Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2697 |
Resumo: | PURPOSE: To determine the risk of second primary neoplasms (SPNs) in subjects previously diagnosed with uveal melanoma (UM), including an analysis on whether radiotherapy is a risk factor to develop these SPNs. DESIGN: Retrospective cohort study. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) 9 database, we identified patients diagnosed with UM as their first malignancy between 1973 and 2011 (n = 3976). We obtained standardized incidence ratios (SIR) and excess absolute risks of SPNs on patients with UM compared to a reference population. Multivariate Cox regression models were used to evaluate the effect of radiotherapy in SPN risk. RESULTS: Sixteen percent (n = 641) of the patients developed SPNs during a median follow-up of 83 months (range, 1-463 months). This represented an 11% excess risk compared to the reference population, mainly owing to a significantly increased risk of skin melanomas (SIR = 2.93, 95% CI: 2.23-3.78) and kidney tumors (SIR = 1.91, 95% CI: 1.27-2.76), primarily in those diagnosed between 30 and 59 years of age. The occurrence of second UM was also increased (SIR = 16.90, 95% CI: 9.00-28.90), which likely includes recurrences misclassified as a second cancer. Radiotherapy was performed in 39% (n = 1538) of the patients. Multivariate analysis revealed that this treatment was not an independent risk factor for SPNs (hazard ratio = 1.06, 95% CI: 0.88-1.26, P = .54). CONCLUSIONS: Patients with UM presented an 11% higher risk of SPNs compared to the reference population. Radiotherapy does not seem to be a risk factor. SPNs should be considered in the surveillance of UM. |
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Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database AnalysisAdolescentAdultChildChild, PreschoolDatabases, FactualFemaleHumansIncidenceInfantMaleMelanomaMiddle AgedNeoplasms, Second PrimaryProportional Hazards ModelsRetrospective StudiesRisk FactorsSEER ProgramUnited StatesUveal NeoplasmsCHLC ANSPURPOSE: To determine the risk of second primary neoplasms (SPNs) in subjects previously diagnosed with uveal melanoma (UM), including an analysis on whether radiotherapy is a risk factor to develop these SPNs. DESIGN: Retrospective cohort study. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) 9 database, we identified patients diagnosed with UM as their first malignancy between 1973 and 2011 (n = 3976). We obtained standardized incidence ratios (SIR) and excess absolute risks of SPNs on patients with UM compared to a reference population. Multivariate Cox regression models were used to evaluate the effect of radiotherapy in SPN risk. RESULTS: Sixteen percent (n = 641) of the patients developed SPNs during a median follow-up of 83 months (range, 1-463 months). This represented an 11% excess risk compared to the reference population, mainly owing to a significantly increased risk of skin melanomas (SIR = 2.93, 95% CI: 2.23-3.78) and kidney tumors (SIR = 1.91, 95% CI: 1.27-2.76), primarily in those diagnosed between 30 and 59 years of age. The occurrence of second UM was also increased (SIR = 16.90, 95% CI: 9.00-28.90), which likely includes recurrences misclassified as a second cancer. Radiotherapy was performed in 39% (n = 1538) of the patients. Multivariate analysis revealed that this treatment was not an independent risk factor for SPNs (hazard ratio = 1.06, 95% CI: 0.88-1.26, P = .54). CONCLUSIONS: Patients with UM presented an 11% higher risk of SPNs compared to the reference population. Radiotherapy does not seem to be a risk factor. SPNs should be considered in the surveillance of UM.Elsevier MassonRepositório do Centro Hospitalar Universitário de Lisboa Central, EPELaíns, IBartosch, CMondim, VHealy, BKim, IKHusain, DMiller, JW2017-06-08T15:02:58Z2016-052016-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2697engAm J Ophthalmol. 2016 May;165:54-6410.1016/j.ajo.2016.02.022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:11Zoai:repositorio.chlc.min-saude.pt:10400.17/2697Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:02.106347Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
title |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
spellingShingle |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis Laíns, I Adolescent Adult Child Child, Preschool Databases, Factual Female Humans Incidence Infant Male Melanoma Middle Aged Neoplasms, Second Primary Proportional Hazards Models Retrospective Studies Risk Factors SEER Program United States Uveal Neoplasms CHLC ANS |
title_short |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
title_full |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
title_fullStr |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
title_full_unstemmed |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
title_sort |
Second Primary Neoplasms in Patients With Uveal Melanoma: A SEER Database Analysis |
author |
Laíns, I |
author_facet |
Laíns, I Bartosch, C Mondim, V Healy, B Kim, IK Husain, D Miller, JW |
author_role |
author |
author2 |
Bartosch, C Mondim, V Healy, B Kim, IK Husain, D Miller, JW |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Laíns, I Bartosch, C Mondim, V Healy, B Kim, IK Husain, D Miller, JW |
dc.subject.por.fl_str_mv |
Adolescent Adult Child Child, Preschool Databases, Factual Female Humans Incidence Infant Male Melanoma Middle Aged Neoplasms, Second Primary Proportional Hazards Models Retrospective Studies Risk Factors SEER Program United States Uveal Neoplasms CHLC ANS |
topic |
Adolescent Adult Child Child, Preschool Databases, Factual Female Humans Incidence Infant Male Melanoma Middle Aged Neoplasms, Second Primary Proportional Hazards Models Retrospective Studies Risk Factors SEER Program United States Uveal Neoplasms CHLC ANS |
description |
PURPOSE: To determine the risk of second primary neoplasms (SPNs) in subjects previously diagnosed with uveal melanoma (UM), including an analysis on whether radiotherapy is a risk factor to develop these SPNs. DESIGN: Retrospective cohort study. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) 9 database, we identified patients diagnosed with UM as their first malignancy between 1973 and 2011 (n = 3976). We obtained standardized incidence ratios (SIR) and excess absolute risks of SPNs on patients with UM compared to a reference population. Multivariate Cox regression models were used to evaluate the effect of radiotherapy in SPN risk. RESULTS: Sixteen percent (n = 641) of the patients developed SPNs during a median follow-up of 83 months (range, 1-463 months). This represented an 11% excess risk compared to the reference population, mainly owing to a significantly increased risk of skin melanomas (SIR = 2.93, 95% CI: 2.23-3.78) and kidney tumors (SIR = 1.91, 95% CI: 1.27-2.76), primarily in those diagnosed between 30 and 59 years of age. The occurrence of second UM was also increased (SIR = 16.90, 95% CI: 9.00-28.90), which likely includes recurrences misclassified as a second cancer. Radiotherapy was performed in 39% (n = 1538) of the patients. Multivariate analysis revealed that this treatment was not an independent risk factor for SPNs (hazard ratio = 1.06, 95% CI: 0.88-1.26, P = .54). CONCLUSIONS: Patients with UM presented an 11% higher risk of SPNs compared to the reference population. Radiotherapy does not seem to be a risk factor. SPNs should be considered in the surveillance of UM. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-05 2016-05-01T00:00:00Z 2017-06-08T15:02:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2697 |
url |
http://hdl.handle.net/10400.17/2697 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Am J Ophthalmol. 2016 May;165:54-64 10.1016/j.ajo.2016.02.022 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Masson |
publisher.none.fl_str_mv |
Elsevier Masson |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131296958513152 |