Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial

Detalhes bibliográficos
Autor(a) principal: Magalhães, João P.
Data de Publicação: 2019
Outros Autores: Melo, Xavier, Correia, Inês, Ribeiro, Rogério T., Raposo, João, Dores, Hélder, Bicho, Manuel, Sardinha, Luís B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/39651
Resumo: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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spelling Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trialHigh-intensity interval trainingArterial stifnessModerate continuous trainingIntima-media thicknessDistensibility coefcientPulse wave velocity© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Exercise, when performed on a regular basis, is a well-accepted strategy to improve vascular function in patients with type 2 diabetes. However, the exercise intensity that yields maximal adaptations on structural and functional indices in patients with type 2 diabetes remains uncertain. Our objective was to analyze the impact of a 1-year randomized controlled trial of combined high-intensity interval training (HIIT) with resistance training (RT) vs. a combined moderate continuous training (MCT) with RT on structural and functional arterial indices in patients with type 2 diabetes. Methods: Patients with type 2 diabetes (n=80) were randomized into an exercise intervention with three groups: control, combined HIIT with RT and combined MCT with RT. The 1-year intervention had 3 weekly exercise sessions. High-resolution ultrasonography of the common carotid artery and central and peripheral applanation tonometry were used to assess the changes in structural and functional arterial indices. Generalized estimating equations were used to model the corresponding outcomes. Results: After adjusting the models for sex, baseline moderate-to-vigorous physical activity, and mean arterial pressure changes, while using the intention-to-treat analysis, a signifcant interaction was observed on the carotid intimamedia thickness (cIMT) for both the MCT (β=−4.25, p<0.01) and HIIT group (β=−3.61, p<0.01). However, only the HIIT observed favorable changes from baseline to 1-year on peripheral arterial stifness indices such as carotid radial arterial pulse wave velocity (β=−0.10, p=0.044), carotid to distal posterior tibial artery pulse wave velocity (β=−0.14, p<0.01), and on the distensibility coefcient (β=−0.00, p<0.01). No efect was found for hemodynamic variables after the intervention. Conclusions: Following a 1-year intervention in patients with type 2 diabetes, both the MCT and HIIT group reduced their cIMT, whereas only the HIIT group improved their peripheral arterial stifness indices and distensibility coefcient. Taken together, HIIT may be a meaningful tool to improve long-term vascular complications in type 2 diabetes.The authors declare that the research was conducted in the absence of any commercial or fnancial relationships that could be construed as a potential competing interest. JM and RTR are supported by a scholarship from the Portuguese Foundation for Science and Technology (JM grant: SFRH/ BD/85742/2012, RTR grant: SFRH/BPD/110426/2015). This work is also fnanced by a national grant through the FCT—Fundação para a Ciência e Tecnologia within the unit I&D 472 (UID/DTP/00447/2019).BMCRepositório da Universidade de LisboaMagalhães, João P.Melo, XavierCorreia, InêsRibeiro, Rogério T.Raposo, JoãoDores, HélderBicho, ManuelSardinha, Luís B.2019-09-30T13:30:43Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/39651engCardiovasc Diabetol. 2019 Mar 18;18(1):34.1475-284010.1186/s12933-019-0840-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T17:53:34Zoai:repositorio.ul.pt:10451/39651Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T17:53:34Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
title Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
spellingShingle Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
Magalhães, João P.
High-intensity interval training
Arterial stifness
Moderate continuous training
Intima-media thickness
Distensibility coefcient
Pulse wave velocity
title_short Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
title_full Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
title_fullStr Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
title_full_unstemmed Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
title_sort Effects of combined training with different intensities on vascular health in patients with type 2 diabetes : a 1-year randomized controlled trial
author Magalhães, João P.
author_facet Magalhães, João P.
Melo, Xavier
Correia, Inês
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
author_role author
author2 Melo, Xavier
Correia, Inês
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Magalhães, João P.
Melo, Xavier
Correia, Inês
Ribeiro, Rogério T.
Raposo, João
Dores, Hélder
Bicho, Manuel
Sardinha, Luís B.
dc.subject.por.fl_str_mv High-intensity interval training
Arterial stifness
Moderate continuous training
Intima-media thickness
Distensibility coefcient
Pulse wave velocity
topic High-intensity interval training
Arterial stifness
Moderate continuous training
Intima-media thickness
Distensibility coefcient
Pulse wave velocity
description © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-30T13:30:43Z
2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/39651
url http://hdl.handle.net/10451/39651
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cardiovasc Diabetol. 2019 Mar 18;18(1):34.
1475-2840
10.1186/s12933-019-0840-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv BMC
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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