HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic"
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/41079 |
Resumo: | Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases the risk of developing tuberculosis (TB) by a factor of 20 in latently infected people, and even patients with controlled HIV infection on antiretroviral therapy (ART) have a fourfold increased risk of developing TB. Conversely, Mtb infection exacerbates HIV pathogenesis and increases the rate of AIDS progression. In this review, we discuss this reciprocal amplification of HIV/Mtb coinfection and how they influence each other's pathogenesis. Elucidating the infectious cofactors that impact on pathogenesis may open doors for the design of new potential therapeutic strategies to control disease progression, especially in contexts where vaccines or the sterile clearance of pathogens are not effectively available. |
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HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic"TuberculosisHIVGranulomaImmunodeficiencyCo-infectionHuman immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases the risk of developing tuberculosis (TB) by a factor of 20 in latently infected people, and even patients with controlled HIV infection on antiretroviral therapy (ART) have a fourfold increased risk of developing TB. Conversely, Mtb infection exacerbates HIV pathogenesis and increases the rate of AIDS progression. In this review, we discuss this reciprocal amplification of HIV/Mtb coinfection and how they influence each other's pathogenesis. Elucidating the infectious cofactors that impact on pathogenesis may open doors for the design of new potential therapeutic strategies to control disease progression, especially in contexts where vaccines or the sterile clearance of pathogens are not effectively available.Veritati - Repositório Institucional da Universidade Católica PortuguesaAzevedo-Pereira, José MiguelPires, DavidCalado, MartaMandal, ManojSantos-Costa, QuirinaAnes, Elsa2023-05-10T10:39:17Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/41079eng2076-260710.3390/microorganisms1104085385153782296PMC1014219537110276000978050200001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:46:40Zoai:repositorio.ucp.pt:10400.14/41079Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:33:45.618749Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
title |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
spellingShingle |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" Azevedo-Pereira, José Miguel Tuberculosis HIV Granuloma Immunodeficiency Co-infection |
title_short |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
title_full |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
title_fullStr |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
title_full_unstemmed |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
title_sort |
HIV/Mtb co-infection: from the amplification of disease pathogenesis to an "emerging syndemic" |
author |
Azevedo-Pereira, José Miguel |
author_facet |
Azevedo-Pereira, José Miguel Pires, David Calado, Marta Mandal, Manoj Santos-Costa, Quirina Anes, Elsa |
author_role |
author |
author2 |
Pires, David Calado, Marta Mandal, Manoj Santos-Costa, Quirina Anes, Elsa |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Azevedo-Pereira, José Miguel Pires, David Calado, Marta Mandal, Manoj Santos-Costa, Quirina Anes, Elsa |
dc.subject.por.fl_str_mv |
Tuberculosis HIV Granuloma Immunodeficiency Co-infection |
topic |
Tuberculosis HIV Granuloma Immunodeficiency Co-infection |
description |
Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases the risk of developing tuberculosis (TB) by a factor of 20 in latently infected people, and even patients with controlled HIV infection on antiretroviral therapy (ART) have a fourfold increased risk of developing TB. Conversely, Mtb infection exacerbates HIV pathogenesis and increases the rate of AIDS progression. In this review, we discuss this reciprocal amplification of HIV/Mtb coinfection and how they influence each other's pathogenesis. Elucidating the infectious cofactors that impact on pathogenesis may open doors for the design of new potential therapeutic strategies to control disease progression, especially in contexts where vaccines or the sterile clearance of pathogens are not effectively available. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-10T10:39:17Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/41079 |
url |
http://hdl.handle.net/10400.14/41079 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2076-2607 10.3390/microorganisms11040853 85153782296 PMC10142195 37110276 000978050200001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132064377733120 |