Does cotinine act upon reactive oxygen species and peroxidases?

Detalhes bibliográficos
Autor(a) principal: Vellosa, J. C R [UNESP]
Data de Publicação: 2007
Outros Autores: Khalil, N. M. [UNESP], Fonseca, L. M. [UNESP], Brunetti, Iguatemy Lourenço [UNESP], Oliveira, Olga Maria Mascarenhas de Faria [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-46702007000100009
http://hdl.handle.net/11449/69721
Resumo: Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H 2O 2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.
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spelling Does cotinine act upon reactive oxygen species and peroxidases?CotinineMyeloperoxidaseNicotineOxidative damageROSNicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H 2O 2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.UNESP - Sao Paulo State University Biochemistry and Technological Chemistry Department Chemistry Institute, Araraquara-SPUNESP - Sao Paulo State University Clinical Analysis Department School of Pharmaceutical Sciences, Araraquara-SPUNESP - Sao Paulo State University Biochemistry and Technological Chemistry Department Chemistry Institute, Araraquara-SPUNESP - Sao Paulo State University Clinical Analysis Department School of Pharmaceutical Sciences, Araraquara-SPUniversidade Estadual Paulista (Unesp)Vellosa, J. C R [UNESP]Khalil, N. M. [UNESP]Fonseca, L. M. [UNESP]Brunetti, Iguatemy Lourenço [UNESP]Oliveira, Olga Maria Mascarenhas de Faria [UNESP]2014-05-27T11:22:30Z2014-05-27T11:22:30Z2007-06-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article65-70application/pdfhttp://dx.doi.org/10.1590/S0100-46702007000100009Ecletica Quimica, v. 32, n. 1, p. 65-70, 2007.0100-4670http://hdl.handle.net/11449/6972110.1590/S0100-46702007000100009S0100-467020070001000092-s2.0-342503350242-s2.0-34250335024.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEclética Químicainfo:eu-repo/semantics/openAccess2024-06-21T15:18:16Zoai:repositorio.unesp.br:11449/69721Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:19:36.624692Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Does cotinine act upon reactive oxygen species and peroxidases?
title Does cotinine act upon reactive oxygen species and peroxidases?
spellingShingle Does cotinine act upon reactive oxygen species and peroxidases?
Vellosa, J. C R [UNESP]
Cotinine
Myeloperoxidase
Nicotine
Oxidative damage
ROS
title_short Does cotinine act upon reactive oxygen species and peroxidases?
title_full Does cotinine act upon reactive oxygen species and peroxidases?
title_fullStr Does cotinine act upon reactive oxygen species and peroxidases?
title_full_unstemmed Does cotinine act upon reactive oxygen species and peroxidases?
title_sort Does cotinine act upon reactive oxygen species and peroxidases?
author Vellosa, J. C R [UNESP]
author_facet Vellosa, J. C R [UNESP]
Khalil, N. M. [UNESP]
Fonseca, L. M. [UNESP]
Brunetti, Iguatemy Lourenço [UNESP]
Oliveira, Olga Maria Mascarenhas de Faria [UNESP]
author_role author
author2 Khalil, N. M. [UNESP]
Fonseca, L. M. [UNESP]
Brunetti, Iguatemy Lourenço [UNESP]
Oliveira, Olga Maria Mascarenhas de Faria [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Vellosa, J. C R [UNESP]
Khalil, N. M. [UNESP]
Fonseca, L. M. [UNESP]
Brunetti, Iguatemy Lourenço [UNESP]
Oliveira, Olga Maria Mascarenhas de Faria [UNESP]
dc.subject.por.fl_str_mv Cotinine
Myeloperoxidase
Nicotine
Oxidative damage
ROS
topic Cotinine
Myeloperoxidase
Nicotine
Oxidative damage
ROS
description Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H 2O 2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-19
2014-05-27T11:22:30Z
2014-05-27T11:22:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-46702007000100009
Ecletica Quimica, v. 32, n. 1, p. 65-70, 2007.
0100-4670
http://hdl.handle.net/11449/69721
10.1590/S0100-46702007000100009
S0100-46702007000100009
2-s2.0-34250335024
2-s2.0-34250335024.pdf
url http://dx.doi.org/10.1590/S0100-46702007000100009
http://hdl.handle.net/11449/69721
identifier_str_mv Ecletica Quimica, v. 32, n. 1, p. 65-70, 2007.
0100-4670
10.1590/S0100-46702007000100009
S0100-46702007000100009
2-s2.0-34250335024
2-s2.0-34250335024.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eclética Química
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 65-70
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128219164966912

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