HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/59012 |
Resumo: | Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases the risk of developing tuberculosis (TB) by a factor of 20 in latently infected people, and even patients with controlled HIV infection on antiretroviral therapy (ART) have a fourfold increased risk of developing TB. Conversely, Mtb infection exacerbates HIV pathogenesis and increases the rate of AIDS progression. In this review, we discuss this reciprocal amplification of HIV/Mtb coinfection and how they influence each other’s pathogenesis. Elucidating the infectious cofactors that impact on pathogenesis may open doors for the design of new potential therapeutic strategies to control disease progression, especially in contexts where vaccines or the sterile clearance of pathogens are not effectively available. |
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HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging SyndemictuberculosisHIVgranulomaimmunodeficiencyco-infectionHuman immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases the risk of developing tuberculosis (TB) by a factor of 20 in latently infected people, and even patients with controlled HIV infection on antiretroviral therapy (ART) have a fourfold increased risk of developing TB. Conversely, Mtb infection exacerbates HIV pathogenesis and increases the rate of AIDS progression. In this review, we discuss this reciprocal amplification of HIV/Mtb coinfection and how they influence each other’s pathogenesis. Elucidating the infectious cofactors that impact on pathogenesis may open doors for the design of new potential therapeutic strategies to control disease progression, especially in contexts where vaccines or the sterile clearance of pathogens are not effectively available.The research linked to this work was funded by Fundação para a Ciência e a Tecnologia (FCT)—grant numbers PTDC/SAU-INF/28182/2017 to E.A., EXPL/SAU-INF/0742/2021 to D.P., and UIDB/04138/2020 to IMed-ULisboa. It was also funded by Gilead Sciences Portugal (Gilead Génese Programme 2019) to J.M.A.-P.; M.C. is supported by a PhD fellowship from FCT with the reference SFRH/BD/131948/2017; M.M. is supported by a PhD fellowship from FCT with the reference 2021.07978.BD.MDPIRepositório da Universidade de LisboaAzevedo-Pereira, José MiguelPires, DavidCalado, MartaMandal, ManojSantos-Costa, QuirinaAnes, Elsa2023-08-24T17:59:52Z2023-03-272023-06-02T16:28:54Z2023-03-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59012engAzevedo-Pereira JM, Pires D, Calado M, Mandal M, Santos-Costa Q, Anes E. HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an “Emerging Syndemic.” Microorganisms [Internet]. 2023 Mar 27;11(4):853. Available from: http://dx.doi.org/10.3390/microorganisms110408532076-2607cv-prod-319558110.3390/microorganisms11040853info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:40Zoai:repositorio.ul.pt:10451/59012Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:20.265820Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
title |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
spellingShingle |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic Azevedo-Pereira, José Miguel tuberculosis HIV granuloma immunodeficiency co-infection |
title_short |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
title_full |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
title_fullStr |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
title_full_unstemmed |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
title_sort |
HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an Emerging Syndemic |
author |
Azevedo-Pereira, José Miguel |
author_facet |
Azevedo-Pereira, José Miguel Pires, David Calado, Marta Mandal, Manoj Santos-Costa, Quirina Anes, Elsa |
author_role |
author |
author2 |
Pires, David Calado, Marta Mandal, Manoj Santos-Costa, Quirina Anes, Elsa |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Azevedo-Pereira, José Miguel Pires, David Calado, Marta Mandal, Manoj Santos-Costa, Quirina Anes, Elsa |
dc.subject.por.fl_str_mv |
tuberculosis HIV granuloma immunodeficiency co-infection |
topic |
tuberculosis HIV granuloma immunodeficiency co-infection |
description |
Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases the risk of developing tuberculosis (TB) by a factor of 20 in latently infected people, and even patients with controlled HIV infection on antiretroviral therapy (ART) have a fourfold increased risk of developing TB. Conversely, Mtb infection exacerbates HIV pathogenesis and increases the rate of AIDS progression. In this review, we discuss this reciprocal amplification of HIV/Mtb coinfection and how they influence each other’s pathogenesis. Elucidating the infectious cofactors that impact on pathogenesis may open doors for the design of new potential therapeutic strategies to control disease progression, especially in contexts where vaccines or the sterile clearance of pathogens are not effectively available. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-24T17:59:52Z 2023-03-27 2023-06-02T16:28:54Z 2023-03-27T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/59012 |
url |
http://hdl.handle.net/10451/59012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Azevedo-Pereira JM, Pires D, Calado M, Mandal M, Santos-Costa Q, Anes E. HIV/Mtb Co-Infection: From the Amplification of Disease Pathogenesis to an “Emerging Syndemic.” Microorganisms [Internet]. 2023 Mar 27;11(4):853. Available from: http://dx.doi.org/10.3390/microorganisms11040853 2076-2607 cv-prod-3195581 10.3390/microorganisms11040853 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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