Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure

Detalhes bibliográficos
Autor(a) principal: Vital, Nádia
Data de Publicação: 2022
Outros Autores: Ventura, Célia, Kranendonk, Michel, Silva, Maria João, Louro, Henriqueta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8299
Resumo: This article belongs to the Special Issue New Insights in Toxicity and Cytotoxicity of Nanomaterials
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spelling Toxicological Assessment of Cellulose Nanomaterials: Oral ExposureCellulose NanomaterialsEnvironmental GenotoxicityCellulose NanocrystalsCellulose NanofibresIngestionNanotoxicologyGenotoxicidade AmbientalThis article belongs to the Special Issue New Insights in Toxicity and Cytotoxicity of NanomaterialsReviewCellulose nanomaterials (CNMs) have emerged recently as an important group of sustainable bio-based nanomaterials (NMs) with potential applications in multiple sectors, including the food, food packaging, and biomedical fields. The widening of these applications leads to increased human oral exposure to these NMs and, potentially, to adverse health outcomes. Presently, the potential hazards regarding oral exposure to CNMs are insufficiently characterised. There is a need to understand and manage the potential adverse effects that might result from the ingestion of CNMs before products using CNMs reach commercialisation. This work reviews the potential applications of CNMs in the food and biomedical sectors along with the existing toxicological in vitro and in vivo studies, while also identifying current knowledge gaps. Relevant considerations when performing toxicological studies following oral exposure to CNMs are highlighted. An increasing number of studies have been published in the last years, overall showing that ingested CNMs are not toxic to the gastrointestinal tract (GIT), suggestive of the biocompatibility of the majority of the tested CNMs. However, in vitro and in vivo genotoxicity studies, as well as long-term carcinogenic or reproductive toxicity studies, are not yet available. These studies are needed to support a wider use of CNMs in applications that can lead to human oral ingestion, thereby promoting a safe and sustainable-by-design approach. View Full-TextThis work was funded by the Portuguese Fundação para a Ciência e a Tecnologia, I.P. (FCT), through national funds PTDC/SAU-PUB/32587/2017 and PTDC/SAU-PUB/29481/2017. Research was co-funded by UIDB/00009/2020; UIDP/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics, FCT— Fundação para a Ciência e a Tecnologia). N.V. work was funded by Fundação para a Ciência e a Tecnologia, I.P./Ministério da Ciência, Tecnologia, e Ensino Superior (FCT/MCTES) PhD grant 2020.07168.BDMDPIRepositório Científico do Instituto Nacional de SaúdeVital, NádiaVentura, CéliaKranendonk, MichelSilva, Maria JoãoLouro, Henriqueta2022-11-02T14:48:54Z2022-09-272022-09-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8299engNanomaterials (Basel). 2022 Sep 27;12(19):3375. doi: 10.3390/nano121933752079-499110.3390/nano12193375info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:30Zoai:repositorio.insa.pt:10400.18/8299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:58.713783Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
title Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
spellingShingle Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
Vital, Nádia
Cellulose Nanomaterials
Environmental Genotoxicity
Cellulose Nanocrystals
Cellulose Nanofibres
Ingestion
Nanotoxicology
Genotoxicidade Ambiental
title_short Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
title_full Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
title_fullStr Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
title_full_unstemmed Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
title_sort Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
author Vital, Nádia
author_facet Vital, Nádia
Ventura, Célia
Kranendonk, Michel
Silva, Maria João
Louro, Henriqueta
author_role author
author2 Ventura, Célia
Kranendonk, Michel
Silva, Maria João
Louro, Henriqueta
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Vital, Nádia
Ventura, Célia
Kranendonk, Michel
Silva, Maria João
Louro, Henriqueta
dc.subject.por.fl_str_mv Cellulose Nanomaterials
Environmental Genotoxicity
Cellulose Nanocrystals
Cellulose Nanofibres
Ingestion
Nanotoxicology
Genotoxicidade Ambiental
topic Cellulose Nanomaterials
Environmental Genotoxicity
Cellulose Nanocrystals
Cellulose Nanofibres
Ingestion
Nanotoxicology
Genotoxicidade Ambiental
description This article belongs to the Special Issue New Insights in Toxicity and Cytotoxicity of Nanomaterials
publishDate 2022
dc.date.none.fl_str_mv 2022-11-02T14:48:54Z
2022-09-27
2022-09-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8299
url http://hdl.handle.net/10400.18/8299
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanomaterials (Basel). 2022 Sep 27;12(19):3375. doi: 10.3390/nano12193375
2079-4991
10.3390/nano12193375
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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