From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases

Detalhes bibliográficos
Autor(a) principal: Caseiro, Catarina
Data de Publicação: 2022
Outros Autores: Dias, Joana N. R., Fontes, Carlos M.G.A., Bule, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24157
Resumo: Research Areas: Biochemistry & Molecular Biology ; Chemistry
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spelling From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanasesβ-glucansβ-glucanasesMolecular structureCancerDectin-1CR3VaccinesResearch Areas: Biochemistry & Molecular Biology ; Chemistry: β-glucans are a diverse group of polysaccharides composed of β-1,3 or β-(1,3-1,4) linked glucose monomers. They are mainly synthesized by fungi, plants, seaweed and bacteria, where they carry out structural, protective and energy storage roles. Because of their unique physicochemical properties, they have important applications in several industrial, biomedical and biotechnological processes. β-glucans are also major bioactive molecules with marked immunomodulatory and metabolic properties. As such, they have been the focus of many studies attesting to their ability to, among other roles, fight cancer, reduce the risk of cardiovascular diseases and control diabetes. The physicochemical and functional profiles of β-glucans are deeply influenced by their molecular structure. This structure governs β-glucan interaction with multiple β-glucan binding proteins, triggering myriad biological responses. It is then imperative to understand the structural properties of β-glucans to fully reveal their biological roles and potential applications. The deconstruction of β-glucans is a result of β-glucanase activity. In addition to being invaluable tools for the study of β-glucans, these enzymes have applications in numerous biotechnological and industrial processes, both alone and in conjunction with their natural substrates. Here, we review potential applications for β-glucans and β-glucanases, and explore how their functionalities are dictated by their structure.MDPIRepositório da Universidade de LisboaCaseiro, CatarinaDias, Joana N. R.Fontes, Carlos M.G.A.Bule, Pedro2022-04-25T21:52:29Z2022-03-152022-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24157engCaseiro C, Dias JNR, Andrade Fontes CMG, Bule P. 2022. From cancer therapy to winemaking : the molecular structure and applications of β-Glucans and β-1, 3-Glucanases. International Journal of Molecular Sciences, 23(6):3156. Doi 10.3390/ ijms2306315610.3390/ ijms230631561422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:48Zoai:www.repository.utl.pt:10400.5/24157Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:15.965796Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
title From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
spellingShingle From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
Caseiro, Catarina
β-glucans
β-glucanases
Molecular structure
Cancer
Dectin-1
CR3
Vaccines
title_short From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
title_full From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
title_fullStr From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
title_full_unstemmed From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
title_sort From cancer therapy to winemaking : the molecular structure and applications of beta-Glucans and beta-1, 3-Glucanases
author Caseiro, Catarina
author_facet Caseiro, Catarina
Dias, Joana N. R.
Fontes, Carlos M.G.A.
Bule, Pedro
author_role author
author2 Dias, Joana N. R.
Fontes, Carlos M.G.A.
Bule, Pedro
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Caseiro, Catarina
Dias, Joana N. R.
Fontes, Carlos M.G.A.
Bule, Pedro
dc.subject.por.fl_str_mv β-glucans
β-glucanases
Molecular structure
Cancer
Dectin-1
CR3
Vaccines
topic β-glucans
β-glucanases
Molecular structure
Cancer
Dectin-1
CR3
Vaccines
description Research Areas: Biochemistry & Molecular Biology ; Chemistry
publishDate 2022
dc.date.none.fl_str_mv 2022-04-25T21:52:29Z
2022-03-15
2022-03-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24157
url http://hdl.handle.net/10400.5/24157
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Caseiro C, Dias JNR, Andrade Fontes CMG, Bule P. 2022. From cancer therapy to winemaking : the molecular structure and applications of β-Glucans and β-1, 3-Glucanases. International Journal of Molecular Sciences, 23(6):3156. Doi 10.3390/ ijms23063156
10.3390/ ijms23063156
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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