-10-22T12:03:04Z2021-102021-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/35671eng2079-499110.3390/nano1110259385116528799PMC854029934685034000717005500001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-12T01:34:40Zoai:repositorio.ucp.pt:10400.14/35671Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:28:58.242320Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
title |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
spellingShingle |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds Casanova, Francisca Cellulose Delivery systems Liposoluble compounds Microcrystalline cellulose Nanocellulose |
title_short |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
title_full |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
title_fullStr |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
title_full_unstemmed |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
title_sort |
Novel micro-and nanocellulose-based delivery systems for liposoluble compounds |
author |
Casanova, Francisca |
author_facet |
Casanova, Francisca Pereira, Carla F. Ribeiro, Alessandra B. Freixo, Ricardo Costa, Eduardo Pintado, Manuela E. Fernandes, João C. Ramos, Óscar L. |
author_role |
author |
author2 |
Pereira, Carla F. Ribeiro, Alessandra B. Freixo, Ricardo Costa, Eduardo Pintado, Manuela E. Fernandes, João C. Ramos, Óscar L. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Casanova, Francisca Pereira, Carla F. Ribeiro, Alessandra B. Freixo, Ricardo Costa, Eduardo Pintado, Manuela E. Fernandes, João C. Ramos, Óscar L. |
dc.subject.por.fl_str_mv |
Cellulose Delivery systems Liposoluble compounds Microcrystalline cellulose Nanocellulose |
topic |
Cellulose Delivery systems Liposoluble compounds Microcrystalline cellulose Nanocellulose |
description |
Poor aqueous solubility of bioactive compounds is becoming a pronounced challenge in the development of bioactive formulations. Numerous liposoluble compounds have very interesting biological activities, but their low water solubility, stability, and bioavailability restrict their applications. To overcome these limitations there is a need to use enabling delivering strategies, which often demand new carrier materials. Cellulose and its micro-and nanostructures are promising carriers with unique features. In this context, this review describes the fast-growing field of micro-and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems. Although there are promising perspectives for introducing these materials into various fields, aspects of safety and toxicity must be revealed and are discussed in this review. The impact of gastrointestinal conditions on the systems and on the bioavailability of the bioactive compounds are also addressed in this review. This article helps to unveil the whole panorama of micro-and nanocellulose as delivery systems for liposoluble compounds, showing that these represent a great promise in a wide range of applications. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-22T12:03:04Z 2021-10 2021-10-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/35671 |
url |
http://hdl.handle.net/10400.14/35671 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2079-4991 10.3390/nano11102593 85116528799 PMC8540299 34685034 000717005500001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132009622142976 |