An integrative approach for codon repeats evolutionary analyses

Detalhes bibliográficos
Autor(a) principal: Lousado, José Paulo
Data de Publicação: 2012
Outros Autores: Oliveira, José Luis, Moura, Gabriela, Santos, Manuel A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/27635
Resumo: The relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering.
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spelling An integrative approach for codon repeats evolutionary analysesCodon repeatsEvolutionary analysesOrthologous genesGene comparisonTandem repeatsData integrationWeb servicesBioinformaticsThe relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering.Inderscience2020-02-26T09:47:41Z2012-01-01T00:00:00Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27635eng1748-567310.1504/ijdmb.2012.049294Lousado, José PauloOliveira, José LuisMoura, GabrielaSantos, Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:53:34Zoai:ria.ua.pt:10773/27635Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:22.636860Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An integrative approach for codon repeats evolutionary analyses
title An integrative approach for codon repeats evolutionary analyses
spellingShingle An integrative approach for codon repeats evolutionary analyses
Lousado, José Paulo
Codon repeats
Evolutionary analyses
Orthologous genes
Gene comparison
Tandem repeats
Data integration
Web services
Bioinformatics
title_short An integrative approach for codon repeats evolutionary analyses
title_full An integrative approach for codon repeats evolutionary analyses
title_fullStr An integrative approach for codon repeats evolutionary analyses
title_full_unstemmed An integrative approach for codon repeats evolutionary analyses
title_sort An integrative approach for codon repeats evolutionary analyses
author Lousado, José Paulo
author_facet Lousado, José Paulo
Oliveira, José Luis
Moura, Gabriela
Santos, Manuel A. S.
author_role author
author2 Oliveira, José Luis
Moura, Gabriela
Santos, Manuel A. S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Lousado, José Paulo
Oliveira, José Luis
Moura, Gabriela
Santos, Manuel A. S.
dc.subject.por.fl_str_mv Codon repeats
Evolutionary analyses
Orthologous genes
Gene comparison
Tandem repeats
Data integration
Web services
Bioinformatics
topic Codon repeats
Evolutionary analyses
Orthologous genes
Gene comparison
Tandem repeats
Data integration
Web services
Bioinformatics
description The relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01T00:00:00Z
2012
2020-02-26T09:47:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/27635
url http://hdl.handle.net/10773/27635
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1748-5673
10.1504/ijdmb.2012.049294
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Inderscience
publisher.none.fl_str_mv Inderscience
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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