Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/11110/532 |
Resumo: | Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions. |
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Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarizationAmygdalaLocal Field PotentialsAnxietypre-frontal cortexstressventral hippocampusExposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.Luis R. Jacinto was supported by the Portuguese Foundation for Science and Technology (FCT) under grant SFRH/BD/40459/2007. This work was supported by FCT and FEDER funds through Programa Operacional Factores de Competitividade (COMPETE) with project references FCOMP- 01-0124-FEDER-021145 (FCT/PTDC/SAU-ENB/118383/2010) and FCOMP-01-0124-FEDER-022674; ADI Project “DoIT— Desenvolvimento e Operacionalização da Investigação de Translação” (“MyHealth-PPS4”; project n◦ 13853); and a BIAL Foundation Grant (138/2008 to João J. Cerqueira).Frontiers in Behavioral Neuroscience2013-12-21T14:06:35Z2013-12-21T14:06:35Z2013-10-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/11110/532oai:ciencipca.ipca.pt:11110/532engDOI: 10.3389/fnbeh.2013.00127http://hdl.handle.net/11110/532Jacinto, LuísReis, JoanaDias, Nuno S.Cerqueira, João J.Correia, José HiginoSousa, Nunoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T12:52:05Zoai:ciencipca.ipca.pt:11110/532Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:00:57.388132Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
spellingShingle |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization Jacinto, Luís Amygdala Local Field Potentials Anxiety pre-frontal cortex stress ventral hippocampus |
title_short |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_full |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_fullStr |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_full_unstemmed |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
title_sort |
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization |
author |
Jacinto, Luís |
author_facet |
Jacinto, Luís Reis, Joana Dias, Nuno S. Cerqueira, João J. Correia, José Higino Sousa, Nuno |
author_role |
author |
author2 |
Reis, Joana Dias, Nuno S. Cerqueira, João J. Correia, José Higino Sousa, Nuno |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Jacinto, Luís Reis, Joana Dias, Nuno S. Cerqueira, João J. Correia, José Higino Sousa, Nuno |
dc.subject.por.fl_str_mv |
Amygdala Local Field Potentials Anxiety pre-frontal cortex stress ventral hippocampus |
topic |
Amygdala Local Field Potentials Anxiety pre-frontal cortex stress ventral hippocampus |
description |
Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-21T14:06:35Z 2013-12-21T14:06:35Z 2013-10-14T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/11110/532 oai:ciencipca.ipca.pt:11110/532 |
url |
http://hdl.handle.net/11110/532 |
identifier_str_mv |
oai:ciencipca.ipca.pt:11110/532 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
DOI: 10.3389/fnbeh.2013.00127 http://hdl.handle.net/11110/532 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers in Behavioral Neuroscience |
publisher.none.fl_str_mv |
Frontiers in Behavioral Neuroscience |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799129879860477952 |