Reactive oxygen species, ageing and the hormesis police

Detalhes bibliográficos
Autor(a) principal: Ludovico, Paula
Data de Publicação: 2014
Outros Autores: Burhans, William C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/25191
Resumo: For more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis.
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spelling Reactive oxygen species, ageing and the hormesis policeHormesisROS signallingOxidative damageCaloric restrictionLongevityAgeingScience & TechnologyFor more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis.The authors wish to thank Molly Burhans for preparing the figures. This work was supported by Fundacao para a Ciencia e Tecnologia (FCT) and COMPETE/QREN/EU (PTDC/BIA-MIC/114116/2009), a grant from the Roswell Park Alliance Foundation and by a National Cancer Institute Support Grant (P30CA016056) to Roswell Park Cancer Institute. Authors have no conflict of interest to declare.WileyUniversidade do MinhoLudovico, PaulaBurhans, William C.20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25191eng1567-135610.1111/1567-1364.1207023965186http://onlinelibrary.wiley.com/doi/10.1111/1567-1364.12070/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:50:20Zoai:repositorium.sdum.uminho.pt:1822/25191Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:00.089293Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Reactive oxygen species, ageing and the hormesis police
title Reactive oxygen species, ageing and the hormesis police
spellingShingle Reactive oxygen species, ageing and the hormesis police
Ludovico, Paula
Hormesis
ROS signalling
Oxidative damage
Caloric restriction
Longevity
Ageing
Science & Technology
title_short Reactive oxygen species, ageing and the hormesis police
title_full Reactive oxygen species, ageing and the hormesis police
title_fullStr Reactive oxygen species, ageing and the hormesis police
title_full_unstemmed Reactive oxygen species, ageing and the hormesis police
title_sort Reactive oxygen species, ageing and the hormesis police
author Ludovico, Paula
author_facet Ludovico, Paula
Burhans, William C.
author_role author
author2 Burhans, William C.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ludovico, Paula
Burhans, William C.
dc.subject.por.fl_str_mv Hormesis
ROS signalling
Oxidative damage
Caloric restriction
Longevity
Ageing
Science & Technology
topic Hormesis
ROS signalling
Oxidative damage
Caloric restriction
Longevity
Ageing
Science & Technology
description For more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/25191
url http://hdl.handle.net/1822/25191
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1567-1356
10.1111/1567-1364.12070
23965186
http://onlinelibrary.wiley.com/doi/10.1111/1567-1364.12070/full
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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