Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles

Detalhes bibliográficos
Autor(a) principal: Figari, Giorgia
Data de Publicação: 2023
Outros Autores: Gonçalves, José L.M., Diogo, Hermínio P., Dionísio, Madalena, Farinha, José Paulo, Viciosa, María Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158331
Resumo: Funding Information: This work was supported by Fundação para a Ciência e a Tecnologia (FCT-Portugal) and COMPETE (FEDER), projects UIDB/00100/2020 and UIDP/00100/2020 (CQE). Publisher Copyright: © 2023 by the authors.
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spelling Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticlesamorphous stateconfined waterdrug releasefenofibratemesoporous silica nanoparticlesPharmaceutical ScienceFunding Information: This work was supported by Fundação para a Ciência e a Tecnologia (FCT-Portugal) and COMPETE (FEDER), projects UIDB/00100/2020 and UIDP/00100/2020 (CQE). Publisher Copyright: © 2023 by the authors.To investigate the impact of the surface functionalization of mesoporous silica nanoparticle (MSN) carriers in the physical state, molecular mobility and the release of Fenofibrate (FNB) MSNs with ordered cylindrical pores were prepared. The surface of the MSNs was modified with either (3-aminopropyl) triethoxysilane (APTES) or trimethoxy(phenyl)silane (TMPS), and the density of the grafted functional groups was quantified via 1H-NMR. The incorporation in the ~3 nm pores of the MSNs promoted FNB amorphization, as evidenced via FTIR, DSC and dielectric analysis, showing no tendency to undergo recrystallization in opposition to the neat drug. Moreover, the onset of the glass transition was slightly shifted to lower temperatures when the drug was loaded in unmodified MSNs, and MSNs modified with APTES composite, while it increased in the case of TMPS-modified MSNs. Dielectric studies have confirmed these changes and allowed researchers to disclose the broad glass transition in multiple relaxations associated with different FNB populations. Moreover, DRS showed relaxation processes in dehydrated composites associated with surface-anchored FNB molecules whose mobility showed a correlation with the observed drug release profiles.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNFigari, GiorgiaGonçalves, José L.M.Diogo, Hermínio P.Dionísio, MadalenaFarinha, José PauloViciosa, María Teresa2023-09-26T22:21:13Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27application/pdfhttp://hdl.handle.net/10362/158331eng1999-4923PURE: 72479221https://doi.org/10.3390/pharmaceutics15061624info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:39Zoai:run.unl.pt:10362/158331Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:04.755237Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
title Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
spellingShingle Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
Figari, Giorgia
amorphous state
confined water
drug release
fenofibrate
mesoporous silica nanoparticles
Pharmaceutical Science
title_short Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
title_full Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
title_fullStr Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
title_full_unstemmed Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
title_sort Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles
author Figari, Giorgia
author_facet Figari, Giorgia
Gonçalves, José L.M.
Diogo, Hermínio P.
Dionísio, Madalena
Farinha, José Paulo
Viciosa, María Teresa
author_role author
author2 Gonçalves, José L.M.
Diogo, Hermínio P.
Dionísio, Madalena
Farinha, José Paulo
Viciosa, María Teresa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Figari, Giorgia
Gonçalves, José L.M.
Diogo, Hermínio P.
Dionísio, Madalena
Farinha, José Paulo
Viciosa, María Teresa
dc.subject.por.fl_str_mv amorphous state
confined water
drug release
fenofibrate
mesoporous silica nanoparticles
Pharmaceutical Science
topic amorphous state
confined water
drug release
fenofibrate
mesoporous silica nanoparticles
Pharmaceutical Science
description Funding Information: This work was supported by Fundação para a Ciência e a Tecnologia (FCT-Portugal) and COMPETE (FEDER), projects UIDB/00100/2020 and UIDP/00100/2020 (CQE). Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-26T22:21:13Z
2023-06
2023-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158331
url http://hdl.handle.net/10362/158331
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 72479221
https://doi.org/10.3390/pharmaceutics15061624
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 27
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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