An integrative approach for codon repeats evolutionary analyses
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/27635 |
Resumo: | The relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering. |
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An integrative approach for codon repeats evolutionary analysesCodon repeatsEvolutionary analysesOrthologous genesGene comparisonTandem repeatsData integrationWeb servicesBioinformaticsThe relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering.Inderscience2020-02-26T09:47:41Z2012-01-01T00:00:00Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27635eng1748-567310.1504/ijdmb.2012.049294Lousado, José PauloOliveira, José LuisMoura, GabrielaSantos, Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:53:34Zoai:ria.ua.pt:10773/27635Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:22.636860Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
An integrative approach for codon repeats evolutionary analyses |
title |
An integrative approach for codon repeats evolutionary analyses |
spellingShingle |
An integrative approach for codon repeats evolutionary analyses Lousado, José Paulo Codon repeats Evolutionary analyses Orthologous genes Gene comparison Tandem repeats Data integration Web services Bioinformatics |
title_short |
An integrative approach for codon repeats evolutionary analyses |
title_full |
An integrative approach for codon repeats evolutionary analyses |
title_fullStr |
An integrative approach for codon repeats evolutionary analyses |
title_full_unstemmed |
An integrative approach for codon repeats evolutionary analyses |
title_sort |
An integrative approach for codon repeats evolutionary analyses |
author |
Lousado, José Paulo |
author_facet |
Lousado, José Paulo Oliveira, José Luis Moura, Gabriela Santos, Manuel A. S. |
author_role |
author |
author2 |
Oliveira, José Luis Moura, Gabriela Santos, Manuel A. S. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lousado, José Paulo Oliveira, José Luis Moura, Gabriela Santos, Manuel A. S. |
dc.subject.por.fl_str_mv |
Codon repeats Evolutionary analyses Orthologous genes Gene comparison Tandem repeats Data integration Web services Bioinformatics |
topic |
Codon repeats Evolutionary analyses Orthologous genes Gene comparison Tandem repeats Data integration Web services Bioinformatics |
description |
The relationship between genome characteristics and several human diseases has been a central research goal in genomics. Many studies have shown that specific gene patterns, such as amino acid repetitions, are associated with human diseases. However, several open questions still remain, such as, how these tandem repeats appeared in the evolutionary path or how they have evolved in orthologous genes of related organisms. In this paper, we present a computational solution that facilitates comparative studies of orthologous genes from various organisms. The application uses various web services to gather gene sequence information, local algorithms for tandem repeats identification and similarity measures for gene clustering. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01T00:00:00Z 2012 2020-02-26T09:47:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/27635 |
url |
http://hdl.handle.net/10773/27635 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1748-5673 10.1504/ijdmb.2012.049294 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Inderscience |
publisher.none.fl_str_mv |
Inderscience |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137659459731456 |