Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25918 https://doi.org/10.1002/hipo.23021 |
Resumo: | Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus‐like perception in animal models. Here we assess whether salicylate induces anxiety‐like electrophysiological and behavioural signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hour after salicylate (300mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate‐treated animals showed a strong 4‐6Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4‐6Hz‐theta band was low in the ventral and dorsal hippocampus when compared to movement‐related theta coherence (7‐10Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate‐induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety‐like behaviours. Here we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association. |
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Winne, JessicaFranzon, RafaelMiranda, AronMalfatti, ThawannPatriota, JoãoMikulovic, SanjaLeão, Emelie Katarina SvahnLeão, Richardson Naves2018-09-28T16:24:28Z2018-09-28T16:24:28Z2018-08-28Winne J, Franzon R, Miranda A, Malfatti T, Patriota J, Mikulovic S, Leão KE, Leão RN. Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency. Hippocampus. 2018 Aug 28. doi: 10.1002/hipo.23021. [Epub ahead of print]https://repositorio.ufrn.br/jspui/handle/123456789/25918https://doi.org/10.1002/hipo.23021engSalicylateanxietythetatinnitusventral hippocampusSalicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequencyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSalicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus‐like perception in animal models. Here we assess whether salicylate induces anxiety‐like electrophysiological and behavioural signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hour after salicylate (300mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate‐treated animals showed a strong 4‐6Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4‐6Hz‐theta band was low in the ventral and dorsal hippocampus when compared to movement‐related theta coherence (7‐10Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate‐induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety‐like behaviours. Here we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25918/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.txtRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.txtExtracted texttext/plain50027https://repositorio.ufrn.br/bitstream/123456789/25918/3/RichardsonLeao_ICe_2018_Salicylate%20induces%20anxiety-like.pdf.txtb6368efbcc7932c215d1b1e82022c5e9MD53THUMBNAILRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.jpgRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.jpgIM Thumbnailimage/jpeg5148https://repositorio.ufrn.br/bitstream/123456789/25918/4/RichardsonLeao_ICe_2018_Salicylate%20induces%20anxiety-like.pdf.jpg10e6f6a0d42b4993933a5ba6c1abd5adMD54TEXTRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.txtRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.txtExtracted texttext/plain50027https://repositorio.ufrn.br/bitstream/123456789/25918/3/RichardsonLeao_ICe_2018_Salicylate%20induces%20anxiety-like.pdf.txtb6368efbcc7932c215d1b1e82022c5e9MD53THUMBNAILRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.jpgRichardsonLeao_ICe_2018_Salicylate induces anxiety-like.pdf.jpgIM Thumbnailimage/jpeg5148https://repositorio.ufrn.br/bitstream/123456789/25918/4/RichardsonLeao_ICe_2018_Salicylate%20induces%20anxiety-like.pdf.jpg10e6f6a0d42b4993933a5ba6c1abd5adMD54123456789/259182022-10-18 18:21:47.43oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-10-18T21:21:47Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
title |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
spellingShingle |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency Winne, Jessica Salicylate anxiety theta tinnitus ventral hippocampus |
title_short |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
title_full |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
title_fullStr |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
title_full_unstemmed |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
title_sort |
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency |
author |
Winne, Jessica |
author_facet |
Winne, Jessica Franzon, Rafael Miranda, Aron Malfatti, Thawann Patriota, João Mikulovic, Sanja Leão, Emelie Katarina Svahn Leão, Richardson Naves |
author_role |
author |
author2 |
Franzon, Rafael Miranda, Aron Malfatti, Thawann Patriota, João Mikulovic, Sanja Leão, Emelie Katarina Svahn Leão, Richardson Naves |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Winne, Jessica Franzon, Rafael Miranda, Aron Malfatti, Thawann Patriota, João Mikulovic, Sanja Leão, Emelie Katarina Svahn Leão, Richardson Naves |
dc.subject.por.fl_str_mv |
Salicylate anxiety theta tinnitus ventral hippocampus |
topic |
Salicylate anxiety theta tinnitus ventral hippocampus |
description |
Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus‐like perception in animal models. Here we assess whether salicylate induces anxiety‐like electrophysiological and behavioural signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hour after salicylate (300mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate‐treated animals showed a strong 4‐6Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4‐6Hz‐theta band was low in the ventral and dorsal hippocampus when compared to movement‐related theta coherence (7‐10Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate‐induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety‐like behaviours. Here we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-09-28T16:24:28Z |
dc.date.available.fl_str_mv |
2018-09-28T16:24:28Z |
dc.date.issued.fl_str_mv |
2018-08-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Winne J, Franzon R, Miranda A, Malfatti T, Patriota J, Mikulovic S, Leão KE, Leão RN. Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency. Hippocampus. 2018 Aug 28. doi: 10.1002/hipo.23021. [Epub ahead of print] |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/25918 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1002/hipo.23021 |
identifier_str_mv |
Winne J, Franzon R, Miranda A, Malfatti T, Patriota J, Mikulovic S, Leão KE, Leão RN. Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency. Hippocampus. 2018 Aug 28. doi: 10.1002/hipo.23021. [Epub ahead of print] |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/25918 https://doi.org/10.1002/hipo.23021 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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