On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

Detalhes bibliográficos
Autor(a) principal: Ventura, Célia
Data de Publicação: 2020
Outros Autores: Pinto, Fátima V., Lourenço, Ana Filipa, Ferreira, Paulo Jorge Tavares, Louro, Henriqueta, Silva, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/89368
https://doi.org/10.1007/s10570-020-03176-9
Resumo: The need for reaching environmental sustainability encourages research on new cellulose-based materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a top-down approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.
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spelling On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular modelsCellulose nanocrystalsCellulose nanofibrilsNanocellulose productionGenotoxicityImmunotoxicityNanotoxicologyThe need for reaching environmental sustainability encourages research on new cellulose-based materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a top-down approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.Springer2020-04-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/89368http://hdl.handle.net/10316/89368https://doi.org/10.1007/s10570-020-03176-9eng0969-02391572-882Xhttps://link.springer.com/article/10.1007%2Fs10570-020-03176-9Ventura, CéliaPinto, Fátima V.Lourenço, Ana FilipaFerreira, Paulo Jorge TavaresLouro, HenriquetaSilva, Maria Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-25T09:00:18Zoai:estudogeral.uc.pt:10316/89368Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:09:42.536021Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
spellingShingle On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
Ventura, Célia
Cellulose nanocrystals
Cellulose nanofibrils
Nanocellulose production
Genotoxicity
Immunotoxicity
Nanotoxicology
title_short On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_full On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_fullStr On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_full_unstemmed On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_sort On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
author Ventura, Célia
author_facet Ventura, Célia
Pinto, Fátima V.
Lourenço, Ana Filipa
Ferreira, Paulo Jorge Tavares
Louro, Henriqueta
Silva, Maria João
author_role author
author2 Pinto, Fátima V.
Lourenço, Ana Filipa
Ferreira, Paulo Jorge Tavares
Louro, Henriqueta
Silva, Maria João
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ventura, Célia
Pinto, Fátima V.
Lourenço, Ana Filipa
Ferreira, Paulo Jorge Tavares
Louro, Henriqueta
Silva, Maria João
dc.subject.por.fl_str_mv Cellulose nanocrystals
Cellulose nanofibrils
Nanocellulose production
Genotoxicity
Immunotoxicity
Nanotoxicology
topic Cellulose nanocrystals
Cellulose nanofibrils
Nanocellulose production
Genotoxicity
Immunotoxicity
Nanotoxicology
description The need for reaching environmental sustainability encourages research on new cellulose-based materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a top-down approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-20
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/89368
http://hdl.handle.net/10316/89368
https://doi.org/10.1007/s10570-020-03176-9
url http://hdl.handle.net/10316/89368
https://doi.org/10.1007/s10570-020-03176-9
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0969-0239
1572-882X
https://link.springer.com/article/10.1007%2Fs10570-020-03176-9
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dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
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