Effects of combined training with different intensities on vascular health in patients with type 2 diabetes
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
DOI: | 10.1186/s12933-019-0840-2 |
Texto Completo: | https://doi.org/10.1186/s12933-019-0840-2 |
Resumo: | The authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019). |
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Effects of combined training with different intensities on vascular health in patients with type 2 diabetesA 1-year randomized controlled trialArterial stiffnessDistensibility coefficientHigh-intensity interval trainingIntima-media thicknessModerate continuous trainingPulse wave velocityInternal MedicineEndocrinology, Diabetes and MetabolismCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingThe authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019).Background: Exercise, when performed on a regular basis, is a well-accepted strategy to improve vascular function in patients with type 2 diabetes. However, the exercise intensity that yields maximal adaptations on structural and functional indices in patients with type 2 diabetes remains uncertain. Our objective was to analyze the impact of a 1-year randomized controlled trial of combined high-intensity interval training (HIIT) with resistance training (RT) vs. a combined moderate continuous training (MCT) with RT on structural and functional arterial indices in patients with type 2 diabetes. Methods: Patients with type 2 diabetes (n = 80) were randomized into an exercise intervention with three groups: control, combined HIIT with RT and combined MCT with RT. The 1-year intervention had 3 weekly exercise sessions. High-resolution ultrasonography of the common carotid artery and central and peripheral applanation tonometry were used to assess the changes in structural and functional arterial indices. Generalized estimating equations were used to model the corresponding outcomes. Results: After adjusting the models for sex, baseline moderate-to-vigorous physical activity, and mean arterial pressure changes, while using the intention-to-treat analysis, a significant interaction was observed on the carotid intima-media thickness (cIMT) for both the MCT (β = - 4.25, p < 0.01) and HIIT group (β = - 3.61, p < 0.01). However, only the HIIT observed favorable changes from baseline to 1-year on peripheral arterial stiffness indices such as carotid radial arterial pulse wave velocity (β = - 0.10, p = 0.044), carotid to distal posterior tibial artery pulse wave velocity (β = - 0.14, p < 0.01), and on the distensibility coefficient (β = - 0.00, p < 0.01). No effect was found for hemodynamic variables after the intervention. Conclusions: Following a 1-year intervention in patients with type 2 diabetes, both the MCT and HIIT group reduced their cIMT, whereas only the HIIT group improved their peripheral arterial stiffness indices and distensibility coefficient. Taken together, HIIT may be a meaningful tool to improve long-term vascular complications in type 2 diabetes. Trial registration clinicaltrials.gov ID: NCT03144505NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMagalhães, João P.Melo, XavierCorreia, Inês R.Ribeiro, Rogério T.Raposo, JoãoDores, HélderBicho, ManuelSardinha, Luís B.2019-03-28T23:29:49Z2019-03-182019-03-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1186/s12933-019-0840-2eng1475-2840PURE: 12429192http://www.scopus.com/inward/record.url?scp=85063140457&partnerID=8YFLogxKhttps://doi.org/10.1186/s12933-019-0840-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:38:17Zoai:run.unl.pt:10362/64924Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:38:17Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes A 1-year randomized controlled trial |
title |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes |
spellingShingle |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes Effects of combined training with different intensities on vascular health in patients with type 2 diabetes Magalhães, João P. Arterial stiffness Distensibility coefficient High-intensity interval training Intima-media thickness Moderate continuous training Pulse wave velocity Internal Medicine Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being Magalhães, João P. Arterial stiffness Distensibility coefficient High-intensity interval training Intima-media thickness Moderate continuous training Pulse wave velocity Internal Medicine Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
title_short |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes |
title_full |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes |
title_fullStr |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes Effects of combined training with different intensities on vascular health in patients with type 2 diabetes |
title_full_unstemmed |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes Effects of combined training with different intensities on vascular health in patients with type 2 diabetes |
title_sort |
Effects of combined training with different intensities on vascular health in patients with type 2 diabetes |
author |
Magalhães, João P. |
author_facet |
Magalhães, João P. Magalhães, João P. Melo, Xavier Correia, Inês R. Ribeiro, Rogério T. Raposo, João Dores, Hélder Bicho, Manuel Sardinha, Luís B. Melo, Xavier Correia, Inês R. Ribeiro, Rogério T. Raposo, João Dores, Hélder Bicho, Manuel Sardinha, Luís B. |
author_role |
author |
author2 |
Melo, Xavier Correia, Inês R. Ribeiro, Rogério T. Raposo, João Dores, Hélder Bicho, Manuel Sardinha, Luís B. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Magalhães, João P. Melo, Xavier Correia, Inês R. Ribeiro, Rogério T. Raposo, João Dores, Hélder Bicho, Manuel Sardinha, Luís B. |
dc.subject.por.fl_str_mv |
Arterial stiffness Distensibility coefficient High-intensity interval training Intima-media thickness Moderate continuous training Pulse wave velocity Internal Medicine Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
topic |
Arterial stiffness Distensibility coefficient High-intensity interval training Intima-media thickness Moderate continuous training Pulse wave velocity Internal Medicine Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
description |
The authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-28T23:29:49Z 2019-03-18 2019-03-18T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1186/s12933-019-0840-2 |
url |
https://doi.org/10.1186/s12933-019-0840-2 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1475-2840 PURE: 12429192 http://www.scopus.com/inward/record.url?scp=85063140457&partnerID=8YFLogxK https://doi.org/10.1186/s12933-019-0840-2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1822227464160542720 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s12933-019-0840-2 |