Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/120501 |
Resumo: | Over the last decades, many naturally occurring peptides have attracted the attention of medicinal chemists due to their promising applicability as pharmaceuticals or as models for drugs used in therapeutics. Marine peptides are chiral molecules comprising different amino acid residues. Therefore, it is essential to establish the configuration of the stereogenic carbon of their amino acid constituents for a total characterization and further synthesis to obtain higher amount of the bioactive marine peptides or as a basis for structural modifications for more potent derivatives. Moreover, it is also a crucial issue taking into account the mechanisms of molecular recognition and the influence of molecular three-dimensionality in this process. In this review, a literature survey covering the report on the determination of absolute configuration of the amino acid residues of diverse marine peptides by chromatographic methodologies is presented. A brief summary of their biological activities was also included emphasizing to the most promising marine peptides. A case study describing an experience of our group was also included. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
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Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivitiespeptidechemistryliquid chromatographyproceduresprotein secondary structuresynthesisChromatography, LiquidPeptidesProtein Structure, SecondaryOver the last decades, many naturally occurring peptides have attracted the attention of medicinal chemists due to their promising applicability as pharmaceuticals or as models for drugs used in therapeutics. Marine peptides are chiral molecules comprising different amino acid residues. Therefore, it is essential to establish the configuration of the stereogenic carbon of their amino acid constituents for a total characterization and further synthesis to obtain higher amount of the bioactive marine peptides or as a basis for structural modifications for more potent derivatives. Moreover, it is also a crucial issue taking into account the mechanisms of molecular recognition and the influence of molecular three-dimensionality in this process. In this review, a literature survey covering the report on the determination of absolute configuration of the amino acid residues of diverse marine peptides by chromatographic methodologies is presented. A brief summary of their biological activities was also included emphasizing to the most promising marine peptides. A case study describing an experience of our group was also included. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.MDPI20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/120501eng1420304910.3390/molecules23020306Phyo Y.Ribeiro J.Fernandes C.Kijjoa A.Pinto M.M.M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:51:34Zoai:repositorio-aberto.up.pt:10216/120501Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:33:54.810507Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
title |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
spellingShingle |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities Phyo Y. peptide chemistry liquid chromatography procedures protein secondary structure synthesis Chromatography, Liquid Peptides Protein Structure, Secondary |
title_short |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
title_full |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
title_fullStr |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
title_full_unstemmed |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
title_sort |
Marine natural peptides: Determination of absolute configuration using liquid chromatography methods and evaluation of bioactivities |
author |
Phyo Y. |
author_facet |
Phyo Y. Ribeiro J. Fernandes C. Kijjoa A. Pinto M.M.M. |
author_role |
author |
author2 |
Ribeiro J. Fernandes C. Kijjoa A. Pinto M.M.M. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Phyo Y. Ribeiro J. Fernandes C. Kijjoa A. Pinto M.M.M. |
dc.subject.por.fl_str_mv |
peptide chemistry liquid chromatography procedures protein secondary structure synthesis Chromatography, Liquid Peptides Protein Structure, Secondary |
topic |
peptide chemistry liquid chromatography procedures protein secondary structure synthesis Chromatography, Liquid Peptides Protein Structure, Secondary |
description |
Over the last decades, many naturally occurring peptides have attracted the attention of medicinal chemists due to their promising applicability as pharmaceuticals or as models for drugs used in therapeutics. Marine peptides are chiral molecules comprising different amino acid residues. Therefore, it is essential to establish the configuration of the stereogenic carbon of their amino acid constituents for a total characterization and further synthesis to obtain higher amount of the bioactive marine peptides or as a basis for structural modifications for more potent derivatives. Moreover, it is also a crucial issue taking into account the mechanisms of molecular recognition and the influence of molecular three-dimensionality in this process. In this review, a literature survey covering the report on the determination of absolute configuration of the amino acid residues of diverse marine peptides by chromatographic methodologies is presented. A brief summary of their biological activities was also included emphasizing to the most promising marine peptides. A case study describing an experience of our group was also included. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/120501 |
url |
https://hdl.handle.net/10216/120501 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
14203049 10.3390/molecules23020306 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136248183390208 |