Does cotinine act upon reactive oxygen species and peroxidases?

Detalhes bibliográficos
Autor(a) principal: Vellosa,J.C.R.
Data de Publicação: 2007
Outros Autores: Khalil,N.M., Fonseca,L.M., Brunetti,I.L., Oliveira,O.M.M.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Eclética Química
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702007000100009
Resumo: Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.
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spelling Does cotinine act upon reactive oxygen species and peroxidases?nicotinecotininemyeloperoxidaseROSoxidative damageNicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702007000100009Eclética Química v.32 n.1 2007reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702007000100009info:eu-repo/semantics/openAccessVellosa,J.C.R.Khalil,N.M.Fonseca,L.M.Brunetti,I.L.Oliveira,O.M.M.F.eng2007-06-04T00:00:00Zoai:scielo:S0100-46702007000100009Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2007-06-04T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv Does cotinine act upon reactive oxygen species and peroxidases?
title Does cotinine act upon reactive oxygen species and peroxidases?
spellingShingle Does cotinine act upon reactive oxygen species and peroxidases?
Vellosa,J.C.R.
nicotine
cotinine
myeloperoxidase
ROS
oxidative damage
title_short Does cotinine act upon reactive oxygen species and peroxidases?
title_full Does cotinine act upon reactive oxygen species and peroxidases?
title_fullStr Does cotinine act upon reactive oxygen species and peroxidases?
title_full_unstemmed Does cotinine act upon reactive oxygen species and peroxidases?
title_sort Does cotinine act upon reactive oxygen species and peroxidases?
author Vellosa,J.C.R.
author_facet Vellosa,J.C.R.
Khalil,N.M.
Fonseca,L.M.
Brunetti,I.L.
Oliveira,O.M.M.F.
author_role author
author2 Khalil,N.M.
Fonseca,L.M.
Brunetti,I.L.
Oliveira,O.M.M.F.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vellosa,J.C.R.
Khalil,N.M.
Fonseca,L.M.
Brunetti,I.L.
Oliveira,O.M.M.F.
dc.subject.por.fl_str_mv nicotine
cotinine
myeloperoxidase
ROS
oxidative damage
topic nicotine
cotinine
myeloperoxidase
ROS
oxidative damage
description Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702007000100009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702007000100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702007000100009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.32 n.1 2007
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
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