POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy

Detalhes bibliográficos
Autor(a) principal: Restani, Rita B.
Data de Publicação: 2018
Outros Autores: Pires, Rita F., Tolmatcheva, Anna, Cabral, Rita, Baptista, Pedro V., Fernandes, Alexandra R., Casimiro, Teresa, Bonifácio, Vasco D. B., Aguiar-Ricardo, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1002/open.201800093
Resumo: This work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.
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spelling POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapychemotherapycomposite particlesdendrimersdrug deliverypulmonary deliveryChemistry(all)This work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.LAQV@REQUIMTEDQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNRestani, Rita B.Pires, Rita F.Tolmatcheva, AnnaCabral, RitaBaptista, Pedro V.Fernandes, Alexandra R.Casimiro, TeresaBonifácio, Vasco D. B.Aguiar-Ricardo, Ana2019-01-29T23:46:00Z2018-10-012018-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttps://doi.org/10.1002/open.201800093eng2191-1363PURE: 6194931http://www.scopus.com/inward/record.url?scp=85055532518&partnerID=8YFLogxKhttps://doi.org/10.1002/open.201800093info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:28:22Zoai:run.unl.pt:10362/59006Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:33:19.478137Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
title POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
spellingShingle POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
Restani, Rita B.
chemotherapy
composite particles
dendrimers
drug delivery
pulmonary delivery
Chemistry(all)
title_short POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
title_full POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
title_fullStr POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
title_full_unstemmed POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
title_sort POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy
author Restani, Rita B.
author_facet Restani, Rita B.
Pires, Rita F.
Tolmatcheva, Anna
Cabral, Rita
Baptista, Pedro V.
Fernandes, Alexandra R.
Casimiro, Teresa
Bonifácio, Vasco D. B.
Aguiar-Ricardo, Ana
author_role author
author2 Pires, Rita F.
Tolmatcheva, Anna
Cabral, Rita
Baptista, Pedro V.
Fernandes, Alexandra R.
Casimiro, Teresa
Bonifácio, Vasco D. B.
Aguiar-Ricardo, Ana
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Restani, Rita B.
Pires, Rita F.
Tolmatcheva, Anna
Cabral, Rita
Baptista, Pedro V.
Fernandes, Alexandra R.
Casimiro, Teresa
Bonifácio, Vasco D. B.
Aguiar-Ricardo, Ana
dc.subject.por.fl_str_mv chemotherapy
composite particles
dendrimers
drug delivery
pulmonary delivery
Chemistry(all)
topic chemotherapy
composite particles
dendrimers
drug delivery
pulmonary delivery
Chemistry(all)
description This work was supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UID/QUI/50006/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER -007265), the Unidade de Cithornncias Biomoleculares Aplicadas UCIBIO-REQUIMTE, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728). The authors acknowledge the Ph.D. grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/109006/2015 (R.F.P.). T.C. also acknowledges FCT-Lisbon for the IF/00915/2014 contract.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-01
2018-10-01T00:00:00Z
2019-01-29T23:46:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1002/open.201800093
url https://doi.org/10.1002/open.201800093
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2191-1363
PURE: 6194931
http://www.scopus.com/inward/record.url?scp=85055532518&partnerID=8YFLogxK
https://doi.org/10.1002/open.201800093
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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