Reactive oxygen species, ageing and the hormesis police
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/25191 |
Resumo: | For more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis. |
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Reactive oxygen species, ageing and the hormesis policeHormesisROS signallingOxidative damageCaloric restrictionLongevityAgeingScience & TechnologyFor more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis.The authors wish to thank Molly Burhans for preparing the figures. This work was supported by Fundacao para a Ciencia e Tecnologia (FCT) and COMPETE/QREN/EU (PTDC/BIA-MIC/114116/2009), a grant from the Roswell Park Alliance Foundation and by a National Cancer Institute Support Grant (P30CA016056) to Roswell Park Cancer Institute. Authors have no conflict of interest to declare.WileyUniversidade do MinhoLudovico, PaulaBurhans, William C.20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25191eng1567-135610.1111/1567-1364.1207023965186http://onlinelibrary.wiley.com/doi/10.1111/1567-1364.12070/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:50:20Zoai:repositorium.sdum.uminho.pt:1822/25191Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:00.089293Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Reactive oxygen species, ageing and the hormesis police |
title |
Reactive oxygen species, ageing and the hormesis police |
spellingShingle |
Reactive oxygen species, ageing and the hormesis police Ludovico, Paula Hormesis ROS signalling Oxidative damage Caloric restriction Longevity Ageing Science & Technology |
title_short |
Reactive oxygen species, ageing and the hormesis police |
title_full |
Reactive oxygen species, ageing and the hormesis police |
title_fullStr |
Reactive oxygen species, ageing and the hormesis police |
title_full_unstemmed |
Reactive oxygen species, ageing and the hormesis police |
title_sort |
Reactive oxygen species, ageing and the hormesis police |
author |
Ludovico, Paula |
author_facet |
Ludovico, Paula Burhans, William C. |
author_role |
author |
author2 |
Burhans, William C. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ludovico, Paula Burhans, William C. |
dc.subject.por.fl_str_mv |
Hormesis ROS signalling Oxidative damage Caloric restriction Longevity Ageing Science & Technology |
topic |
Hormesis ROS signalling Oxidative damage Caloric restriction Longevity Ageing Science & Technology |
description |
For more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/25191 |
url |
http://hdl.handle.net/1822/25191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1567-1356 10.1111/1567-1364.12070 23965186 http://onlinelibrary.wiley.com/doi/10.1111/1567-1364.12070/full |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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