Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour?
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/29852 https://doi.org/10.1016/j.jri.2015.10.002 |
Resumo: | Progesterone acts as an immunosteroid by contributing to the establishment of a pregnancy-protective milieu. It seems that it is the responsibility of progesterone to evade the inflammatory events that lead to parturition. T regulatory lymphocytes (Treg cells) could further explain the inhibition of the inflammatory mechanisms that lead to labour through the rapid action of progesterone on this cell subset. We investigated Treg cells and the membrane progesterone receptor α (mPRα) in these immune cells with in relationship to human parturition. This pilot cohort study was conducted in a single-centre tertiary obstetrical unit with 20 normal pregnant women. Variation in the absolute and relative frequency of CD4+ T cells, Treg cells, and of mPRα+ Treg cells was calculated by flow cytometry on three occasions (second and third trimesters; delivery day). Our results show that during normal pregnancy there is a generalised increase in Treg cells and mPRα+ Treg cells, from the second to the third trimesters (23.4% vs. 52.3% and 4.3% vs. 8.3%, respectively). On the contrary, on delivery day, compared with the values in the third trimester, there is a sudden decrease in both Treg cells (52.3% vs. 17.4%) and mPRα+ Treg cells (8.3% vs. 6.1%). Our findings suggest that human labour may develop as a consequence of a decline in mPRα+ Treg cells, which reduces progesterone anti-inflammatory action through Treg cells. |
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Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour?LabourProgesteronemPRalphaTregsPregnancyProgesterone acts as an immunosteroid by contributing to the establishment of a pregnancy-protective milieu. It seems that it is the responsibility of progesterone to evade the inflammatory events that lead to parturition. T regulatory lymphocytes (Treg cells) could further explain the inhibition of the inflammatory mechanisms that lead to labour through the rapid action of progesterone on this cell subset. We investigated Treg cells and the membrane progesterone receptor α (mPRα) in these immune cells with in relationship to human parturition. This pilot cohort study was conducted in a single-centre tertiary obstetrical unit with 20 normal pregnant women. Variation in the absolute and relative frequency of CD4+ T cells, Treg cells, and of mPRα+ Treg cells was calculated by flow cytometry on three occasions (second and third trimesters; delivery day). Our results show that during normal pregnancy there is a generalised increase in Treg cells and mPRα+ Treg cells, from the second to the third trimesters (23.4% vs. 52.3% and 4.3% vs. 8.3%, respectively). On the contrary, on delivery day, compared with the values in the third trimester, there is a sudden decrease in both Treg cells (52.3% vs. 17.4%) and mPRα+ Treg cells (8.3% vs. 6.1%). Our findings suggest that human labour may develop as a consequence of a decline in mPRα+ Treg cells, which reduces progesterone anti-inflammatory action through Treg cells.2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/29852http://hdl.handle.net/10316/29852https://doi.org/10.1016/j.jri.2015.10.002enghttp://www.sciencedirect.com/science/article/pii/S0165037815300371Areia, AnaVale-Pereira, SofiaAlves, VeraRodrigues-Santos, PauloSantos-Rosa, ManuelMoura, PauloMota-Pinto, Anabelainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T04:46:17Zoai:estudogeral.uc.pt:10316/29852Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:38.792634Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
title |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
spellingShingle |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? Areia, Ana Labour Progesterone mPRalpha Tregs Pregnancy |
title_short |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
title_full |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
title_fullStr |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
title_full_unstemmed |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
title_sort |
Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour? |
author |
Areia, Ana |
author_facet |
Areia, Ana Vale-Pereira, Sofia Alves, Vera Rodrigues-Santos, Paulo Santos-Rosa, Manuel Moura, Paulo Mota-Pinto, Anabela |
author_role |
author |
author2 |
Vale-Pereira, Sofia Alves, Vera Rodrigues-Santos, Paulo Santos-Rosa, Manuel Moura, Paulo Mota-Pinto, Anabela |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Areia, Ana Vale-Pereira, Sofia Alves, Vera Rodrigues-Santos, Paulo Santos-Rosa, Manuel Moura, Paulo Mota-Pinto, Anabela |
dc.subject.por.fl_str_mv |
Labour Progesterone mPRalpha Tregs Pregnancy |
topic |
Labour Progesterone mPRalpha Tregs Pregnancy |
description |
Progesterone acts as an immunosteroid by contributing to the establishment of a pregnancy-protective milieu. It seems that it is the responsibility of progesterone to evade the inflammatory events that lead to parturition. T regulatory lymphocytes (Treg cells) could further explain the inhibition of the inflammatory mechanisms that lead to labour through the rapid action of progesterone on this cell subset. We investigated Treg cells and the membrane progesterone receptor α (mPRα) in these immune cells with in relationship to human parturition. This pilot cohort study was conducted in a single-centre tertiary obstetrical unit with 20 normal pregnant women. Variation in the absolute and relative frequency of CD4+ T cells, Treg cells, and of mPRα+ Treg cells was calculated by flow cytometry on three occasions (second and third trimesters; delivery day). Our results show that during normal pregnancy there is a generalised increase in Treg cells and mPRα+ Treg cells, from the second to the third trimesters (23.4% vs. 52.3% and 4.3% vs. 8.3%, respectively). On the contrary, on delivery day, compared with the values in the third trimester, there is a sudden decrease in both Treg cells (52.3% vs. 17.4%) and mPRα+ Treg cells (8.3% vs. 6.1%). Our findings suggest that human labour may develop as a consequence of a decline in mPRα+ Treg cells, which reduces progesterone anti-inflammatory action through Treg cells. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/29852 http://hdl.handle.net/10316/29852 https://doi.org/10.1016/j.jri.2015.10.002 |
url |
http://hdl.handle.net/10316/29852 https://doi.org/10.1016/j.jri.2015.10.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S0165037815300371 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133708528123904 |