Effects of combined training with different intensities on vascular health in patients with type 2 diabetes

Detalhes bibliográficos
Autor(a) principal: Magalhães, João P.
Data de Publicação: 2019
Outros Autores: Melo, Xavier, Correia, Inês R., Ribeiro, Rogério T., Raposo, João, Dores, Hélder, Bicho, Manuel, Sardinha, Luís B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.1186/s12933-019-0840-2
Texto Completo: https://doi.org/10.1186/s12933-019-0840-2
Resumo: The authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019).
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spelling Effects of combined training with different intensities on vascular health in patients with type 2 diabetesA 1-year randomized controlled trialArterial stiffnessDistensibility coefficientHigh-intensity interval trainingIntima-media thicknessModerate continuous trainingPulse wave velocityInternal MedicineEndocrinology, Diabetes and MetabolismCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingThe authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019).Background: Exercise, when performed on a regular basis, is a well-accepted strategy to improve vascular function in patients with type 2 diabetes. However, the exercise intensity that yields maximal adaptations on structural and functional indices in patients with type 2 diabetes remains uncertain. Our objective was to analyze the impact of a 1-year randomized controlled trial of combined high-intensity interval training (HIIT) with resistance training (RT) vs. a combined moderate continuous training (MCT) with RT on structural and functional arterial indices in patients with type 2 diabetes. Methods: Patients with type 2 diabetes (n = 80) were randomized into an exercise intervention with three groups: control, combined HIIT with RT and combined MCT with RT. The 1-year intervention had 3 weekly exercise sessions. High-resolution ultrasonography of the common carotid artery and central and peripheral applanation tonometry were used to assess the changes in structural and functional arterial indices. Generalized estimating equations were used to model the corresponding outcomes. Results: After adjusting the models for sex, baseline moderate-to-vigorous physical activity, and mean arterial pressure changes, while using the intention-to-treat analysis, a significant interaction was observed on the carotid intima-media thickness (cIMT) for both the MCT (β = - 4.25, p < 0.01) and HIIT group (β = - 3.61, p < 0.01). However, only the HIIT observed favorable changes from baseline to 1-year on peripheral arterial stiffness indices such as carotid radial arterial pulse wave velocity (β = - 0.10, p = 0.044), carotid to distal posterior tibial artery pulse wave velocity (β = - 0.14, p < 0.01), and on the distensibility coefficient (β = - 0.00, p < 0.01). No effect was found for hemodynamic variables after the intervention. Conclusions: Following a 1-year intervention in patients with type 2 diabetes, both the MCT and HIIT group reduced their cIMT, whereas only the HIIT group improved their peripheral arterial stiffness indices and distensibility coefficient. Taken together, HIIT may be a meaningful tool to improve long-term vascular complications in type 2 diabetes. Trial registration clinicaltrials.gov ID: NCT03144505NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMagalhães, João P.Melo, XavierCorreia, Inês R.Ribeiro, Rogério T.Raposo, JoãoDores, HélderBicho, ManuelSardinha, Luís B.2019-03-28T23:29:49Z2019-03-182019-03-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1186/s12933-019-0840-2eng1475-2840PURE: 12429192http://www.scopus.com/inward/record.url?scp=85063140457&partnerID=8YFLogxKhttps://doi.org/10.1186/s12933-019-0840-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:38:17Zoai:run.unl.pt:10362/64924Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:38:17Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
A 1-year randomized controlled trial
title Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
spellingShingle Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
Magalhães, João P.
Arterial stiffness
Distensibility coefficient
High-intensity interval training
Intima-media thickness
Moderate continuous training
Pulse wave velocity
Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
Magalhães, João P.
Arterial stiffness
Distensibility coefficient
High-intensity interval training
Intima-media thickness
Moderate continuous training
Pulse wave velocity
Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
title_short Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
title_full Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
title_fullStr Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
title_full_unstemmed Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
title_sort Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
author Magalhães, João P.
author_facet Magalhães, João P.
Magalhães, João P.
Melo, Xavier
Correia, Inês R.
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
Melo, Xavier
Correia, Inês R.
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
author_role author
author2 Melo, Xavier
Correia, Inês R.
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Magalhães, João P.
Melo, Xavier
Correia, Inês R.
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
dc.subject.por.fl_str_mv Arterial stiffness
Distensibility coefficient
High-intensity interval training
Intima-media thickness
Moderate continuous training
Pulse wave velocity
Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
topic Arterial stiffness
Distensibility coefficient
High-intensity interval training
Intima-media thickness
Moderate continuous training
Pulse wave velocity
Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine
SDG 3 - Good Health and Well-being
description The authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019).
publishDate 2019
dc.date.none.fl_str_mv 2019-03-28T23:29:49Z
2019-03-18
2019-03-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1186/s12933-019-0840-2
url https://doi.org/10.1186/s12933-019-0840-2
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1475-2840
PURE: 12429192
http://www.scopus.com/inward/record.url?scp=85063140457&partnerID=8YFLogxK
https://doi.org/10.1186/s12933-019-0840-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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dc.identifier.doi.none.fl_str_mv 10.1186/s12933-019-0840-2