ß-Lactams: chemical structure, mode of action and mechanisms of resistance

Detalhes bibliográficos
Autor(a) principal: Fernandes, Rúben
Data de Publicação: 2013
Outros Autores: Amador, Paula, Prudêncio, Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/7041
Resumo: This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This review also summarizes the main resistance mechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell.
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spelling ß-Lactams: chemical structure, mode of action and mechanisms of resistanceThis synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This review also summarizes the main resistance mechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell.Wolters Kluwer Health | Lippincott Williams & WilkinsRepositório Científico do Instituto Politécnico do PortoFernandes, RúbenAmador, PaulaPrudêncio, Cristina2020-01-01T01:30:13Z20132013-07-25T20:43:23Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/7041engFernandes, Rúben; Amador, Paula; Prudêncio, Cristina. ß-Lactams: chemical structure, mode of action and mechanisms of resistance, Reviews in Medical Microbiology, 24, 1, 7-17, 2013.10.1097/MRM.0b013e3283587727info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:41:16Zoai:recipp.ipp.pt:10400.22/7041Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:22:56.608837Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv ß-Lactams: chemical structure, mode of action and mechanisms of resistance
title ß-Lactams: chemical structure, mode of action and mechanisms of resistance
spellingShingle ß-Lactams: chemical structure, mode of action and mechanisms of resistance
Fernandes, Rúben
title_short ß-Lactams: chemical structure, mode of action and mechanisms of resistance
title_full ß-Lactams: chemical structure, mode of action and mechanisms of resistance
title_fullStr ß-Lactams: chemical structure, mode of action and mechanisms of resistance
title_full_unstemmed ß-Lactams: chemical structure, mode of action and mechanisms of resistance
title_sort ß-Lactams: chemical structure, mode of action and mechanisms of resistance
author Fernandes, Rúben
author_facet Fernandes, Rúben
Amador, Paula
Prudêncio, Cristina
author_role author
author2 Amador, Paula
Prudêncio, Cristina
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Fernandes, Rúben
Amador, Paula
Prudêncio, Cristina
description This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This review also summarizes the main resistance mechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-07-25T20:43:23Z
2013-01-01T00:00:00Z
2020-01-01T01:30:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/7041
url http://hdl.handle.net/10400.22/7041
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes, Rúben; Amador, Paula; Prudêncio, Cristina. ß-Lactams: chemical structure, mode of action and mechanisms of resistance, Reviews in Medical Microbiology, 24, 1, 7-17, 2013.
10.1097/MRM.0b013e3283587727
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health | Lippincott Williams & Wilkins
publisher.none.fl_str_mv Wolters Kluwer Health | Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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